Protein Alignment FOXO3 and FKH2

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_014331.3
• Gene: FKH2 / 855656
• SGDID: S000005012
• Length: 862
• Species: Saccharomyces cerevisiae
• Alignment Length: 656
• Identity: 149/656 - (22%)
• Similarity: 249/656 - (37%)
• Gaps: 137/656 - (20%)

Human    81 GGGGSGTLGSGLLLEDSARVL--------APGGQDPGSGPATAAGGLSGGTQALLQPQ--QPLPP 135
            |.||:...|||..|..|.:.:        ...|......|...|...:..|   :.||  .|..|
Yeast   241 GSGGNAPFGSGANLGPSEQGIFNNNNNSKNKNGYFTSINPNYTASTTTSNT---INPQAASPQGP 302

Human   136 PQPGAAGGSGQPRKCSS----------------RRNAWGNLSYADLITRAIESSPDKRLTLSQIY 184
            |....|.......|.|:                .||.....|||.:||:||.|||:..::|:.||
Yeast   303 PNTIIAANFVDSYKSSNAYPQALDFTSDLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIY 367

Human   185 EWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV---QNEGTGKSSWWIINPDGGKSGKA 246
            :::.....|::     .:.:||:|||||||||:..|.:|   .|| .||...|.|:       ::
Yeast   368 KYISSNYAYYR-----FAKSGWQNSIRHNLSLNKAFEKVPRRPNE-PGKGMKWRIS-------ES 419

Human   247 PRRRAVSMDNSNKYTK-SRGRAAKKKAALQTA-----PESADDSPSQLSKWPGSPTSRSSDELDA 305
            .::..::..|:.|..| .||.:..::..|..|     |...|...|.....|.....:|.:.|:.
Yeast   420 YQQEFLNKWNTGKVGKIRRGSSVARQLQLHMAKFNSLPMEMDYRLSLNMAQPPKRQLQSHNVLEP 484

Human   306 WTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLS-----------------PMLYSSSAS 353
                     ||.:.:.|.:..:.:...|...|....|:|                 ...::.:.:
Yeast   485 ---------SNNNIIEGFVQHVPSKGNLPASQQSQPPVSHQNQSQQPPPQEQRQEIQFTFADTQN 540

Human   354 LSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPP-------SQPSPTGGLMQRS 411
            .:.::::|  ::.|:|.    ..|.|..|.:|.|.:..:::. ||       ::.||...|:
Yeast   541 RNIALARP--IKTPQLQ----APNSNANLNQNNMKEYKESLH-PPAISISQMNRQSPNNALV--- 595

Human   412 SSFPYTTKGSGL-----GSPTSSFNSTVFGPSSLNSLRQSPMQTIQEN---KPATFSSMSHYGNQ 468
             ||......|.:     .|...|.|:.  |.:.:| |......::.||   :|.|.:| |...|.
Yeast   596 -SFTNACANSKIINNISDSADKSTNNN--GGTKMN-LPAISTSSLDENGNLEPTTTTS-SGNSNS 655

Human   469 TLQDLLTSDSLSHSDVMMTQS-DPLMSQAS-----TAVSAQNSRRNVMLR-NDPMMSFAAQPNQG 526
            ..|...|:.||:.:.:.::|. |.|:...:     ||:.|....|....| ..|:.|.:...|..
Yeast   656 VPQTGTTTSSLAANSLRLSQPYDTLLRSPTKAFHITAMEAYTPERGSANRARSPLHSNSNNTNNN 720

Human   527 SLVNQNLLHHQHQTQGALGGSRAL---SNSVSNMGLSESS-----SLGSAKHQQQSP-------- 575
            ...|.||     ||.|.......|   ||.:.:|..:..:     |...:::.:.||
Yeast   721 GANNSNL-----QTSGMENKQTGLVLDSNVLKSMESNNDNRRLTPSTSKSQNVKSSPGVWNLLQF 780

Human   576 VSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDF 640
            .|.:....:||......:|.:.::....:|...|:.|.|..:..||  .:.|..|.|.:..|...
Yeast   781 SSTNNTPAADSGGNKRGFSINPDIKAKENENATSEKDSDSNSNDLE--TKDINSSPLKNQGGSTA 843

Human   641 NFDSLI 646
            |...||
Yeast   844 NAKELI 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		20/97 (21%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108		9/34 (26%)
		FH_FOXO3	157..239	CDD:410835	33/84 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		14/76 (18%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		1/16 (6%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		82/402 (20%)
		FOXO_KIX_bdg	432..511	CDD:465228	21/87 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587		12/66 (18%)
		FOXO-TAD	606..644	CDD:435506	10/37 (27%)
FKH2	NP_014331.3	COG5025	1..610	CDD:227358	91/404 (23%)