DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and FoxK

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_001261701.1 Gene:FoxK / 39252 FlyBaseID:FBgn0036134 Length:760 Species:Drosophila melanogaster


Alignment Length:565 Identity:128/565 - (22%)
Similarity:204/565 - (36%) Gaps:158/565 - (27%)


- Green bases have known domain annotations that are detailed below.


Human     7 SPAPLSPLEV------ELDPEFEPQSRPR---SCTWPLQRPELQASPA---------KPSGETAA 53
            :|.|...|..      :..|..:.|..|.   :...|||:.:.|..||         .|...|| 
  Fly   288 TPLPRDELHQQQLHHHQQQPHLQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTA- 351

Human    54 DSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTL--GSGLLLEDSARVLAPGGQDPGSGPATAA 116
               :.:::.         |:||.:.....|.:..|  |.|..:....::..| .::..|...:..
  Fly   352 ---LHQQQQ---------RSGSIVVAPPAGAAAHLIAGDGPGIYSPLKISIP-KKEQKSPYLSPT 403

Human   117 GGLSGGTQALLQPQQPLPPPQPGAAGGSGQ---------PRKCSSRRNAWGNLSYADLITRAIES 172
            |.:|........|:|.....||......|.         |...|...|.....|||.||.:||.:
  Fly   404 GTISAANSCPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISA 468

Human   173 SPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV---QNEGTGKSSWW 234
            :|||:||||.||.::|:..||::    ..::.||:|||||||||:..|::|   |:| .||.|:|
  Fly   469 APDKQLTLSGIYSFIVKHYPYYR----KETNKGWQNSIRHNLSLNRYFIKVARSQDE-PGKGSFW 528

Human   235 IINPDGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRS 299
            .|:||.|         |..:|:|  |.|.|.|:::........|.||..|||.:.          
  Fly   529 RIDPDSG---------AKLIDHS--YKKRRQRSSQGFRPPYGMPRSAPVSPSHMD---------- 572

Human   300 SDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTV 364
                          ||..|      ||      |.::....||.||.:.....:..|.:      
  Fly   573 --------------NSRES------SP------LQDIVLQSAPGSPGMSLEQRAADPEI------ 605

Human   365 ELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPY--TTKGSGLGSPT 427
                   :..:.|.:....:.....         .|.:.:....|.||..||  |.:.||:.:|.
  Fly   606 -------IYNSQNAHQQQQQQQQQQ---------QQQTLSNNSNQYSSGSPYYVTNQSSGVATPQ 654

Human   428 SSF----------------------NSTVFGPSSLNSL-------RQSPMQTIQENKPATFSSMS 463
            :..                      |..:.|.:|.::|       :|...:.|.|..|..:|  .
  Fly   655 THVEGSAASGGGGGGGVGALLALKRNHVMGGGASQHTLHQQQAVAQQQHSEIIYEELPTDYS--G 717

Human   464 HYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRN 508
            |......:.:.|:     :|..:.:....:|:....|..|..|:|
  Fly   718 HIEASEEECVTTA-----TDATVAKRPKYVSEVLXCVRIQKHRQN 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 33/174 (19%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 5/29 (17%)
FH_FOXO3 157..239 CDD:410835 39/84 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 19/70 (27%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 3/16 (19%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 39/240 (16%)
FOXO_KIX_bdg 432..511 CDD:465228 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
FoxKNP_001261701.1 FHA_FOXK 151..252 CDD:438740
FH_FOXK 453..531 CDD:410800 38/82 (46%)
Blue background indicates that the domain is not in the aligned region.

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