DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and FoxL1

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_523912.1 Gene:FoxL1 / 38471 FlyBaseID:FBgn0004895 Length:365 Species:Drosophila melanogaster


Alignment Length:394 Identity:99/394 - (25%)
Similarity:153/394 - (38%) Gaps:125/394 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   127 LQPQQPLPPPQPGAAGGSG-QPRKCSS----------------RRNAWG---------------N 159
            |:.|....|..|.|.||:| :...|.|                ..|.||               .
  Fly    29 LRTQVSPNPLAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEKPP 93

Human   160 LSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRV- 223
            .||..||..||.|:|::|||||.||::::...||:::     :..||:|||||||||:..|::: 
  Fly    94 FSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRE-----NKQGWQNSIRHNLSLNDCFVKIP 153

Human   224 -------QNEGTGKSSWWIIN---PDGGKSGKAPRRRAVSM---DNSNKYTKSRGRAA----KKK 271
                   .|:..||.|:|:::   .|..:.|...|||....   .:.|:|.:..|:.:    ...
  Fly   154 RDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSA 218

Human   272 AALQTAPESADDSPSQLSKWPGSPTSRSSD----ELDAWTDFRSRTNSNASTVSGRLSPIMASTE 332
            |.:::..|...|.....::.| :.:.|.:|    .|.....|.|..|:.|.    .|.|:   .|
  Fly   219 AEIRSPSEPLSDFDIFCNERP-NYSDRITDLHRQYLSVSLGFNSLFNNEAR----GLRPL---PE 275

Human   333 LDEVQDD-DAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITL 396
            :.|..|| ||       |||:|.:                |..:|.|::.|..            
  Fly   276 IRECPDDVDA-------SSSSSKA----------------MQSSMELHEELHS------------ 305

Human   397 PPSQPSPTGGLMQRSSSFPYTTKGSGLGSP--TSSFN---STVFGPSSLNSLRQSPMQTIQENKP 456
             ||..:|.....:.|||          |:|  ..:||   ..|..|.|      ||:.:...:|.
  Fly   306 -PSAFTPPLNRRETSSS----------GAPVLAEAFNGIKDVVDAPGS------SPVASSNRSKT 353

Human   457 ATFS 460
            ..|:
  Fly   354 TLFT 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 10/42 (24%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 36/107 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 16/84 (19%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 4/19 (21%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 39/171 (23%)
FOXO_KIX_bdg 432..511 CDD:465228 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
FoxL1NP_523912.1 FH_FOX 89..186 CDD:469596 36/101 (36%)
Blue background indicates that the domain is not in the aligned region.

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