Protein Alignment PPRC1 and pprc1

DIOPT Version :10

• Sequence 1: XP_024303683.2
• Gene: PPRC1 / 23082
• HGNCID: 30025
• Length: 1717
• Species: Homo sapiens
• Sequence 2: XP_001338236.3
• Gene: pprc1 / 100002463
• ZFINID: ZDB-GENE-030131-9858
• Length: 1220
• Species: Danio rerio
• Alignment Length: 1681
• Identity: 496/1681 - (29%)
• Similarity: 664/1681 - (39%)
• Gaps: 616/1681 - (36%)

Human   144 LGTMQSYMDASLISLIEDFGSLGESRLSLEDQNEVSLLTALTEILDNADSENLSPFDSIPDSELL 208
            |..:...:|.|::|:.|| ...||.:.:|::::|.:|||||||||||.|.|||||||::|||:|.
Zfish    49 LEALHGCLDPSILSIFED-SPTGEVKSNLDEESEATLLTALTEILDNVDDENLSPFDTLPDSDLF 112

Human   209 VSPR--EGSSLHKLLTLSRTPPERDLITPVDPLGPSTGSSRGSGVEMSLPDPSWDFSPPSFLETS 271
            ...:  |.|.|.||.|.|                                      :|.|.:.|.
Zfish   113 SGHKGQEHSPLRKLFTRS--------------------------------------TPESVIHTR 139

Human   272 SPKLPSWRPPRSRPRWGQSPPPQQRSDGEEEEE-VASFSGQILAGELDNCVSSIPDFPMHLACPE 335
            .      .|.:|.||..:.  .||.|:|||||: .||||  |....:|  :.|:..|...|....
Zfish   140 Q------FPGKSLPRMQRL--SQQNSEGEEEEDGDASFS--IPLSNID--LLSLDGFDWCLPVSL 192

Human   336 EEDKATAAEMAVPAAGDESISSLSELVRAMHPYCLPNLTHLASLEDELQEQPDDLTLPEGCVVLE 400
            |:|            |:....||.|||:.|||||:.    |....:|.||.    .|||..:|||
Zfish   193 EQD------------GESMPVSLGELVKHMHPYCMT----LCVEGEEGQEH----LLPERGLVLE 237

Human   401 IV-----GQAATAGDDLEIPVVVRQVSPGPRPVLLDDSLETSSALQLLMPTLESETEAAVPKVTL 460
            :|     |:...|..||.||  :.|..|                         :|.|..||
Zfish   238 VVDQGEHGEPILAIPDLSIP--LSQADP-------------------------TECEQRVP---- 271

Human   461 CSEKEGLSLNSEEKLDSACLLKPREVVEPVVPKEPQN-----PPANAAPGSQRARKGR----KKK 516
                 |.|::.:|                  ||...:     .|:|.:|..:....|:    ||:
Zfish   272 -----GNSIDKQE------------------PKHDNHAQKVTSPSNVSPVEKEKEVGKVCKGKKR 313

Human   517 SKEQPAACVEGYARRLRSSSRGQSTVGTEVTSQVDNLQKQPQEELQKESGPLQGKGKPRAWARAW 581
            .|......||  .|.||||...:..            ||:||:|.:|:.              .:
Zfish   314 CKSVETPLVE--QRILRSSKVNEEP------------QKKPQKEQKKKV--------------TF 350

Human   582 AAALENSSPKNLERSAGQSSPAKEGPLDLYPKLADTIQTNPIPTHLSLVDSAQASPMPVDSVEAD 646
            :.:|.::.|              |.| .|||           ||         ..|.|.|..|..
Zfish   351 SPSLTSAEP--------------ERP-KLYP-----------PT---------KEPEPRDEEEQT 380

Human   647 PTAVGPVLAGPVPVDPGLVDLASTSSELVEPLPAEPVLINPVLADSAAVDPAVVPISDNLPPVDA 711
            .|:         ..:..:.:|.:.::.|.:|...|                        ||....
Zfish   381 MTS---------KAETKITNLTTDNNSLEKPGEEE------------------------LPSKQE 412

Human   712 VPSGPAPVDLALVDPVPNDLTPVDPVLVKSRPTDPRRGAVSSALGGSAPQLLVESESLDPPKTII 776
            .||                          .:|:|.:|
Zfish   413 TPS--------------------------EQPSDCQR---------------------------- 423

Human   777 PEVKEVVDSLKIESGTSATTHEARPRPLSLSEYRRRRQQRQAETEERSPQPPTGKWPSLPETPTG 841
                                :|.:|:||||.:||..|||::.:..:::....| |||:|||.|..
Zfish   424 --------------------NETKPKPLSLQQYRLLRQQKKPDPVDKTEDYST-KWPTLPEAPKE 467

Human   842 LADIPCLVIP----PAPAKKTALQRSPETPLEICLVPVGPSPASPSPE----PPVS------KPV 892
            |..||||..|    |.......:::.|...:.....|.||: |.|:||    ||.|      |||
Zfish   468 LPPIPCLPDPSLRDPRKTSHIPVKKDPVPEIMPAWHPRGPA-APPTPEALLVPPASLMGSSRKPV 531

Human   893 A--------------SSPTEQ---VPSQEMPLLARPSPPVQSVSPAVPTPPSMSAALPFPAGGLG 940
            :              |||.:|   :..|:..:....|...::||..|.|.|..|.:|.
Zfish   532 SSKSTSSDCSSQSVHSSPQKQPAPIAVQQNTIHTETSSLERTVSQPVSTTPGGSTSLK------- 589

Human   941 MPPSLPPPPLQPPSLPLSMGPVLPDPFTHYAPLPSWPCYPHVSPSGYPCLPPPPTVPLVSGTPGA 1005
                                                      :||...||...|.        .|
Zfish   590 ------------------------------------------TPSQEECLHRNPN--------AA 604

Human  1006 YAVPPTCSVPWAPPPAPVSPYSSTCTYGPLGWGPGPQHAPFWSTVPPPPLPPASIGRAVPQ---- 1066
            :||        ||...|:.|...|            .|....:|..|.|...|...|...|
Zfish   605 HAV--------APSKVPLEPQMIT------------THVQSSTTSAPKPCAAAPAKRETEQVVLA 649

Human  1067 PKMESRGTPAGPPENVLPLSMAPPLSLGLPGHGAPQTEPTKVEVKPVPASPHPKHKVSALVQSPQ 1131
            |..|...|.                   ||.:....|..::..|.|:.|.|....:|.|.|
Zfish   650 PVCEQAKTT-------------------LPTNSKKLTSRSQPHVAPIAAQPFFTAQVQARV---- 691

Human  1132 MKALACVSAEGVTVEEPASERLKPETQETRPREKPPLPATKAVPTPRQSTVPKLPAVHPARLRKL 1196
                         ||  .:|:::..:.||              |.|:.:||
Zfish   692 -------------VE--LAEQMRMASSET--------------PKPKTATV-------------- 713

Human  1197 SFLPTPRTQGSEDVVQAFISEIGIEASDLSSLLEQFEKSEAKKEC-PPPAPADSLAVGNSGGVDI 1260
                        :::::|.|||||||:||:|||||||:|:.|:|. .|.....:.|||||....:
Zfish   714 ------------ELIESFTSEIGIEAADLTSLLEQFEESQPKEETRVPEVCGRAAAVGNSSFEQV 766

Human  1261 PQEKRPLDRLQAPELANVAGLTPPATPPHQLWKPLAAVSLLAKAKS---PKSTAQEG-------- 1314
              |.:.:::.:..:|.:.||||||||||||:|||:|.||||.|.|.   ||||..:.
Zfish   767 --ETKAVEKTRNHDLGSTAGLTPPATPPHQMWKPIAPVSLLGKTKKSEVPKSTTNKAIQIEARPL 829

Human  1315 -----TLKPEGVTEAKHPAAVRLQEGVHGPSRVHVGSGDHDYCVRSRTPPKKMPALVIPEVGSRW 1374
                 ..||:.:|.........|               |||||:    |||::..   .||||||
Zfish   830 PSNKLRCKPQTLTTTGQTQPFSL---------------DHDYCL----PPKELSQ---TEVGSRW 872

Human  1375 NVKRHQDITIKPVLSLGPAAPPPPCIAASREPLD---HRTSS---------------EQADPSAP 1421
            |||:...|.||.|     ..|       |.:||.   .:|||               .|......
Zfish   873 NVKQQPSIVIKTV-----ELP-------SNKPLQKNVSKTSSSTSSVTEETQKNLSLSQPSEGTS 925

Human  1422 CLAPSSLL-SPEASPCRNDMNTRTPPEPSAKQRSMRCYRKACRSASPSSQGWQGRRGRNSRSVSS 1485
            |...||:| :|:|||.|.|..:....|.:        ::|:...:..||..:|..|||..|..
Zfish   926 CTLNSSVLETPDASPNRPDSESSLLNEVN--------HKKSVDYSKCSSTKYQQDRGRQKRRY-- 980

Human  1486 GSNRTSEASSSSSSSSSSSRSRSRSLSPPHKRW--RRSSCSSSGRSRRCSSSSSSS-------SS 1541
               |....|||.|||.||||||    |||.||:  |.||..||..||..|||.|.|       |.
Zfish   981 ---RAPSTSSSESSSESSSRSR----SPPRKRYRSRHSSSRSSSSSRSRSSSRSFSPPRRRRYSY 1038

Human  1542 SSSSSSSSSSSRSRSRSPS----------PRRRSDRRRRYSSYRSHDHYQRQRVLQKERAIEERR 1596
            |||.|.|.|.|||||||.|          .||..|:|..|...::.....::|   ||:||||||
Zfish  1039 SSSRSGSWSCSRSRSRSRSTDSHEHRHWRSRRSPDQRPGYHHVQNSSEDTKRR---KEKAIEERR 1100

Human  1597 VVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTYRYAEEAFAAIESGHKLRQAD 1661
            ||::|:|.|.|||.|||:||..||:|||||:|||..|||||||||...::||.|||:|..||:.:
Zfish  1101 VVYVGRICGNMTRMELKERFLYFGDIEECTVHFRENGDNYGFVTYYSVKDAFNAIENGSILRKPN 1165

Human  1662 EQPFDLCFGGRRQFCKRSYSDLDSNREDFDPAPVKSKFDSLDFDTLLKQAQKNLRR 1717
            |.||||||||||||||.||:||||||| :||.|.|.|||:||||||||||||||:|
Zfish  1166 ELPFDLCFGGRRQFCKASYADLDSNRE-YDPKPTKGKFDALDFDTLLKQAQKNLKR 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPRC1	XP_024303683.2	PHA03247	<663..1255	CDD:223021	130/627 (21%)
		RRM_PRC	1594..1684	CDD:410035	61/89 (69%)
pprc1	XP_001338236.3	Atrophin-1	<414..>629	CDD:460830	72/367 (20%)
		RRM_SF	1098..1188	CDD:473069	61/89 (69%)