Protein Alignment FOXO3 and CHES-1-like

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_511071.3
• Gene: CHES-1-like / 31678
• FlyBaseID: FBgn0029504
• Length: 1268
• Species: Drosophila melanogaster
• Alignment Length: 723
• Identity: 156/723 - (21%)
• Similarity: 242/723 - (33%)
• Gaps: 222/723 - (30%)

Human    32 TWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGS------ 90
            |..||...||.|.:.|     ..:|.|..:.......|||..|.....|||||...|.|
  Fly   569 TTTLQARSLQLSVSPP-----PPNMTPTSQVHNGSLGGGGGGGGGSGGGGGGGGANLRSPNSYAS 628

Human    91 ----------GLLLEDSARVLAP-------GGQDPGSGPATAAGGLSGGTQALLQ------PQQP 132
                      .|::........|       |....|:|.:...|..:|......|      |..|
  Fly   629 YDNEDSLKEFDLVVSSRLHTSTPQYSVSKNGANGYGNGNSNVNGSGAGSNTPQKQKHPNNVPYDP 693

Human   133 L-----PPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVP 192
            |     .||                       .|::.||..|||.|.:|.|.:.:||.|:|:..|
  Fly   694 LVHTNNKPP-----------------------YSFSSLIFMAIEGSNEKALPVKEIYAWIVQHFP 735

Human   193 YFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN-EGTGKSSWWIINPDGGKSGKAPRRRAVSMDN 256
            |||     .:..|||||:||||||:..|::|:. ...||.|.|.:.|.       .|:..:...|
  Fly   736 YFK-----TAPNGWKNSVRHNLSLNKSFVKVEKAPNMGKGSLWRVEPQ-------QRQNLIQALN 788

Human   257 SNKYTKSRGRAAKKKAALQTAPESADD--SPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNAST 319
            .:.:                .|.||.|  |||..|...||    :.|.||..   .|.:.|:|..
  Fly   789 RSPF----------------FPNSAVDKISPSLKSPSGGS----AYDSLDGG---GSGSVSSAQP 830

Human   320 VSGRLS-PIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVE--------------LPRL 369
            |:|... |..|:..|......:.    :..::.||.:.:.::|.:..              .|.|
  Fly   831 VAGGAGVPAAAAVALSTPTKSNG----LALANGASQATNAARPHSPNGGGSGSHARFDPYLFPNL 891

Human   370 T--------DMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGS----- 421
            :        |..|...|.|.|.:.|..|..:|              ...:|...|...|:
  Fly   892 SKAFRNIREDTVGQPMLQDALDDELSGDYHNN--------------NNNNSGSKYNYMGANGSGG 942

Human   422 ----GLGSPTSSFNSTV--------FGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLL 474
                |:||..:..:..:        .|..|::.:..:......::.|..:|.....|:..:  :.
  Fly   943 AGSGGVGSNANGASDGINFARLARDCGADSIDDVHAAAAMLYLKHGPKIYSEPFQNGSGPV--IT 1005

Human   475 TSDSLSH-------------SDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQG 526
            :|.|..|             |...:|..:.|.|.|......||::......::...|.||.  ..
  Fly  1006 SSPSEDHTYSAGGNSNADSGSSTPLTNGNALASVAQAVAQGQNNQGGAGSDSNCASSDAAY--DS 1068

Human   527 SLVNQNLL-----------------------------------HHQHQTQGALGGS---RALSNS 553
            |..|.|:.                                   :|.:.:.|:..||   ||.|:|
  Fly  1069 SEENHNITPEEMADRQRHRDGVDALLSLSGSSIVECGSVATTHYHSNGSSGSSHGSPHKRASSHS 1133

Human   554 VSNMGLSE--SSSLGSAKHQQQSPVSQ--SMQTLSDSLSGSS---LYSTSANLPVMGHEKFPSDL 611
            :....|.:  ...|...:.|||....|  |.|.:..:.|||.   |.|.:||:.:...::  ..:
  Fly  1134 LEEEHLQQHREQQLQQQQQQQQHHHQQFGSSQAVYTNGSGSKMALLSSAAANVALAQQQQ--QQI 1196

Human   612 DLDMFNGS 619
            ..||::.:
  Fly  1197 HQDMYSST 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		33/154 (21%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108		10/50 (20%)
		FH_FOXO3	157..239	CDD:410835	34/82 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		15/72 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		2/16 (13%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		76/418 (18%)
		FOXO_KIX_bdg	432..511	CDD:465228	15/99 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587		16/57 (28%)
		FOXO-TAD	606..644	CDD:435506	2/14 (14%)
CHES-1-like	NP_511071.3	FH_FOXN2-like	700..775	CDD:410805	36/102 (35%)