Protein Alignment FOXO3 and Foxo3

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_062714.1
• Gene: Foxo3 / 56484
• MGIID: 1890081
• Length: 672
• Species: Mus musculus
• Alignment Length: 673
• Identity: 637/673 - (94%)
• Similarity: 647/673 - (96%)
• Gaps: 1/673 - (0%)

Human     1 MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDED 65
            ||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse     1 MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDED 65

Human    66 DEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQ 130
            ||||||||.|||.| |||.|.||||||||||||.:|||||||.|||||:|||.|||||...||||
Mouse    66 DEDGGGRASSAMVI-GGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSGGTPTQLQPQ 129

Human   131 QPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFK 195
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   130 QPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFK 194

Human   196 DKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKY 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 DKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKY 259

Human   261 TKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLS 325
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 TKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLS 324

Human   326 PIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDL 390
            ||:||||||:|||||.|||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse   325 PILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDL 389

Human   391 LDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENK 455
            ||||.||||||||.||||||.||||||.|.|||||||.||||||||||||||||||||||||||:
Mouse   390 LDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENR 454

Human   456 PATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFA 520
            ||||||:||||||||||||.|||||||||||||||||||||||||||||:|||||||||||||||
Mouse   455 PATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFA 519

Human   521 AQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSD 585
            |||.||||||||||||||||||||||||||||||||||||:||||||||||||||.|||||||||
Mouse   520 AQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPASQSMQTLSD 584

Human   586 SLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQN 650
            |||||||||.|||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   585 SLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQN 649

Human   651 VVGLNVGNFTGAKQASSQSWVPG 673
            |||||||||||||||||||||||
Mouse   650 VVGLNVGNFTGAKQASSQSWVPG 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		135/151 (89%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108		22/27 (81%)
		FH_FOXO3	157..239	CDD:410835	81/81 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		69/70 (99%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		16/16 (100%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		353/372 (95%)
		FOXO_KIX_bdg	432..511	CDD:465228	74/78 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587		48/50 (96%)
		FOXO-TAD	606..644	CDD:435506	37/37 (100%)
Foxo3	NP_062714.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..85		78/84 (93%)
		Required for mitochondrial import. /evidence=ECO:0000250|UniProtKB:O43524	80..108		23/27 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..152		35/41 (85%)
		FH_FOXO3	156..238	CDD:410835	81/81 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..301		69/70 (99%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43524	241..258		16/16 (100%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000250|UniProtKB:O43524	299..672		353/372 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..441		36/41 (88%)
		FOXO_KIX_bdg	431..510	CDD:465228	74/78 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..583		45/47 (96%)
		FOXO-TAD	605..643	CDD:435506	37/37 (100%)