DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FOXO3 and fd59A

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_523814.1 Gene:fd59A / 37631 FlyBaseID:FBgn0004896 Length:456 Species:Drosophila melanogaster


Alignment Length:391 Identity:97/391 - (24%)
Similarity:137/391 - (35%) Gaps:132/391 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    84 GSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPR 148
            |..::|:|:....|:|..|......|...:.......||:               |||||:|...
  Fly    27 GGSSIGNGIGCSASSRTAAADAMSMGCDDSDIEPSSMGGS---------------GAAGGNGDGS 76

Human   149 KCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHN 213
            ..|.........||..|||.||..||.|:||||.|.::::...||:|||     ...|:||||||
  Fly    77 GSSGGPLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDK-----FPAWQNSIRHN 136

Human   214 LSLHSRFMRVQNE--GTGKSSWWIINP------DGGKSGKAPRR--RAVSMD------------- 255
            |||:..|::|..|  ..||.::|.::|      |.|...:..:|  ||.:|.             
  Fly   137 LSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRAPTMQRFSFPAVFGTLSP 201

Human   256 --------------NSNKYTKSRG---------------RAAKK-------KAALQTAPESADDS 284
                          |...:..||.               ||.||       :|:.....:|.|  
  Fly   202 FWIRKPVPLVPVHFNVPNFNGSREFDVVHNPADVFDSALRADKKFNFFANAEASFYQGSQSGD-- 264

Human   285 PSQLSKWPGSPTSRSSDELDAWTD-------------------------FRSRTNSNASTVSG-- 322
              :..:.|.....|.:|.|||...                         |...|.::|:.:.|  
  Fly   265 --KFDRLPFMNRGRGADVLDALPHSSGSGGGVGGGSESSRGSKYKSPYAFDVATVASAAGIPGHR 327

Human   323 ----RLSP---IM--------ASTELD-EVQDDDAPLSPMLYSSSAS------LSPSVSKPCTVE 365
                |||.   .|        |.||.| |.:.||......:...|.:      :|.||...||..
  Fly   328 DYAERLSAGGGYMDLNVYNDDADTEADAEAEGDDDSCEDKIDVESGNEQEDSHISDSVDSACTNR 392

Human   366 L 366
            |
  Fly   393 L 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 16/68 (24%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 6/23 (26%)
FH_FOXO3 157..239 CDD:410835 37/89 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 20/127 (16%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 5/45 (11%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 26/116 (22%)
FOXO_KIX_bdg 432..511 CDD:465228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
fd59ANP_523814.1 FH_FOXD4-like 85..180 CDD:410822 39/99 (39%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.