Protein Alignment FOXO3 and fd19B

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_608369.1
• Gene: fd19B / 33010
• FlyBaseID: FBgn0031086
• Length: 260
• Species: Drosophila melanogaster
• Alignment Length: 156
• Identity: 48/156 - (30%)
• Similarity: 74/156 - (47%)
• Gaps: 32/156 - (20%)

Human   130 QQPLPPPQPGAAGGSGQPRKCSS------------RRNAWGNLSYADLITRAIESSPDKRLTLSQ 182
            :.|:.....|::..|     |||            :.||....:|:.||..||.||.:||||||.
  Fly    24 ESPISKHNSGSSFSS-----CSSSSSNSSSDSMAAKSNAKPAFTYSALIVMAIWSSSEKRLTLSG 83

Human   183 IYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN--EGTGKSSWWIINP------D 239
            |.:|:....||::.:     .:.|:|||||||||:..|:||..  :..|:..:|.::|      .
  Fly    84 ICKWIADNFPYYRTR-----KSVWQNSIRHNLSLNPFFVRVPRALDDPGRGHYWALDPYAEDLSI 143

Human   240 GGKSGKAPRRRAVSMDNSNKYTKSRG 265
            |..:|:.  ||:....|:....|..|
  Fly   144 GETTGRL--RRSNWQQNTGARPKVTG 167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		6/34 (18%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108
		FH_FOXO3	157..239	CDD:410835	33/89 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		9/41 (22%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		4/16 (25%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673
		FOXO_KIX_bdg	432..511	CDD:465228
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587
		FOXO-TAD	606..644	CDD:435506
fd19B	NP_608369.1	Forkhead	58..140	CDD:459732	33/86 (38%)