DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and fkh

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_001263038.1 Gene:fkh / 43383 FlyBaseID:FBgn0000659 Length:692 Species:Drosophila melanogaster


Alignment Length:597 Identity:130/597 - (21%)
Similarity:209/597 - (35%) Gaps:154/597 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    71 GRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPG----SGPATAAGGLSGGTQALLQPQQ 131
            |..|:| |:...||:....|.:   ..|.:.:|.|...|    |..:.:|.||||...|:....:
  Fly   121 GSMGAA-AMNSMGGNCMTPSSM---SYASMGSPLGNMGGCMAMSAASMSAAGLSGTYGAMPPGSR 181

Human   132 PLPPPQPGAAGGSGQPRKCSSRR---NAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPY 193
            .:....|.:.|.|...:..:.||   :|....||..|||.||:::|.:.||||:||::::...|:
  Fly   182 EMETGSPNSLGRSRVDKPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPF 246

Human   194 FKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINPDGGKSGKAPRRRAVSMDN 256
            ::     .:...|:|||||:||.:..|:::..  :..||.|:|.::||.|           :|..
  Fly   247 YR-----QNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSG-----------NMFE 295

Human   257 SNKYTKSRGR-AAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTV 320
            :..|.:.:.| ..:||.|::...:|...|..:.:. ||......|..:......|...:.:....
  Fly   296 NGCYLRRQKRFKDEKKEAIRQLHKSPSHSSLEATS-PGKKDHEDSHHMHHHHHSRLDHHQHHKEA 359

Human   321 SGRLSPIMASTELDEVQDDDAPLSPMLYSSS------------------------ASLSPSVSKP 361
            .|  :.|.....|......||....||::::                        ..||..::..
  Fly   360 GG--ASIAGVNVLSAAHSKDAEALAMLHANAELCLSQQPQHVPTHHHHQHHQLQQEELSAMMANR 422

Human   362 CTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSP 426
            |...|  :||...:|:                    |.:..|:|          ||        |
  Fly   423 CHPSL--ITDYHSSMH--------------------PLKQEPSG----------YT--------P 447

Human   427 TSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDP 491
            :|.       |.|:|  |..|.::..:.|   ...||.|........||:...:.......||..
  Fly   448 SSH-------PFSIN--RLLPTESKADIK---MYDMSQYAGYNALSPLTNSHAALGQDSYYQSLG 500

Human   492 LMSQASTAVSAQN------SRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQ--------- 541
            ..:.|.|.....:      .|...|||:........|..|.....|....||.|.|         
  Fly   501 YHAPAGTTSLXHHQYPLAXGRAEQMLRSQQQQHLQQQHQQHQQQQQQHQLHQQQQQMQQSAQQLT 565

Human   542 --------GALGGSRALSNSVSNMGLSESSSLGS----------------------AKHQQQSPV 576
                    .|....:|.|.|.|..|....|..||                      ..||||..:
  Fly   566 SASNTPATSAKASGKAGSASASGSGSGSGSGSGSNYSQKLQQQHQQQQQQQAAAQQQHHQQQQQL 630

Human   577 SQSMQTLSDSLS 588
            .|.:|..|.:::
  Fly   631 LQELQEDSSNIT 642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 21/85 (25%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 6/27 (22%)
FH_FOXO3 157..239 CDD:410835 28/83 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 16/71 (23%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 1/16 (6%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 65/358 (18%)
FOXO_KIX_bdg 432..511 CDD:465228 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 20/89 (22%)
FOXO-TAD 606..644 CDD:435506
fkhNP_001263038.1 Forkhead_N <120..209 CDD:369872 23/91 (25%)
FH_dFKH 210..307 CDD:410815 34/112 (30%)
Blue background indicates that the domain is not in the aligned region.

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