DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FOXO3 and foxo

DIOPT Version :9

Sequence 1:	NP_001446.1	Gene:	FOXO3 / 2309	HGNCID:	3821	Length:	673	Species:	Homo sapiens
Sequence 2:	NP_001262557.1	Gene:	foxo / 41709	FlyBaseID:	FBgn0038197	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	230/701 - (32%)
Similarity:	286/701 - (40%)	Gaps:	236/701 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    15 EVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAI 79
            ::.||..||||:|.||.|||..|||....|......|.|
  Fly    27 DLPLDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKA-------------------------- 65

Human    80 GGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGS 144
                             |.:.||||........|.||
  Fly    66 -----------------SNQQLAPGDSQQAIQNANAA---------------------------- 85

Human   145 GQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNS 209
               :|.|||||||||||||||||.||.|:.||||||||||||||:.|||||||||||||||||||
  Fly    86 ---KKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNS 147

Human   210 IRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAAL 274
            ||||||||:||||||||||||||||::||: .|.||:.||||.||:.| :|.|.||||.|:..||
  Fly   148 IRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMETS-RYEKRRGRAKKRVEAL 210

Human   275 QTAP----ESADDSPSQ-----LSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS 330
            :.|.    ..|..|||.     |..:|.||. .|........|||.|.:||||: .||||||.|
  Fly   211 RQAGVVGLNDATPSPSSSVSEGLDHFPESPL-HSGGGFQLSPDFRQRASSNASS-CGRLSPIRA- 272

Human   331 TELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNIT 395
                  ||               |.|....|...:...:| .|....|     |.|...:.|.:|
  Fly   273 ------QD---------------LEPDWGFPVDYQNTTMT-QAHAQAL-----EELTGTMADELT 310

Human   396 L-------------PPSQPSP--------TGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSS 439
            |             .||||.|        .....|:....||...|     |.|.:|:  ..|.|
  Fly   311 LCNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYALNG-----PASGYNT--LQPQS 368

Human   440 LNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQN 504
            ...|.:|...:...|                    ..|.||.:.|..|.|.          :..|
  Fly   369 QCLLHRSLNCSCMHN--------------------ARDGLSPNSVTTTMSP----------AYPN 403

Human   505 SRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNM---GLSESSSLG 566
            |                :|:..||                       |:.||:   |.:::::|.
  Fly   404 S----------------EPSSDSL-----------------------NTYSNVVLDGPADTAALM 429

Human   567 SAKHQQQSPVSQSMQTLSDSLSGSSLYSTSAN--LPVMGHEKFPSDLDLDMFN------GSLECD 623
            ..:.|||    |..|.||.||..::..||...  |.|:.:|..|    :|.||      |:|||:
  Fly   430 VQQQQQQ----QQQQQLSASLEDNNCASTLIGQCLEVLNNEAQP----IDEFNLENFPVGNLECN 486

Human   624 MESIIRSELMDADGLDFNFDSLISTQNVVG-----LNVGNFTGAKQASSQS 669
            :|.:::.|:.....||.|........|:|.     |::.|.:.....||.|
  Fly   487 VEELLQQEMSYGGLLDINIPLATVNTNLVNSSSGPLSISNISNLSNISSNS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..153		28/137 (20%)
		Required for mitochondrial import. /evidence=ECO:0000269\|PubMed:23283301	80..108		5/27 (19%)
		FH	157..237	CDD:238016	71/79 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..302		35/79 (44%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:17940099, ECO:0000269\|PubMed:29445193	242..259		10/16 (63%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269\|PubMed:15084260	300..673		95/407 (23%)
		FOXO_KIX_bdg	433..508	CDD:318810	13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..587		12/53 (23%)
		FOXO-TAD	606..644	CDD:318811	13/43 (30%)
foxo	NP_001262557.1	FH	95..175	CDD:238016	71/79 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4214
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1160384at2759
OrthoFinder	1	1.000	-	-		FOG0000837
OrthoInspector	1	1.000	-	-		otm41061
orthoMCL	1	0.900	-	-		OOG6_108778
Panther	1	1.100	-	-	O	PTHR45767
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4575
SonicParanoid	1	1.000	-	-		X489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860