DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF423 and CG30020

DIOPT Version :10

Sequence 1:XP_047289759.1 Gene:ZNF423 / 23090 HGNCID:16762 Length:1373 Species:Homo sapiens
Sequence 2:NP_610627.2 Gene:CG30020 / 36156 FlyBaseID:FBgn0050020 Length:1309 Species:Drosophila melanogaster


Alignment Length:1461 Identity:263/1461 - (18%)
Similarity:448/1461 - (30%) Gaps:564/1461 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   198 SKDVASPTQMIG-DGCDLGLGEEEGGTGLP-YPCQFCDKSFIRLSY------LKRHEQIHSDKLP 254
            |.|.|..|:.|. ..|.|.....:....|| :.|..|.|| ::::|      |:.||.:      
  Fly    46 SLDPADATEKIPLLRCLLFCVSADNAPELPQHICLECSKS-LQVAYYFLQNALRAHEIL------ 103

Human   255 FKCTYCSRLFKHKRSRDRHIKLHTGDKKYHC-----------HECEAA----FSRSDHLKIHLKT 304
                 |.:|.. |.|:..:..|....:|..|           |||:..    ::|.: ||.|::.
  Fly   104 -----CRKLCP-KVSKRLNGTLAQEQEKPACAEPVQPLKTMRHECQVCGVVLYNRLE-LKQHIRQ 161

Human   305 HSSSKPFKCTVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEK 369
            |:....:.|.:|    |.||..|..:..|.....::                   ..||.||   
  Fly   162 HAEGLSYNCKLC----SFTSLKQRTLFEHYVTMHNM-------------------PLSQAEE--- 200

Human   370 HVLTRHPQLSEKADLQCIHCPEVFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSH 434
            :|.::|....::.:::.:...|   |...|:..:            :.||.:..   .:.|:|:.
  Fly   201 YVKSKHLPAPKEEEVKAVCTLE---DMELLIPTV------------LRPEDYVQ---PHPHIDND 247

Human   435 RQPDSSNH-SVSPDPVLGSVASMSSA-----TPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGW 493
            :..|..:. :||.|..:.||.|::|.     ||:.|...|....||.:|:.:.|           
  Fly   248 QLRDIDHQLAVSMDEPVPSVDSLTSTLPPMDTPNVSIGTEYLVLPDGSLQQVNG----------- 301

Human   494 TKVVYSCPYCSKRDFNSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYN--LNEHVRKLHKNH 556
                            |..|:|.    |...||..|....:.|.::.:.:|  ::..|.:|....
  Fly   302 ----------------SGVVIEY----IDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEE 346

Human   557 AYPVMQF--------GNISAFHCNYCPEMFADINSLQEHIRVSHCG-PNANPSDGNNAFFCNQCS 612
            ..|.::.        .:|....|.:||:.|:.:..|:.| :::|.. |.         |||:||.
  Fly   347 MMPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSH-QLTHSNLPK---------FFCDQCD 401

Human   613 MGFLTESSLTEHIQQAHCSVG-SAKLESPVVQPTQSFMEVYSCPYCTNSPIF--GSILKLTKHIK 674
            ...|..:.|.:|.:..|..|. :.|......|..:|  .||||..|    :|  .::.:|..|.|
  Fly   402 FYSLRSADLIQHYKMVHHRVDENGKTGKEQAQGIES--RVYSCDMC----LFETSTVSQLRTHYK 460

Human   675 E------------------------------------NHKNIPLA--HSKKSKAEQSPVSSDV-- 699
            |                                    ||.:|||.  :.......|:|:...|  
  Fly   461 ERHTVQPTEVQLRPSWTGEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVH 525

Human   700 -EVSSPKRQR--------------------------LSASANS---------------------- 715
             .:..|.:|.                          .:|::||                      
  Fly   526 QPMPDPMQQTEPMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNH 590

Human   716 -------ISNGEYPCNQC-------------------------------------------DLKF 730
                   ||.|..|.|:.                                           |:..
  Fly   591 AFGIFPEISEGNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVI 655

Human   731 SN------------FESFQ----------------------THLKLHLELLLRKQACPQCKEDFD 761
            .|            ||.|:                      ........|||...  ....:|||
  Fly   656 DNNNISLDFDAENLFEDFEEEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSD--DDDVDDFD 718

Human   762 SQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSKVSIQV 826
            .::|  :||...|        |..|:|:|:|....:.|:........|.|.||..:::.|..:..
  Fly   719 DEQS--KHLQKPY--------CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIK 773

Human   827 H--------------------LAVKHSNEKKMY---------RCTACNWDFRKEADLQVHVK-HS 861
            |                    ::|..:|.:|:|         .|..|.::...:::::.|:. |.
  Fly   774 HYKTVHKRMPTRDMVQAKGDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHH 838

Human   862 HLGNPAKAHKCIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAAT 926
            .:.:....|    ..|.|          ......:.|..|.::|.|...|.:||:..|.| |...
  Fly   839 GINDGVSEH----ANEVF----------IIRKLPFECPRCIRSFAAKTTLSRHLQRSHLV-DTII 888

Human   927 ENGTANGVPPMATKKAEPADLQGMLLKNPEAPNSH-EASEDDVDASEPMYGCDICGAAYTMEVLL 990
            |..|.:....:.|..|..:......:.:......| |..:.||.|.:             |...|
  Fly   889 EMQTPHCGEAITTTMATSSSTISEPVNSVTVDGQHNEMMQTDVGAEK-------------MTEAL 940

Human   991 QNHRLRDHNIRPGEDDGSRKKAE-------------------------------------FIKGS 1018
            .|   .|.|...|.|||:..|||                                     .::..
  Fly   941 GN---GDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAIAAAISAAAAATATSLESP 1002

Human  1019 HKCNVCSRTF---------FSENGLREHLQTHRGPAKHYM-----------CPICGERFPSLLTL 1063
            ......|.|.         |..:.:|:..| ...|..|.:           ||| .|.: .||:.
  Fly  1003 VATTASSSTTLFPTPTPFDFDYDIMRDEAQ-QSSPNIHDVSKALSDNASSSCPI-NESY-KLLST 1064

Human  1064 TEHKVTHSKSLDTGT---------CRICKMPLQSEEEFIEH-CQMHPDLRNSLTGFRCVVCMQTV 1118
            |..:.:.:|.|.:.:         |::|........:.::| .::|.:...|..|::        
  Fly  1065 TALETSPAKGLRSNSRLHRSSIHICKLCNQTFDELGKLVKHEMELHSNTERSRWGYQ-------- 1121

Human  1119 TSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLVKLDVNGLPYGLCAG 1183
                                              :|||:|...:|: ..|:|..           
  Fly  1122 ----------------------------------HKCAICNTSYRT-LTLLKFH----------- 1140

Human  1184 CMARSANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESHMQVDHRDLTPETSGPRKGTQT 1248
             |.|.:|.:                .:|..|...|.:..:||.|.:..|                
  Fly  1141 -MKRHSNRK----------------SQCKLCPKSFVTIAELERHTKAKH---------------- 1172

Human  1249 SPVPRKKTYQCIK--CQMTFENEREIQIH-VANHMIEEGINHECKLCNQMFDSPAKLLCHLIEHS 1310
               .:.||.:|..  |:.||..:..:..| .|:|:   ...:.|.:||:...|...|..|:..|.
  Fly  1173 ---SKDKTLRCFMDGCRKTFAFKHHLIRHQKASHL---STRYICPVCNKEEKSNVHLKNHMSVHK 1231

Human  1311 FEGMGGTFKCPVCFTVFVQANKLQQHIFAVH 1341
            .|   .|:|||.|...:::..:|..|...:|
  Fly  1232 GE---ITYKCPKCDRSYLRRGRLVTHALIIH 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF423XP_047289759.1 C2H2 Zn finger 229..249 CDD:275368 8/25 (32%)
C2H2 Zn finger 257..277 CDD:275368 4/19 (21%)
COG5048 283..684 CDD:227381 94/473 (20%)
C2H2 Zn finger 285..305 CDD:275368 8/34 (24%)
C2H2 Zn finger 313..333 CDD:275368 6/19 (32%)
C2H2 Zn finger 354..373 CDD:275368 5/18 (28%)
C2H2 Zn finger 500..521 CDD:275368 3/20 (15%)
C2H2 Zn finger 532..553 CDD:275368 3/22 (14%)
C2H2 Zn finger 571..590 CDD:275368 6/18 (33%)
C2H2 Zn finger 753..773 CDD:275368 6/19 (32%)
C2H2 Zn finger 783..804 CDD:275368 6/20 (30%)
C2H2 Zn finger 811..832 CDD:275368 6/40 (15%)
C2H2 Zn finger 841..862 CDD:275368 4/21 (19%)
C2H2 Zn finger 872..892 CDD:275368 2/19 (11%)
C2H2 Zn finger 898..916 CDD:275368 6/17 (35%)
C2H2 Zn finger 977..998 CDD:275368 3/20 (15%)
C2H2 Zn finger 1021..1041 CDD:275368 5/28 (18%)
C2H2 Zn finger 1050..1070 CDD:275368 7/19 (37%)
C2H2 Zn finger 1289..1309 CDD:275368 6/19 (32%)
C2H2 Zn finger 1320..1341 CDD:275368 5/20 (25%)
C2H2 Zn finger 1350..1366 CDD:275368
CG30020NP_610627.2 zf-AD 25..103 CDD:214871 17/57 (30%)
C2H2 Zn finger 369..389 CDD:275368 6/20 (30%)
C2H2 Zn finger 397..418 CDD:275368 6/20 (30%)
C2H2 Zn finger 442..460 CDD:275368 5/21 (24%)
C2H2 Zn finger 730..750 CDD:275368 6/19 (32%)
C2H2 Zn finger 758..777 CDD:275368 5/18 (28%)
C2H2 Zn finger 1089..1110 CDD:275368 3/20 (15%)
C2H2 Zn finger 1124..1144 CDD:275368 7/32 (22%)
C2H2 Zn finger 1151..1172 CDD:275368 6/20 (30%)
C2H2 Zn finger 1180..1203 CDD:275368 6/22 (27%)
C2H2 Zn finger 1210..1230 CDD:275368 6/19 (32%)
C2H2 Zn finger 1238..1254 CDD:275368 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

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