|
Human 95 SKWALGRLLGVLLHEEAGDSGFVSLSRLGPSLRDKDLE-------MEELMLQDETLLGTMQSYMD 152
::|..| ||....|.:.|...|..|:...|| :.:|.|.....|||.|.|:|
Frog 3 ARWGAG--------EETLTIGGMELFTAGGPLQCNTLEDHEPCSGLSDLSLDAGGFLGTFQGYVD 59
Human 153 ASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELLVSP--REGS 215
.|:||:|:|.|:|.|::...:::||:|||.||||||||||.||:||||:|||:|||||| :|.|
Frog 60 HSIISIIDDTGALAENKGHFDEENELSLLNALTEILDNADDENMSPFDTIPDTELLVSPKDKENS 124
Human 216 SLHKLLTLSRTPPERDLITPVDPLGPSTG--SSRGSGVEMSLPDPSWDFSPPSFLETSSPK---- 274
:..:.|:||||||:| .::|:|......| .|..|| .:|:..|.:. :|:||
Frog 125 TFQRFLSLSRTPPDR-AVSPLDDQRRINGKFDSHTSG-------QNWELFPENI--SSTPKRHNR 179
Human 275 ---LPSWRPPRSRPRWGQSPPPQQRSDGEEEEEVASFSGQILAGELDNCVSSIPDFPMHLACPEE 336
:.:....|.||.. .|||||||:||..:.... .|::..:....:|.::....|.
Frog 180 QRNMRACLTRRLRPEL-----TQQRSDGEDEEVPSPEKN----SEINAALDLEQEFAVNSVNREN 235
Human 337 EDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQPDDLTLPEGCVVLEI 401
|.:..|.....|...:....:|::||:.|||||||: :|:..|..:.:.:| .|.|| :.|||
Frog 236 EFEEDAFVKRTPCIINTENVALNDLVKYMHPYCLPS---VAACMDPKESEVED-NLNEG-IFLEI 295
Human 402 VGQAATAGDDLEIPVVV---RQVSPG--------------------------------------- 424
|.. |..:::|||: .::|.|
Frog 296 VAN----GKCIKLPVVIEPAEEMSEGLEERIYLSGENNSDVEMQESSEEQCRSLQDSDQHLVKTT 356
Human 425 -------PRPVLLDDSLETSSALQLLM-----PTLE---SETEAAVPKVTLCSEKEGLS------ 468
..|:||| .:..|.:|. |||| ::|.|..|.....|...|||
Frog 357 DECTQLLQEPILLD----CNKMLPVLSSQEEEPTLEPQQNDTVAKEPIFEPTSVDNGLSETIFKQ 417
Human 469 ---LNSEEKLDSACLLKPREV-----VEP-----------VVPKEPQNPPANAAPGSQRARKGRK 514
.|:|....: |:|.|. ::| ||.|..::...| .||:::...|
Frog 418 CNDFNTESDNQN---LEPAESGPVKDIDPESCLQDTCKERVVQKGKKSDKTN---HSQKSKGKMK 476
Human 515 KKSKE---------------QPAACVEGYARRLRSSSRGQSTVGTE---VTSQVDNLQKQPQEEL 561
||:.| ||..|: .:.|..| :..|::.::::.|.||
Frog 477 KKTTECKQQDVVERMTLQNNQPPVCL-------------SNPVVQESDFLIKQLEQVKRETQMEL 528
Human 562 QKESGPLQGKGKPRA---WARAWAAALENSSPKNLERS-AGQSSPAKEGPLDLYPKLADT----I 618
:.|..::.|.:.|. .:.|....:.|...|.:|:| |.::...|.. .:.||| :
Frog 529 -RSSKLVRAKARTRLTIDTSSAPVKKIHNEKTKKIEKSLAIENEKTKRS-----SENADTEKCLV 587
Human 619 QTNPIPTHLSLVDSAQASPMPVDSVEADPTAVGPVLAGPVPVDPGLVDLASTSSELVEPLPAEPV 683
|.|. .||.:.|: |.|:||.| .:.|
Frog 588 QNNV----KSLCEQAE----------------------------------SKSAELAE---GDTV 611
Human 684 LINPVLADSAAVDPAVVPISDNLPPVDAVPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDPRR 748
| |...|.|......|.:|.|
Frog 612 L------DDKHVHPQEAESKDYIPNV--------------------------------------- 631
Human 749 GAVSSALGGSAPQLLVESESLDPPKTIIPEVKEVVDSLKIESGTSATTHEARPRPLSLSEYRRRR 813
|| .|||:...|:..:::...::::: :.||:|:.|||||||.|.
Frog 632 ------------QL---KESLNDKGTVKGDIENDANAVQM-------SKEAKPKSLSLSEYRMRM 674
Human 814 QQRQAETEERSPQPPT-GKWPSLPETPTGLADIPCLVIPPAPAKKTALQRSPETPLEICLVPVGP 877
|||:..|.:|..:..: .||||:||.||.||:|||||: |.|:. |||.|
Frog 675 QQRKGNTVQRDNESTSESKWPSIPEPPTELAEIPCLVV---PGKEE--------------VPVKP 722
Human 878 SPASPSPEPPVSKPVASSPTE-QVPSQEMPLLARPS----PPVQSVSPAVPTPPSMSAALPFPAG 937
|.|.|..|.......|..|:. :..|..:..|::.| |..:::.|..|...:.:....|..
Frog 723 SKAKPLEEKSCDISRAEEPSGLENSSNLVSALSKASVQSVPTAETLQPKQPDVLTQTIDATFSV- 786
Human 938 GLGMPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGT 1002
..||:||||. :| |:||..| :.|..||.:||||.||...|.
Frog 787 ---TQPSVPPPPF----------------YT-----PTWPSVP-LQPPYYPSIPPPPAVPFPRGG 826
Human 1003 P----GAYAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQ-HAPFWST-VPPPPL-----P 1056
| ....:||...:.|.|.|.| |...||.|. ..|.|.. :||||| |
Frog 827 PHDPLHTLPMPPPPVISWPPFPPP-----------PFAMGPNPSPELPLWGAGIPPPPLPFWPHP 880
Human 1057 PASIGRAVPQPKMESRGTP----------AGPPENVLPLS------------------------- 1086
|...|....|..:..||.| |.||.:.:.|:
Frog 881 PVQQGLHGVQQGLPGRGPPLLSTDGTTGGAMPPVSSIELNKNTDSHMSKETYVASNKHCSQNIST 945
Human 1087 ----MAPPL-------------SLGLPGHGAPQTEPTKVEVKP---------------------- 1112
...|| :..||.|....|..|||.:|.
Frog 946 ESSKKTSPLQKCSNSLVSKDRNASDLPKHPRELTNQTKVPLKKSENRSTKLSAQLHSDLRKSDLP 1010
Human 1113 ------------VPASPHPKH--------------KVSALVQ---------SPQM-------KAL 1135
|||.|...: |:..::: :||. |:.
Frog 1011 KHARSVEKTPENVPAEPKKANLLDPNLKSANPVVLKIMEILKKAQKLGFQINPQQPLESGSAKSG 1075
Human 1136 ACVSAEGVTVEEPAS--ERLKP----------------ETQETRP-----REKPPLPATKAVPTP 1177
.|:|:..:.:..|.. :..|| |:..|.| |.|..|.....|...
Frog 1076 TCLSSPKLAISVPLQPVQNQKPGVPCKEQVNVNTSTLKESLSTDPVLEKQRAKETLNVASEVQKQ 1140
Human 1178 RQSTVPKLPAVHPARL--RKLSFLPTPRTQGSEDVVQAFIS-----------EIGIEASDLSSLL 1229
..:...:.|.:..|:: .|::.|...|...:..:..|..: |.||||:||:|||
Frog 1141 ETAESSQAPNIQLAQMPVSKVATLGDSRADLNIKIPSAVANDGQTTGENSSCEEGIEATDLTSLL 1205
Human 1230 EQFEKSEA-KKECPPPAPADSLAVGNSGGVDIPQEKRPLDRLQAPELANVAGLTPPATPPHQLWK 1293
|||||||| .:|....:|...:||||| |::.|.||:.||||.||||||.||||||||||||:||
Frog 1206 EQFEKSEANNEEQHTQSPELKVAVGNS-GLERPVEKKVLDRLLAPELANTAGLTPPATPPHQMWK 1269
Human 1294 PLAAVSLLAKAKSPKSTAQE----GTLKPEGVTEAKHPAAVRLQE------GVHGPSRVHVGSGD 1348
|..|.||..|||......|: ..||...:.|||.....:|:. .|:....:||.|||
Frog 1270 PAIASSLTGKAKPLHGNFQDRACASPLKAAKLIEAKPLPQSKLRNKSTAIPPVYAQPPIHVASGD 1334
Human 1349 HDYCV--RSRTP----PKKMPALVIP------EVGSRWNVKRHQDITIKPVLSL----------G 1391
||||: .|:.| ....|..|.. |.|||||||.||:|||||::.. .
Frog 1335 HDYCILATSKCPVAASSSSNPETVATTQNTHCEEGSRWNVKHHQNITIKPIVPFNKRGQNKTCQN 1399
Human 1392 PAAPP---------PPCIA------------ASREPLDHRTSS-EQADPSAPCLAPSSLLSPEAS 1434
.|..| .||.. .:.:||||||:. |......| .|.|:||:||
Frog 1400 QATTPQLADVCNRSTPCGTNKFVPSISNIQNDTNDPLDHRTNKVEDVAGKHP---GSVLMSPDAS 1461
Human 1435 PCRN-DMNTRTP---PEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSSGSNRTSEASS 1495
||.: |..|||. .:.|..:|::||||:...|.||.. |||| |:..:.|
Frog 1462 PCHSEDWETRTSVRREDTSVSRRALRCYRRYRSSPSPQK--------------SSGS-RSCSSDS 1511
Human 1496 SSSSSSSSSRSRSRSLSPPHKRWR----RSSCSSSGRSRRCSSSSSSSSSSSSSSS-----SSSS 1551
|.|||||||||| |||.||.| |....||.|||...|||.|.|||||.|| |||.
Frog 1512 SCSSSSSSSRSR----SPPSKRRRISRSRHRSRSSSRSRYHGSSSRSWSSSSSCSSRSCSPSSSC 1572
Human 1552 SRSRSRSPSPRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRF 1616
||||||||..||...|.||..|..|.: ||::|.|||||||||||:||||..||||||||.||
Frog 1573 SRSRSRSPYRRRYRSRSRRCESQESSN---RQKILHKERAIEERRVVYIGKINSRMTRSELKSRF 1634
Human 1617 SVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYS 1681
|.||||||||||||.:|||||||||||..|||||||:|||||..||.||||||||||||||.||:
Frog 1635 SAFGEIEECTIHFREEGDNYGFVTYRYTCEAFAAIENGHKLRLPDELPFDLCFGGRRQFCKSSYA 1699
Human 1682 DLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR 1717
|||||::|||||||:|:|:|||||||||||||.:||
Frog 1700 DLDSNKDDFDPAPVRSRFESLDFDTLLKQAQKGIRR 1735
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