Protein Alignment FOXO3 and Foxo3

DIOPT Version :10

• Sequence 1: NP_001446.1
• Gene: FOXO3 / 2309
• HGNCID: 3821
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_001099865.1
• Gene: Foxo3 / 294515
• RGDID: 1309196
• Length: 672
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 636/673 - (94%)
• Similarity: 650/673 - (96%)
• Gaps: 1/673 - (0%)

Human     1 MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDED 65
            ||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat     1 MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDED 65

Human    66 DEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQ 130
            |||.|||..|||.| |||.|..||||||||||||:|:|||||.|:|||::||.||||||..||||
  Rat    66 DEDSGGRGSSAMVI-GGGVSSALGSGLLLEDSARLLSPGGQDLGTGPASSAGALSGGTQTQLQPQ 129

Human   131 QPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   130 QPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFK 194

Human   196 DKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKY 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 DKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNSNKY 259

Human   261 TKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLS 325
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 TKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLS 324

Human   326 PIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDL 390
            ||:||||||:|||||.|||||||||||||||||||||||||||||||||||||||||.|||||||
  Rat   325 PILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAENLMDDL 389

Human   391 LDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENK 455
            ||||.|||||.||.|||||||||||||.|.|||||||||||||||||:||||||||||||||||:
  Rat   390 LDNIALPPSQASPPGGLMQRSSSFPYTAKSSGLGSPTSSFNSTVFGPASLNSLRQSPMQTIQENR 454

Human   456 PATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFA 520
            ||||||:||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   455 PATFSSVSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFA 519

Human   521 AQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSD 585
            |||.||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   520 AQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPVSQSMQTLSD 584

Human   586 SLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQN 650
            |||||||||.|||||||||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   585 SLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQN 649

Human   651 VVGLNVGNFTGAKQASSQSWVPG 673
            |||||||||||||||||||||||
  Rat   650 VVGLNVGNFTGAKQASSQSWVPG 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO3	NP_001446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..153		132/151 (87%)
		Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301	80..108		21/27 (78%)
		FH_FOXO3	157..239	CDD:410835	81/81 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..302		69/70 (99%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193	242..259		16/16 (100%)
		Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260	300..673		355/372 (95%)
		FOXO_KIX_bdg	432..511	CDD:465228	74/78 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..587		49/50 (98%)
		FOXO-TAD	606..644	CDD:435506	37/37 (100%)
Foxo3	NP_001099865.1	FH_FOXO3	156..238	CDD:410835	81/81 (100%)
		FOXO_KIX_bdg	431..510	CDD:465228	74/78 (95%)
		FOXO-TAD	605..643	CDD:435506	37/37 (100%)