DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and HCM1

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_009991.2 Gene:HCM1 / 850429 SGDID:S000000661 Length:564 Species:Saccharomyces cerevisiae


Alignment Length:482 Identity:119/482 - (24%)
Similarity:171/482 - (35%) Gaps:147/482 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    94 LEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCS---SRRN 155
            |||...::.|    |.|   |....:.   :...:|..||.|........|...|:.|   :|.|
Yeast    31 LEDEKEMITP----PSS---TVRKTMK---EVNKRPSHPLSPDHSSPIAPSKAKRQRSDTCARSN 85

Human   156 AWGNL------------------------SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKD 196
              |||                        |||.||..||..|.:.:|||||||.|:....||:|.
Yeast    86 --GNLTLEEILQSLERRRINGELAKKPPYSYATLICLAILQSQEGKLTLSQIYHWIHVHFPYYKQ 148

Human   197 KGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYT 261
            |     .|.|:|||||||||:..|::.:....||..:|.:.|..                ..|:.
Yeast   149 K-----DASWQNSIRHNLSLNDAFIKTEKSCDGKGHFWEVRPGA----------------ETKFF 192

Human   262 KSRGRAAK-KKAALQTAP-----ESADDSPSQLSKWPGS---PTSRSSDELDAWTDFRSRTNSNA 317
            |...|..: .|.:||...     :|..|...|:....|:   |.....:|...:.....:.||  
Yeast   193 KGENRGYEFVKDSLQDIGKYFEIDSTLDELEQVESGEGNDDLPDEEEREEAGKFPSIEIQLNS-- 255

Human   318 STVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSP-------------------SVSKPCT 363
                   |||:..::|..:        |.|.:.::.|:|                   |:..|..
Yeast   256 -------SPILRVSQLHHI--------PQLKTDNSVLNPHENLESMRNMIENDVNNIDSLEPPYV 305

Human   364 VE-------LPRLTD-----MAGTMNLNDGLTE-NLMDDLLDNITLP-PSQPSPTGGLMQRSSSF 414
            ::       ||.|.:     .||..|.|  :|: |..:      ||| .|..||        .:|
Yeast   306 MKKYHTSLGLPSLVNAKDHFQAGVKNNN--ITQANRFN------TLPITSAKSP--------QNF 354

Human   415 -PYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFS---SMSHYGNQTL----- 470
             .|.|..:......|...|.|...|.|:.|..||::...:...|..|   |...|.|..|     
Yeast   355 RKYFTSFNSNFEDLSPLRSNVGAGSLLDPLPYSPLKLYDQKNLALMSKPQSQQSYSNSQLPPPPS 419

Human   471 ---QDLLTSDSLSHSDVMMTQSDPLMS 494
               .|||.:..:.|||.:......|:|
Yeast   420 SHGSDLLKTPKMRHSDGLEKTPSRLIS 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 14/61 (23%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 4/13 (31%)
FH_FOXO3 157..239 CDD:410835 38/105 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 13/79 (16%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 0/16 (0%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 53/240 (22%)
FOXO_KIX_bdg 432..511 CDD:465228 21/74 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
HCM1NP_009991.2 COG5025 20..564 CDD:227358 119/482 (25%)
Blue background indicates that the domain is not in the aligned region.

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