DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and mei4

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_595617.1 Gene:mei4 / 2540241 PomBaseID:SPBC32H8.11 Length:517 Species:Schizosaccharomyces pombe


Alignment Length:512 Identity:133/512 - (25%)
Similarity:197/512 - (38%) Gaps:146/512 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   161 SYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQN 225
            |||.||..||..|.:|:||||.||.|:.....|:     .|...||:|||||||||:..|::|:.
pombe    85 SYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYY-----LNHDGGWQNSIRHNLSLNKAFIKVEK 144

Human   226 -EG-TGKSSWWIINPDGGKSGKAPR-RRAVSMD-NSNKYTKSRGRAAKKKAALQTAPESADDSPS 286
             :| |.|..:|.|:||..::..:.| .|:.|.| ||.|...|:....|.....:.          
pombe   145 PKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSKKRPSSKCHEIKPLTTREI---------- 199

Human   287 QLSKWPGSPTSRSSDELDAWTDFRSRTNS-NAST-VSGRLSPIMASTELDEVQDDD--------- 340
                    |.:|.          |||.|| |:|| .||..|.:.|....|..|..:         
pombe   200 --------PLARK----------RSRLNSFNSSTSTSGSSSNVAAEVSNDASQPSNQDSSLNSNI 246

Human   341 --APLSPMLYSSSASLSPSVSKP---CTVELPRLTDMAGTMNLND-GLTENLMDDLLDNITLPPS 399
              .||.|....|::|.|.:|.||   ...:||       |::.:: .|.||:.|..|..:....:
pombe   247 VKPPLPPSNVQSNSSSSENVPKPNAETQEDLP-------TIDAHESSLYENVNDSRLYEVPACRN 304

Human   400 QPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSH 464
            ....||          |:....|       :..|.|..:|.|||   |....:|           
pombe   305 MALNTG----------YSDADPG-------YLRTSFRSNSHNSL---PYSANEE----------- 338

Human   465 YGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRN-----------VMLRNDPMMS 518
                  :|:|             |:|.|:||.|:.||:..|.|:           :.||......
pombe   339 ------EDVL-------------QADFLVSQQSSMVSSYVSSRDPHSMPYYRREPIPLRPSSRFY 384

Human   519 FAAQPNQGSLVNQNLLHHQHQTQGALGG---SRALSNSVSNMGLSE----SSSLGSAKHQQQSPV 576
            ...:|..|          :..|..:..|   |..:::..|.:..|:    |.:|...||::....
pombe   385 EYTRPTYG----------RTDTSCSAPGAFCSTQINSPSSYINYSKCAPSSPTLSLQKHREHVKS 439

Human   577 SQSMQTLSDSLSGSSLYSTSANL---PVMGHEKFPSDLD----LDMFNGSLECDMES 626
            ...:..|:.|..||..::.|:.|   |:.....|.|.||    :..|..|.|.:.||
pombe   440 LLYVPDLTPSFDGSDPWNPSSQLLSEPLFDQHSFQSSLDDLMSVTCFRDSPELNHES 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 36/79 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 15/72 (21%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 6/18 (33%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 84/369 (23%)
FOXO_KIX_bdg 432..511 CDD:465228 20/89 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 10/57 (18%)
FOXO-TAD 606..644 CDD:435506 9/25 (36%)
mei4NP_595617.1 COG5025 1..517 CDD:227358 133/512 (26%)
Blue background indicates that the domain is not in the aligned region.

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