DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and sep1

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_596301.1 Gene:sep1 / 2540866 PomBaseID:SPBC4C3.12 Length:663 Species:Schizosaccharomyces pombe


Alignment Length:579 Identity:138/579 - (23%)
Similarity:214/579 - (36%) Gaps:194/579 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   129 PQQPLPPP-----------QPGAAGGSGQ-PRKC-----SSRRNAWGNLSYADLITRAIESSPDK 176
            |..|:|||           .|..:....| |.:.     ..::..:   |||.||..:|..|||:
pombe    86 PPLPIPPPSEQSLDTIIYRNPSVSSSQSQEPEEFFLPLDDGKKPPY---SYAMLIGMSIIRSPDR 147

Human   177 RLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGT--GKSSWWIINP- 238
            |||||.||:|:.....::     :.|:.||:|||||||||:..||:::....  ||..:|.|.| 
pombe   148 RLTLSAIYDWISNTFSFY-----NKSNNGWQNSIRHNLSLNKAFMKIERPRNLPGKGHFWSIRPG 207

Human   239 ------------DGGKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKW 291
                        .|..|..||..:.|:  :|.||..|.|.:...  ...|:|...:.....|..:
pombe   208 HEEQFLKLKLRKPGVNSRPAPPVQDVT--SSTKYGSSTGSSGFN--TFNTSPHIFNQRHQYLQNY 268

Human   292 -----PGSPTSRS-----------------SDELDAWTDFRSR-TNSNASTVSGRLSPIMASTEL 333
                 ...||..:                 :..:||.:|..:: ::...|:|....||:.:.|  
pombe   269 YTASLTNIPTISNVNATNFHPLHSQQPYVDTPGIDAPSDLEAKFSDLGVSSVVSVTSPLQSCT-- 331

Human   334 DEVQDDDAPLSPMLYSSSASLSPSVS-------------------------KPCT-----VELPR 368
                  ::| ||.|.|.::|.|||.|                         .|.:     ||.|.
pombe   332 ------NSP-SPPLSSPASSASPSESLRNESLGIKSAKSLGLNKDDAPVEGPPVSHLEKDVETPS 389

Human   369 LTDMA----------GTMNLNDGLTENLMDDLLDNITLP--PSQP---SPTGGLMQRSSSFPYTT 418
            :.|..          |...|.||.|..|.   :..:.||  ||.|   :|:|.|::||:|..:.|
pombe   390 VHDSVLGFNDTVTNLGKKGLKDGTTNTLQ---IPAVRLPSLPSSPTIKNPSGLLLKRSNSIDFPT 451

Human   419 KGSGLGSPTSSFNSTVFGP------------SSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQ 471
            ....|......|...:...            |.::.:..||...::|::           .:.||
pombe   452 PPKALCPKLFCFRDDIVADDYTKFSLLSPIRSDMSGISASPNTNLKEHR-----------TRILQ 505

Human   472 DLLTSD-----SLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRN---DPMMSFAAQPNQGSL 528
            .|.|.|     ||:.||.......||.|.              :|||   ...::.:..|...||
pombe   506 MLATPDAKQLSSLTSSDAEFWSVTPLKSS--------------ILRNGDASKQVTLSESPKGDSL 556

Human   529 VNQNLLHHQHQTQGALGGSRA-LSNSVSNM-GLSESSSLGSAKHQQQSPVSQSMQTLSD 585
            ::              |||.: .:|::|:: ||...|.|         |:|:|..|..|
pombe   557 LD--------------GGSLSYFTNNISSVAGLETPSKL---------PMSKSFDTFED 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 8/40 (20%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 36/96 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 18/105 (17%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 5/16 (31%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 79/354 (22%)
FOXO_KIX_bdg 432..511 CDD:465228 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 14/52 (27%)
FOXO-TAD 606..644 CDD:435506
sep1NP_596301.1 COG5025 20..663 CDD:227358 138/579 (24%)
Blue background indicates that the domain is not in the aligned region.

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