DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO3 and daf-16

DIOPT Version :10

Sequence 1:NP_001446.1 Gene:FOXO3 / 2309 HGNCID:3821 Length:673 Species:Homo sapiens
Sequence 2:NP_001367893.1 Gene:daf-16 / 172981 WormBaseID:WBGene00000912 Length:541 Species:Caenorhabditis elegans


Alignment Length:580 Identity:173/580 - (29%)
Similarity:230/580 - (39%) Gaps:218/580 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   117 GGLSGGTQALLQP-------QQPLP-------PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLIT 167
            |..|.|:.|:|..       |...|       .|....:|     :|.::|||||||:|||:|||
 Worm   126 GASSNGSTAMLHTPDGSNSHQTSFPSDFRMSESPDDTVSG-----KKTTTRRNAWGNMSYAELIT 185

Human   168 RAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSS 232
            .||.:||:|||||:|:|||||:.||||:|||||||||||||||||||||||||||:||||.||||
 Worm   186 TAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSS 250

Human   233 WWIINPDGGKSGKAPRR---RAVSMDNSNK--YTKSRGRAAKKK--------------------A 272
            ||:|||| .|.|:.|||   |:.:::.:.|  ..||| |.|||:                    .
 Worm   251 WWVINPD-AKPGRNPRRTRERSNTIETTTKAQLEKSR-RGAKKRIKERALMGSLHSTLNGNSIAG 313

Human   273 ALQTAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNAST--VSGRLSPIMASTELDE 335
            ::||......|..|....:...|:|           ||.||.||.|.  .|.|:||.:.|...|:
 Worm   314 SIQTISHDLYDDDSMQGAFDNVPSS-----------FRPRTQSNLSIPGSSSRVSPAIGSDIYDD 367

Human   336 VQDDDAPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQ 400
            ::      .|.....|....||          .:.|....|.: |..|.                
 Worm   368 LE------FPSWVGESVPAIPS----------DIVDRTDQMRI-DATTH---------------- 399

Human   401 PSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHY 465
               .||:..:..|.|..|:..   :|..|::       .|||:|.|..|                
 Worm   400 ---IGGVQIKQESKPIKTEPI---APPPSYH-------ELNSVRGSCAQ---------------- 435

Human   466 GNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRND--PMMSFAAQPNQGSL 528
                                                      |.:|||.  |..:|...|..|:.
 Worm   436 ------------------------------------------NPLLRNPIVPSTNFKPMPLPGAY 458

Human   529 VN-QNLLHHQHQTQGALGGSRAL-----SNSVSNMGLSESSSLGSAKHQQQS----PVSQSMQTL 583
            .| ||            ||...:     |||....|: :|..:.:|:|...|    |:.....||
 Worm   459 GNYQN------------GGITPINWLSTSNSSPLPGI-QSCGIVAAQHTVASSSALPIDLENLTL 510

Human   584 SDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFD 643
            .|.             |:|.                 ..|::::||.||..|.|...:||
 Worm   511 PDQ-------------PLMD-----------------TMDVDALIRHELSQAGGQHIHFD 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO3NP_001446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..153 10/49 (20%)
Required for mitochondrial import. /evidence=ECO:0000269|PubMed:23283301 80..108
FH_FOXO3 157..239 CDD:410835 67/81 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..302 28/95 (29%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:17940099, ECO:0000269|PubMed:29445193 242..259 6/19 (32%)
Mediates interaction with CHUK/IKKA and IKBKB/IKKB. /evidence=ECO:0000269|PubMed:15084260 300..673 70/358 (20%)
FOXO_KIX_bdg 432..511 CDD:465228 7/78 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..587 14/59 (24%)
FOXO-TAD 606..644 CDD:435506 9/38 (24%)
daf-16NP_001367893.1 FH_FOXO 176..255 CDD:410806 64/78 (82%)
Blue background indicates that the domain is not in the aligned region.

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