DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF423 and shn

DIOPT Version :9

Sequence 1:	XP_006721234.1	Gene:	ZNF423 / 23090	HGNCID:	16762	Length:	1299	Species:	Homo sapiens
Sequence 2:	NP_001260883.1	Gene:	shn / 36171	FlyBaseID:	FBgn0003396	Length:	2587	Species:	Drosophila melanogaster

Alignment Length:	808	Identity:	157/808 - (19%)
Similarity:	258/808 - (31%)	Gaps:	243/808 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   205 GDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAK- 268
            |..:|.|.||.....:...||.|::||:..:||.|:.|...|.:..:|..|||    :|.|..|
  Fly  1812 GRGRYVCSECGIRCKKPSMLKKHIRTHTDVRPFTCSHCNFSFKTKGNLTKHMQ----SKTHFKKC 1872

Human   269 -------------SE------------------------KEAKKDDFMCDYCE--DTFSQTEELE 294
                         ||                        .|:..||:..:..|  ||.......:
  Fly  1873 IELGINPGPMPPDSEFLDVDMDFDQQSSTSAGGRTSSMAGESDSDDYSDNESESSDTDESKSRQK 1937

Human   295 KHVLTR-----------------HPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHA-----NQK 337
            :|...|                 :|||                 ::|.|.....|::     :|.
  Fly  1938 EHEAARGLLSLSMTPPIPQSVSPYPQL-----------------QDTPLPAASPANSIGSSGSQP 1985

Human   338 HK--C----PMCPEQFSSVEGVYCHLDSHRQPDS-SNHSVSPDPVLGSVASMSSATPDSSASVER 395
            .:  |    |..|..:...|..|.:.:..:...| :|...:|..:.....|:...:| |..||..
  Fly  1986 KRLVCSFTSPKPPFDYQKQEQYYSNPEESKPKRSVANEESAPMDLTKPRGSILLISP-SPVSVPA 2049

Human   396 GSTPDSTLKPLRGQKKMRD-------DGQGWTKVVYS----------CPYCSKRDFNSLAV-LEI 442
            ...|.|.      .::|.|       :..|:.|.:.|          ....:|.:.....| |:.
  Fly  2050 HDLPKSQ------AQQMHDVIFGTSGNESGFMKTLISVSDKVRISAEMEEQAKHEAEGEDVQLQT 2108

Human   443 HLK--TIHADKPQQSHTCQICLDSMPTLYNLNEHVRK----LHKNHAYPVMQFGNISAF--HCNY 499
            ::|  .:|..|.:||...:..|  :.|||.....|..    |...::.|||....:.:.  |...
  Fly  2109 YIKEHALHQAKIKQSQFSRSYL--INTLYTAASPVMSSSSTLFTANSRPVMSVNEVPSIEVHEVK 2171

Human   500 CPEMFADINSLQEHIRV--------SHCGPN-ANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAH 555
            .||......|..|...|        .:..|| |.|.:.|                 |...:||..
  Fly  2172 TPEAIESPRSAPEQAPVILAQIAQEENEEPNIAEPHNAN-----------------LPAAVQQPD 2219

Human   556 CSVGSAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSP 620
            .:..:..|.:|...||.| :...|....|.:|:                              :|
  Fly  2220 VNEFTGVLGNPTAPPTSS-VTATSVSTTTAAPV------------------------------AP 2253

Human   621 VSSDVEVSSPKRQRLSASANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKED 685
             ||....:.|.::.:....:...:........||:..::........:..:   .:..|..|.:.
  Fly  2254 -SSTANSTQPAQRTVIVGEDGFKSSTPTSKSGDLQHVSYGRGVPPAPIAGD---ARPTCTMCSKT 2314

Human   686 FDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSI 750
            |..|..|..|:.:|||  ...:.||.|...|.:...||||..             .|...:||.:
  Fly  2315 FQRQHQLTLHMNIHYM--ERKFKCEPCSISFRTQGHLQKHER-------------SEAHKNKVMM 2364

Human   751 QVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAH-KCIFCGE--TFSTEVELQ 812
            .....|..::..:.:.||.|...||....|..|::       :|.| :.:.|.:  .|.|..|::
  Fly  2365 TSTFGVPTTSNPRPFECTDCKIAFRIHGHLAKHLR-------SKTHVQKLECLQKLPFGTYAEIE 2422

Human   813 ------CHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAA--TENGTANGVPPMATKKAE 869
                  ..|.|..       |..:..::.||.:.|:||    |..  :...|.:|:..:|...|.
  Fly  2423 RAGISLTEIDTSD-------CENSLISLKLLAQKLQEK----DPGKLSSYTTPSGMMQLAQDAAG 2476

Human   870 PADLQGMLLKNPEAPNSHEASEDDVDAS 897
            |.             :...||||...|:
  Fly  2477 PV-------------SQDSASEDGFSAA 2491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF423	XP_006721234.1	C2H2 Zn finger	155..175	CDD:275368
		C2H2 Zn finger	183..203	CDD:275368
		COG5048	209..610	CDD:227381	97/504 (19%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	239..259	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..299	CDD:275368	4/20 (20%)
		C2H2 Zn finger	426..447	CDD:275368	4/23 (17%)
		C2H2 Zn finger	458..479	CDD:275368	5/24 (21%)
		C2H2 Zn finger	497..516	CDD:275368	4/18 (22%)
		C2H2 Zn finger	679..699	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..730	CDD:275368	8/20 (40%)
		C2H2 Zn finger	737..758	CDD:275368	4/20 (20%)
		C2H2 Zn finger	767..788	CDD:275368	7/20 (35%)
		C2H2 Zn finger	798..818	CDD:275368	5/27 (19%)
		C2H2 Zn finger	824..842	CDD:275368	3/17 (18%)
		C2H2 Zn finger	903..924	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1215..1235	CDD:275368
		C2H2 Zn finger	1246..1267	CDD:275368
		C2H2 Zn finger	1276..1292	CDD:275368
shn	NP_001260883.1	C2H2 Zn finger	486..506	CDD:275368
		zf-H2C2_2	499..523	CDD:290200
		C2H2 Zn finger	514..536	CDD:275368
		zf-C2H2	1816..1838	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1818..1838	CDD:275370	6/19 (32%)
		zf-H2C2_2	1830..1855	CDD:290200	10/24 (42%)
		zf-C2H2	1844..1868	CDD:278523	9/27 (33%)
		C2H2 Zn finger	1846..1868	CDD:275370	8/25 (32%)
		zf-C2H2	2307..2328	CDD:278523	6/20 (30%)
		C2H2 Zn finger	2308..2328	CDD:275368	6/19 (32%)
		zf-C2H2_jaz	2333..2359	CDD:288983	9/38 (24%)
		C2H2 Zn finger	2336..2358	CDD:275368	9/34 (26%)
		C2H2 Zn finger	2381..2403	CDD:275368	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000