Protein Alignment ZNF423 and cg

DIOPT Version :10

• Sequence 1: XP_047289759.1
• Gene: ZNF423 / 23090
• HGNCID: 16762
• Length: 1373
• Species: Homo sapiens
• Sequence 2: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 1091
• Identity: 209/1091 - (19%)
• Similarity: 348/1091 - (31%)
• Gaps: 406/1091 - (37%)

Human    12 GNKDSKSPL---PKVTQQATGGVYDQRGLAHPILTSADWSL-------------EGSEKRSHF-- 58
            ||:.::|.|   |.:.       |...|.:.|.|.|.|.||             :.:..|..|
  Fly    20 GNRAAESVLEISPNIN-------YTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVV 77

Human    59 -NP-YLPGELCLILRRAIGSISMNVVTCEEVAQCVLT------TVEEGEASDFSLAWDSSVTAAG 115
             :| :.||...:|   ..|..| .||..::..|.||:      .|:...|:       ::..|||
  Fly    78 NDPSFPPGTQRVI---TAGGAS-TVVKKQDNNQQVLSLDKNYLLVDPATAA-------AAAAAAG 131

Human   116 GLEGEPE---------CDQKTSRALEDRNSVT-------------SQEERNEDDEDMEDESIYTC 158
            |..|...         .|.||.:.:....|..             :|||.||    :..:.....
  Fly   132 GDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNE----ILIKRAIAA 192

Human   159 DHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGD---GCDL------ 214
            .|.|....:.||.:.|.|.               ..:||...|...|.::||   |..:
  Fly   193 GHHQTHTITAADGSHHHAS---------------GGTPSFCSVGGATTLLGDILPGISVQVQKVI 242

Human   215 -GLGEEEGGTG------------------------------------LPYPCQFCDKSFIRLSYL 242
             ||.:.|...|                                    .||.|..|.|||:...:|
  Fly   243 QGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHL 307

Human   243 KRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSS 307
            ..|.::|:.:.|..||:|.:.|.||...:.|:.||:.::.|.|.||:.:|:...||..|.:.||.
  Fly   308 TTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSR 372

Human   308 SKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVL 372
            .:||.|..|.|.|    .|:.|:..|         |:..|.:..::|:.|.::|:|
  Fly   373 ERPFVCQECGRAF----PLKRHLVTH---------SKFHAGERPYVCEECGESFAQ--------- 415

Human   373 TRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQP 437
                                   ||.|:.|                   |...|
  Fly   416 -----------------------ENHLIMH-------------------SRFHG----------- 427

Human   438 DSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPY 502
                 |::|
  Fly   428 -----SLNP-------------------------------------------------------- 431

Human   503 CSKRDFNSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNIS 567
                                       ..|..|..|.|..:.|..|.| :|          |.|
  Fly   432 ---------------------------FVCAECGASFPRKFQLVNHGR-IH----------GKI- 457

Human   568 AFHCNYCPEMFADINSLQEHIRVSHCGPNANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSV 632
            ...|..|.:.|....:|..|:|..|.|..|:|        |..|..||||::.|.:|::.||..|
  Fly   458 PHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHP--------CVSCGEGFLTKAELHQHVRTAHNGV 514

Human   633 GSAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSS 697
            .                     |..:::.|..            ::.:..||..::..:..|.:.
  Fly   515 N---------------------PNTSSATIIA------------NQQLQQAHHHQAGQQTHPQTI 546

Human   698 DVEVSSPKRQRL----SASANSISNGEYPCNQCDLKFSNFESFQTHLKLHL-ELLLRKQACPQCK 757
            .| ||:|....|    :..||.::..::.|.:|...|::.|:...||:||. :..|....|
  Fly   547 TV-VSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLC---- 606

Human   758 EDFDSQESLLQHLTVHYMTTST--HYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLC------ 814
                   :|...|..|:::|::  .....:.:........:...::.....|:...||.
  Fly   607 -------ALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANST 664

Human   815 --QEVFDSKVSIQVHLAVKH----SNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCI 873
              |.|..:..::.||...:|    :.:::..:        :::...|.||......|..|:|.|.
  Fly   665 HPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQ--------QQQQQQQQHVVSVAPANKPKSHFCA 721

Human   874 FCGETFSTEVELQCHITTHS------KKYNCKFCSKAF----HAIILLEKHLREKHCVF---DAA 925
            .||:.|:.:..|..|...|.      :.:.|: |.|||    |.::...:||..|..:.   :||
  Fly   722 SCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCE-CGKAFFQKNHLMLHQRQHLETKPAISQQQEAA 785

Human   926 TEN--GTANGVPPMATKKAEPADLQGMLLK----NPEAPNSHEASEDDVDA 970
            |:.  .||.....:..:......:.|.::|    ....|...:..:.|::|
  Fly   786 TQQQLATAGEQQQVQVQIMPDGQIHGKVIKYEICRNVMPEDQQQEQADMNA 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF423	XP_047289759.1	C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		COG5048	283..684	CDD:227381	66/400 (17%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..373	CDD:275368	4/18 (22%)
		C2H2 Zn finger	500..521	CDD:275368	0/20 (0%)
		C2H2 Zn finger	532..553	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..590	CDD:275368	5/18 (28%)
		C2H2 Zn finger	753..773	CDD:275368	3/19 (16%)
		C2H2 Zn finger	783..804	CDD:275368	0/20 (0%)
		C2H2 Zn finger	811..832	CDD:275368	6/28 (21%)
		C2H2 Zn finger	841..862	CDD:275368	3/20 (15%)
		C2H2 Zn finger	872..892	CDD:275368	6/19 (32%)
		C2H2 Zn finger	898..916	CDD:275368	7/21 (33%)
		C2H2 Zn finger	977..998	CDD:275368
		C2H2 Zn finger	1021..1041	CDD:275368
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1289..1309	CDD:275368
		C2H2 Zn finger	1320..1341	CDD:275368
		C2H2 Zn finger	1350..1366	CDD:275368
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	28/83 (34%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:463886	8/24 (33%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	8/32 (25%)
		C2H2 Zn finger	406..426	CDD:275368	9/70 (13%)
		C2H2 Zn finger	434..454	CDD:275368	7/20 (35%)
		C2H2 Zn finger	461..482	CDD:275368	6/20 (30%)
		C2H2 Zn finger	490..509	CDD:275368	8/18 (44%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	6/19 (32%)