DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and CG32006

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_726538.1 Gene:CG32006 / 317817 FlyBaseID:FBgn0052006 Length:443 Species:Drosophila melanogaster


Alignment Length:297 Identity:67/297 - (22%)
Similarity:111/297 - (37%) Gaps:78/297 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   161 SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN 225
            :|:.:|..|:  ..:.|:||.|:..|:.....:|:.:      ..|.||||||||||..|...:.
  Fly   150 NYSHIIGMAM--LQNGRITLQQLCSWIEAKFAFFRVR------KKWNNSIRHNLSLHHCFRNRKR 206

Human   226 EGTGKSSWWIINPDGGK-SGKAPRRRAVSMDNSNKYTK---------SRGRAAK-------KKAA 273
            |..||..:|.:..|..| ..|..|.|.:.....|:..|         .:.::|:       ||:.
  Fly   207 EERGKGGYWELGVDPKKCDRKRIRNRKIFHPTQNQTAKLQYEHLTEIQQAKSARKNHSRHIKKSK 271

Human   274 LQTAPESAD------------------DSPSQLSKWPGSPTSRSSDELDA--------WTDFRSR 312
            ..:.||:::                  |...||.........:...|||.        .|:.::.
  Fly   272 TSSLPETSEANIFNVVPHKKHNIADENDGQRQLQTINKDDILKKKSELDTIVSSTESFLTESQNL 336

Human   313 TNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSS-----ASLSPSV---SKPCTV----- 364
            ...|:.......:||.|........:..:.::|:|.|:|     .::|..|   |.||.:     
  Fly   337 NCFNSHKTDTTNTPISAEKNFCTFNNFYSEMTPVLASNSNIVEDQNVSTDVSWPSHPCNITINYD 401

Human   365 -------------ELPRLTDMAGTMNLNDGLTENLMD 388
                         :...|.|.|| .:.||.:.|||:|
  Fly   402 YTNFQPIVDSIAEQFQCLHDSAG-YDRNDDILENLLD 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 25/77 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 16/105 (15%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 4/17 (24%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 27/123 (22%)
FOXO_KIX_bdg 432..511 CDD:465228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587
FOXO-TAD 606..644 CDD:435506
CG32006NP_726538.1 Forkhead 146..217 CDD:459732 25/74 (34%)
Blue background indicates that the domain is not in the aligned region.

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