DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and jumu

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_524302.1 Gene:jumu / 41265 FlyBaseID:FBgn0015396 Length:719 Species:Drosophila melanogaster


Alignment Length:413 Identity:98/413 - (23%)
Similarity:151/413 - (36%) Gaps:125/413 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     4 APASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED 68
            |||:.|..|.|:           |..|......|.:|.....|.......:|:         :|.
  Fly   215 APATMATNSVLQ-----------RRNSSAVDAVRKDLVTELRKAQSSPVPNSL---------EEL 259

Human    69 GGGRAGSAMAIGGGGGSGTL----GSGLL----------LEDSARVLAPGGQDPGSGPATAAGGL 119
            |.|: ||.:.....|.:.|:    |.|.|          |:.::.|.:|||..||:|   :..||
  Fly   260 GKGK-GSTLLNASVGATNTIKLAPGIGGLTFANSAAYQKLKQTSLVKSPGGISPGAG---SNMGL 320

Human   120 ------SGGTQALLQPQ-------QPLPPPQPGAAGGSGQPRKCSSRRNAWGNL----------- 160
                  ..|.||...|:       .|....|...:.||......||..:..||:           
  Fly   321 KREDSNKRGLQASTTPKSIASAANSPHHQMQSNYSLGSPSSLSSSSASSPLGNVSNLVNIANNNT 385

Human   161 -----------------------------SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKD 196
                                         ||:.||..|:::|....|.:|:||.::.:..|||: 
  Fly   386 SGAGSGLVKPLQQKVKLPPVGSPFPKPAYSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFE- 449

Human   197 KGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTG----KSSWWIINPDGGKSGKAPRRRAVSMDNS 257
                |:.:|||||:||||||:..|.:::...|.    |...|.:|||          |...||..
  Fly   450 ----NAPSGWKNSVRHNLSLNKCFEKIERPATNGNQRKGCRWAMNPD----------RINKMDEE 500

Human   258 -NKYTKSRGRAAKKKAALQTA---PESADDSPSQLSKWPGSPTSRSSD-ELDAWTDFRSRTNSNA 317
             .|:::      |..||::.|   |:..:    .|.:......|..|| |||:.::....::...
  Fly   501 VQKWSR------KDPAAIRGAMVYPQHLE----SLERGEMKHGSADSDVELDSQSEIEESSDLEE 555

Human   318 STVSGRLSPIMASTELDEVQDDD 340
            ......:...|...|.||.:|.|
  Fly   556 HEFEDTMVDAMLVEEEDEEEDGD 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 41/175 (23%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 10/41 (24%)
FH_FOXO3 157..239 CDD:410835 32/125 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 17/75 (23%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 3/17 (18%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 11/42 (26%)
FOXO_KIX_bdg 432..511 CDD:465228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
jumuNP_524302.1 COG5025 <254..>523 CDD:227358 74/302 (25%)
FH_FOXN1-like 411..491 CDD:410804 29/84 (35%)
Blue background indicates that the domain is not in the aligned region.

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