DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and bin

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_523950.2 Gene:bin / 38766 FlyBaseID:FBgn0045759 Length:676 Species:Drosophila melanogaster


Alignment Length:525 Identity:115/525 - (21%)
Similarity:186/525 - (35%) Gaps:138/525 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     2 AEAPASPAPLSPLEVELDP-EFEPQSRPRSCT---------WPLQRPELQASPAKPSGETAADSM 56
            |.:..|.|.:.||:|:|.| ..:..|..:.|:         :.|...:.||...:|       ..
  Fly   156 ASSSTSTAKVQPLQVQLQPLNHQYASTIKYCSNNTILSANDYQLLTSQEQAGQQQP-------QQ 213

Human    57 IPEEEDDEDDEDGGG-----RAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAA 116
            :|.::  .....|||     ....:..|....|...|..               ....|.||.:.
  Fly   214 LPAQQ--LQHSPGGGYMSRISTSPSQVISNAHGMPVLNY---------------SSSSSSPAKSL 261

Human   117 GGLSGGTQALLQPQQPLPPPQ-------PGAA----GGSGQ---------PRKCSSRRNAWGNLS 161
            .|           .:..||.|       .|:|    |||.|         .:|..:||.....||
  Fly   262 NG-----------SESSPPSQNHLENKVSGSAVVGTGGSSQQDAPSTPDTTKKSGTRRPEKPALS 315

Human   162 YADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV-QN 225
            |.::|..||:.||..:||||:||.::.:...:|:     ....|||||:||||||:..|.:: :.
  Fly   316 YINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFR-----GPYVGWKNSVRHNLSLNECFKKLPKG 375

Human   226 EGT---GKSSWWIIN-------PDGGKSGKAPR--RRAVSM----DNSNKYTKS-RGRAAKKKAA 273
            .|.   ||.::|.|:       .|.|...:.||  |..:.:    .::|.|..| .|.|......
  Fly   376 MGVGKPGKGNYWTIDENSAHLFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGN 440

Human   274 LQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEV-- 336
            ...:|..|....|.......||.. .....|.|....:.:.|::..|...:.|:...|.:..:  
  Fly   441 YYASPAFASYDYSAAGATGVSPAG-GQGFADPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAA 504

Human   337 --QDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPS 399
              ..:.:..:|.|..|:..::||.|...:   |.            |....|..|.         
  Fly   505 GGNVNGSATTPPLAHSALGMAPSASSSSS---PL------------GAAATLQSDY--------- 545

Human   400 QPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSP-MQTIQENKPATFSSMS 463
              :||..|:  ::.:.|.|....|.:...|.           ||:|.| :.:||..:....:...
  Fly   546 --APTASLV--AAGYSYATSAGSLDNGLRSI-----------SLQQLPGLSSIQHAQAQAQAQAH 595

Human   464 HYGNQ 468
            |:.:|
  Fly   596 HHHHQ 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 35/185 (19%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 2/27 (7%)
FH_FOXO3 157..239 CDD:410835 32/92 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 17/84 (20%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 3/22 (14%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 31/174 (18%)
FOXO_KIX_bdg 432..511 CDD:465228 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
binNP_523950.2 FH_FOX 312..391 CDD:469596 32/83 (39%)
Blue background indicates that the domain is not in the aligned region.

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