Protein Alignment FOXO1 and Foxo1

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_001178775.1
• Gene: Foxo1 / 84482
• RGDID: 620283
• Length: 649
• Species: Rattus norvegicus
• Alignment Length: 655
• Identity: 603/655 - (92%)
• Similarity: 623/655 - (95%)
• Gaps: 6/655 - (0%)

Human     1 MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAA 65
            |||||||||.|||||||||.||||||||||||:||||.|||||||||.||||||.|.|  |||:|
  Rat     1 MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGSTAANPDATASL--ASASA 63

Human    66 VSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGP 130
            ||.|||||||||||||||.:|||    .||.||||||:.|||||||||||||:|.|||||||.||
  Rat    64 VSTDFMSNLSLLEESEDFARAPG----CVAVAAAAAASRGLCGDFQGPEAGCVHSAPPQPPPTGP 124

Human   131 LSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVP 195
            |||.|||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   125 LSQPPPVPPAAAGPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVP 189

Human   196 YFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   190 YFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNN 254

Human   261 SKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTIS 325
            |||||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
  Rat   255 SKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTIS 319

Human   326 GRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVS 390
            ||||||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||||||
  Rat   320 GRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVS 384

Human   391 TQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQY 455
            ||||||:||||||||||||||||||||||||.|||||||||||:||||:|||||:||||||::||
  Rat   385 TQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYAKYTYGQSSMSPVPQMPMQTLQDSKSSYGGLNQY 449

Human   456 NCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPS 520
            ||||||||||||||||||||||:||||||||||||||||||:|||||||..|||||.||||||||
  Rat   450 NCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVLMGPNSVMPAYGSQAPHNKMMNPS 514

Human   521 SHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCN 585
            ||||||||||||:||||.|||.|:||||||.|||||.||||:||||.|||||||||.||||||||
  Rat   515 SHTHPGHAQQTSSVNGRALPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGNYSSVSSCN 579

Human   586 GYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTH 650
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   580 GYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTH 644

Human   651 SWVSG 655
            |||||
  Rat   645 SWVSG 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		52/61 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		36/41 (88%)
		FH_FOXO1	151..249	CDD:410834	96/97 (99%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		106/109 (97%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		2/2 (100%)
		Nuclear localization signal	251..253		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		258/279 (92%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		88/95 (93%)
		FOXO_KIX_bdg	423..504	CDD:465228	73/80 (91%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537		27/29 (93%)
		FOXO-TAD	597..633	CDD:435506	35/35 (100%)
Foxo1	NP_001178775.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		53/62 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..151		33/38 (87%)
		FH_FOXO1	145..243	CDD:410834	96/97 (99%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	205..212		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..339		107/110 (97%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	228..231		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250	245..247		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	277..557		258/279 (92%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	357..453		88/95 (93%)
		FOXO_KIX_bdg	417..498	CDD:465228	73/80 (91%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	456..460		3/3 (100%)
		FOXO-TAD	591..627	CDD:435506	35/35 (100%)