| Sequence 1: | NP_002006.2 | Gene: | FOXO1 / 2308 | HGNCID: | 3819 | Length: | 655 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_012135.1 | Gene: | FKH1 / 854675 | SGDID: | S000001393 | Length: | 484 | Species: | Saccharomyces cerevisiae |
| Alignment Length: | 191 | Identity: | 55/191 - (28%) |
|---|---|---|---|
| Similarity: | 82/191 - (42%) | Gaps: | 58/191 - (30%) |
- Green bases have known domain annotations that are detailed below.
|
Human 148 QPRKSSSSRRNAW--GNL---------------------SYADLITKAIESSAEKRLTLSQIYEW 189
Human 190 MVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG--TGKSSWWMLNPE---------- 242
Human 243 GGKSGKSPRRRAASMDNN-----SKFA-----KSRS------RAAKKKASLQSGQEGAGDS 287 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FOXO1 | NP_002006.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..63 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 116..158 | 3/9 (33%) | |||
| FH_FOXO1 | 151..249 | CDD:410834 | 36/132 (27%) | ||
| DNA-binding. /evidence=ECO:0000269|PubMed:18786403 | 211..218 | 5/6 (83%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 234..344 | 22/80 (28%) | |||
| DNA-binding. /evidence=ECO:0000269|PubMed:18786403 | 234..237 | 0/2 (0%) | |||
| Nuclear localization signal | 251..253 | 0/1 (0%) | |||
| Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 | 283..563 | 2/5 (40%) | |||
| Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 | 363..459 | ||||
| FOXO_KIX_bdg | 423..504 | CDD:465228 | |||
| Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 | 462..466 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 507..537 | ||||
| FOXO-TAD | 597..633 | CDD:435506 | |||
| FKH1 | NP_012135.1 | COG5025 | 1..484 | CDD:227358 | 55/191 (29%) |
| Blue background indicates that the domain is not in the aligned region. | |||||