Protein Alignment FOXO3 and slp1

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_476730.1
• Gene: slp1 / 33607
• FlyBaseID: FBgn0003430
• Length: 322
• Species: Drosophila melanogaster
• Alignment Length: 192
• Identity: 54/192 - (28%)
• Similarity: 91/192 - (47%)
• Gaps: 40/192 - (20%)

Human   161 SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN 225
            ||..||..||:.||::||||:.||::::...||||     .:..||:|||||||||:..|.::..
  Fly   124 SYNALIMMAIQDSPEQRLTLNGIYQYLINRFPYFK-----ANKRGWQNSIRHNLSLNKCFTKIPR 183

Human   226 --EGTGKSSWWIINPD------GGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESAD 282
              :..||.::||::|.      |..:||..|:...:         ||.|.|..:.|:.:...:|.
  Fly   184 SYDDPGKGNYWILDPSAEEVFIGETTGKLRRKNPGA---------SRTRLAAYRQAIFSPMMAAS 239

Human   283 --DSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAP 342
              .:|:....:|..|.:.::                |:.:..|::|........::|...||
  Fly   240 PYGAPASSYGYPAVPFAAAA----------------AAALYQRMNPAAYQAAYQQMQYQQAP 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108
		FH_FOXO3	157..239	CDD:410835	34/79 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		16/78 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		3/16 (19%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		6/43 (14%)
		FOXO_KIX_bdg	432..511	CDD:465228
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587
		FOXO-TAD	606..644	CDD:435506
slp1	NP_476730.1	COG5025	<11..>230	CDD:227358	43/119 (36%)
		Forkhead	120..205	CDD:459732	35/85 (41%)