Protein Alignment FOXO3 and foxo3b

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_571160.1
• Gene: foxo3b / 30296
• ZFINID: ZDB-GENE-990708-6
• Length: 651
• Species: Danio rerio
• Alignment Length: 703
• Identity: 404/703 - (57%)
• Similarity: 484/703 - (68%)
• Gaps: 82/703 - (11%)

Human     1 MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKP-SGETAADSMIPEEEDDE 64
            |||....  |||.|::.:||:||||.|||||||||  ||  :|.||| |.:|   .:||||||||
Zfish     1 MAETTLE--PLSSLDIAIDPDFEPQKRPRSCTWPL--PE--SSMAKPASNDT---DIIPEEEDDE 56

Human    65 DDEDGGGRAGSAMAIGGGG-GSG-TLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALL 127
            ||        |||.|...| |.| ..||..|.|:   :::..||:....|.::..  :..|.|
Zfish    57 DD--------SAMTINANGMGEGEDNGSPSLAEE---LISINGQENTGSPLSSQA--ASATTA-- 106

Human   128 QPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVP 192
                     .|..|.....|||.|||||||||||||||||:||||:|||||||||||:|||..||
Zfish   107 ---------SPEVASQQQTPRKSSSRRNAWGNLSYADLITKAIESTPDKRLTLSQIYDWMVSSVP 162

Human   193 YFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNS 257
            ||||||||||||||||||||||||||||:|||||||||||||:|||:||:.|||||||||||||.
Zfish   163 YFKDKGDSNSSAGWKNSIRHNLSLHSRFIRVQNEGTGKSSWWMINPEGGRGGKAPRRRAVSMDNG 227

Human   258 NKYTK-SRGRAAKKKAALQTAPESA--DDSPSQLSKWPGSPTSRSSDELDA-WTDFRSRTNSNAS 318
            ||||| :||||||||||||.|.|.:  :.|...|||||||||||||||.:: |||||||||||||
Zfish   228 NKYTKTARGRAAKKKAALQAAQEGSLENISAGGLSKWPGSPTSRSSDEQESCWTDFRSRTNSNAS 292

Human   319 TVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSP-----SVSKPCTVELPRLTDMAGTMNL 378
            |||||||||:|:.|||:| .|..||||:||||.:||||     |.||.|..|||.|.|:.|||||
Zfish   293 TVSGRLSPILANPELDDV-SDGPPLSPILYSSPSSLSPPSSTSSNSKTCPGELPVLADLTGTMNL 356

Human   379 NDGLTENLMDDLLDNI-----TLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPS 438
            |:  .:|||.||||||     .:..|.|...|.  :.::|.|.|:....:.:.|..|::.:||||
Zfish   357 NE--ADNLMVDLLDNIATQVQVVQESSPFSFGS--KSTASPPSTSTSQTVSNNTGGFSNPIFGPS 417

Human   439 SLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSL---SHSDVMMTQSDPLMSQASTAV 500
            . .||||.|||||||||..:|||:|.: ..:|||||.||||   |||||||||||||:||||.||
Zfish   418 P-GSLRQKPMQTIQENKQTSFSSISCF-ETSLQDLLNSDSLVSHSHSDVMMTQSDPLISQASAAV 480

Human   501 SAQN--SRRNVMLRNDPMM-SFAAQPNQGSLVNQNLLHHQHQT-QGALGGSRALSNSVSNMGLSE 561
            ::||  .|.|.|||||||| ||::..|..|...||..|||... ||:|   |:|||:.:...:::
Zfish   481 TSQNYRLRNNPMLRNDPMMSSFSSVLNGRSGHLQNKQHHQGSNGQGSL---RSLSNNRAQSLVND 542

Human   562 SSSLGSAKH--QQQSPVSQSMQTLSDSLSGSSLYSTSANLPV---MGHEKFPSDLDLDMFNGSLE 621
            :::|.|||.  |.|..:..:...|...::||:      .|.:   .|.::||||||||:|||||:
Zfish   543 ANNLVSAKQLLQPQPTMLMTETPLYSGMNGSN------GLGICHPSGTDRFPSDLDLDIFNGSLD 601

Human   622 CDMESIIRSELMDADGLDFNFDSLISTQNVVGLN-VGNFTGAKQASSQSWVPG 673
            ||::|||||||||:||||||||:|:  ||.|.|| ||||||.|| |:.|||||
Zfish   602 CDVDSIIRSELMDSDGLDFNFDALM--QNAVSLNPVGNFTGTKQ-SNHSWVPG 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		62/154 (40%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108		9/29 (31%)
		FH_FOXO3	157..239	CDD:410835	74/81 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		55/73 (75%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		13/16 (81%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		213/396 (54%)
		FOXO_KIX_bdg	432..511	CDD:465228	53/83 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587		16/53 (30%)
		FOXO-TAD	606..644	CDD:435506	31/37 (84%)
foxo3b	NP_571160.1	FH_FOXO1	118..216	CDD:410834	86/97 (89%)
		FOXO_KIX_bdg	411..493	CDD:465228	53/83 (64%)
		FOXO-TAD	586..624	CDD:435506	31/37 (84%)