DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and fhl1

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_594272.1 Gene:fhl1 / 2541552 PomBaseID:SPAC1142.08 Length:743 Species:Schizosaccharomyces pombe


Alignment Length:661 Identity:148/661 - (22%)
Similarity:216/661 - (32%) Gaps:257/661 - (38%)


- Green bases have known domain annotations that are detailed below.


Human     4 APASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED 68
            :|:|...|||         :|..||.|...|::                .||.:...:....||:
pombe   222 SPSSIQRLSP---------QPYVRPTSDERPIE----------------TDSSVSAPKVANHDEE 261

Human    69 GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPG-GQDPGSGPATAAGGLSGGTQALLQPQQP 132
                               |..|.....|..||.|. ...|.:|.||               |:|
pombe   262 -------------------LKQGKSTSPSDTVLHPDLNGSPDTGDAT---------------QKP 292

Human   133 LPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDK 197
                                      |||||:||.|.:.::|:|::||..|.||:.....|::  
pombe   293 --------------------------NLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYR-- 329

Human   198 GDSNSSAGWKNSIRHNLSLHSRFMRV---QNEGTGKSSWWIINPD--GGKSGKAPRRRAVSMDNS 257
               :....|.|||||||||:..|:|:   ||| .||.|:|:::|.  ....|...||       :
pombe   330 ---HQPPAWHNSIRHNLSLNKAFIRIPRRQNE-PGKGSFWMLDPSYIDQFEGNFFRR-------T 383

Human   258 NKYTKSRGRAA-------KKKAALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNS 315
            .|.|.|...||       .:.||:||...||..: .||:  |...||||........:...|.. 
pombe   384 KKPTPSATPAAHPDTARENELAAIQTKGISAGKT-EQLN--PQKETSRSKTHTSRGENVEDRPQ- 444

Human   316 NASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSS---------------ASLSPSVSK---PC 362
              |.:...:.||:       ::|....|:|..:.::               :.|...::|   |.
pombe   445 --SLLQNGIQPII-------MRDGKLALNPEFFKNANGEQQAPNEQAVQAISLLQQHINKQLGPA 500

Human   363 TVELP--------------------RLTDMAG---------------TMNLNDGLTENLMDDLLD 392
            ....|                    :.|.|.|               :..||...|  .|..  .
pombe   501 AANNPEQATAIANALAVALAQKLQKQQTQMQGPQQVQQQAKRRKAYTSQQLNPAPT--AMPH--P 561

Human   393 NITLPPSQPSPTGGLMQR---------------SSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNS 442
            |||    .|||:..:.||               .|..|.|.:..|...|..:..:...||||:.|
pombe   562 NIT----SPSPSISVTQRPAVNVGPPPYVRPSAPSKLPDTRQSIGDPLPPGAMANVSAGPSSVRS 622

Human   443 --------------LRQSPMQTIQENKPAT-----FSSMSHYGNQTLQDLLTSDSLSHSDVMMTQ 488
                          .....:.||..|||.|     :||    .|.||:.:.|.:           
pombe   623 SSYNSTASESKSEITSHQNLHTIPINKPFTSDRPLYSS----PNDTLERVETGN----------- 672

Human   489 SDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNS 553
            ....|:....|.|.  |:|::|...:.  ||......|:.|:.                   |:|
pombe   673 QGQRMNSIGNASSF--SKRDIMENENG--SFDTNAKNGNNVDD-------------------SSS 714

Human   554 VSNMGLSESSS 564
            |..|.|..:||
pombe   715 VRGMNLPSNSS 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 26/149 (17%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108 6/28 (21%)
FH_FOXO3 157..239 CDD:410835 35/84 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 24/79 (30%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 3/16 (19%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 65/352 (18%)
FOXO_KIX_bdg 432..511 CDD:465228 22/97 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 7/29 (24%)
FOXO-TAD 606..644 CDD:435506
fhl1NP_594272.1 COG5025 1..564 CDD:227358 102/456 (22%)
Blue background indicates that the domain is not in the aligned region.

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