DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and FKH1

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_012135.1 Gene:FKH1 / 854675 SGDID:S000001393 Length:484 Species:Saccharomyces cerevisiae


Alignment Length:316 Identity:67/316 - (21%)
Similarity:119/316 - (37%) Gaps:92/316 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    35 LQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSAR 99
            |..|...:|...|.|:...|:::.||::::::...||                            
Yeast   230 LHTPLSSSSDVNPIGDPHGDTIMMEEDEEDENYTRGG---------------------------- 266

Human   100 VLAPGGQDPGSGPATAAGG---LSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLS 161
             :.|......|..|...|.   :...:...|...:.:.|||                       |
Yeast   267 -IRPNTYTSSSNNAVTNGNVPHIENPSDLSLDENRYIKPPQ-----------------------S 307

Human   162 YADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNE 226
            ||.:||:||.|:|:..::|:.||:::.....:::     .|...|:||:||||||:..|.:|...
Yeast   308 YASMITQAILSTPEGSISLADIYKFISDNYAFYR-----FSQMAWQNSVRHNLSLNKAFEKVPKR 367

Human   227 G--TGKSSWWIINPD----------GGKSGKAPRRRAVSMD---NSNKYTK----------SRG- 265
            .  .||...|.|:.:          .||..|..|..:|:..   :.:|:.:          .|| 
Yeast   368 AGQQGKGMNWKISDEVRRDFLNKWNAGKLSKIRRGASVTRQLQLHMSKFGEIPAPESSSIDPRGI 432

Human   266 RAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVS 321
            :|.|.|.:||.......:|..||.:      ::.:.::...|.....||:|.:..|
Yeast   433 KAQKVKKSLQATSSILGESAPQLQR------TQLTGQISTTTSMDVTTNANVNNSS 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 18/120 (15%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 1/27 (4%)
FH_FOXO3 157..239 CDD:410835 28/83 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 18/94 (19%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 4/19 (21%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 5/22 (23%)
FOXO_KIX_bdg 432..511 CDD:465228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
FKH1NP_012135.1 COG5025 1..484 CDD:227358 67/316 (21%)
Blue background indicates that the domain is not in the aligned region.

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