DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and fd102C

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_651951.1 Gene:fd102C / 43843 FlyBaseID:FBgn0039937 Length:599 Species:Drosophila melanogaster


Alignment Length:569 Identity:129/569 - (22%)
Similarity:211/569 - (37%) Gaps:149/569 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    80 GGGGGSGTLGSGLLLEDSARVLAPGGQDPGSG--------PATAAGGLSGGTQALLQPQQPLPPP 136
            ||.||||.....|       .|:|.|.. |||        .|.:...|...||.:.||::|.|  
  Fly    76 GGTGGSGASAPWL-------HLSPYGHH-GSGSLPSVNRMAALSTISLFPQTQRIFQPEEPKP-- 130

Human   137 QPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSN 201
                                  ..||..||..||.||.|.:|.||.||::::...|||:.:|   
  Fly   131 ----------------------QHSYIGLIAMAILSSTDMKLVLSDIYQYILDNYPYFRSRG--- 170

Human   202 SSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINP---DGGKSGKAPRRRAVSMDNSNKYTKS 263
              .||:|||||||||:..|::......||..:|.|:|   :..:.|...||:|            
  Fly   171 --PGWRNSIRHNLSLNDCFIKSGRSANGKGHYWAIHPANMEDFRKGDFRRRKA------------ 221

Human   264 RGRAAKKKAALQTAPESADDSPS----QLSKWPGSPTSRSSDELDAW---------TDFRSRTNS 315
             .|..:|...| :..:::.||||    .|:. |..|:|:|:.:|.|.         ..|.:|:::
  Fly   222 -QRKVRKHMGL-SVDDASTDSPSPPPLDLTT-PPPPSSQSALQLSALGYPYHQHYIGQFFNRSSA 283

Human   316 NASTVSGRLSPIMASTELDEVQDDDAPLSP------------MLYSSSASLSPSVSKPCTVELPR 368
            ...|......|.:. .:..|..:.|..:.|            ..|.:|.: :.:::...:....|
  Fly   284 PGMTHYSPPDPALL-MQRQEANNLDQTIQPTQLQQPHSHHQHFAYINSTT-TTTIANMFSQTRKR 346

Human   369 LTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNST 433
            ..|:|..:..:..:.:.:.:|                   |.||..|.|:     ...|:..:.|
  Fly   347 QFDVASLLAPDVQIVDIVSED-------------------QESSVTPTTS-----ARTTTQTHHT 387

Human   434 VFGPSSLNSLRQSPMQTIQE------NKPATFSSMS-----HYGNQTLQDLLTSDSLSHSDVMMT 487
            |.           ..|||..      .||...:.:.     ......:.|.:..|:.|::|    
  Fly   388 VI-----------TKQTIHREVVLGLEKPVQDADIDADIDVEVNVDVVDDSIIPDTDSYTD---- 437

Human   488 QSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSN 552
            ..|...::.:..........|..|.:..:.||.|.|:.....:...| .||....|...:|:|.:
  Fly   438 GEDRKKTRGTLKQIFSIEDNNSYLIDGRLSSFDADPDHDPDHDPEDL-EQHNFSIASSAARSLGS 501

Human   553 SVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPV 601
            |.|..  .|||||      ::.|:.:.:.....:|..|...:.::.|.|
  Fly   502 SSSQH--EESSSL------EECPIQECIVAPQTALISSMATAKTSTLSV 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 21/80 (26%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 10/27 (37%)
FH_FOXO3 157..239 CDD:410835 35/84 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 19/77 (25%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 4/16 (25%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 57/334 (17%)
FOXO_KIX_bdg 432..511 CDD:465228 13/89 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 13/50 (26%)
FOXO-TAD 606..644 CDD:435506
fd102CNP_651951.1 FH_FOXQ2-like 129..223 CDD:410809 40/135 (30%)
Blue background indicates that the domain is not in the aligned region.

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