DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and foxo1a

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_001070725.2 Gene:foxo1a / 768121 ZFINID:ZDB-GENE-061013-59 Length:652 Species:Danio rerio


Alignment Length:711 Identity:404/711 - (56%)
Similarity:466/711 - (65%) Gaps:115/711 - (16%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAEAP--QVVEIDPDFEPLPRPRSCTWPLPRPEF---SQSNSATSSPAPSGSAAANPDAAAGLPS 60
            ||:|.  |:||||||||||.||||||||||||||   :.::|.|||||||....         ||
Zfish     1 MADAAQNQMVEIDPDFEPLSRPRSCTWPLPRPEFPNPAAADSNTSSPAPSVKQE---------PS 56

Human    61 ASAAAVSADFMSNLSLLEESEDFP-QAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQ 124
            :     :|||::|||||||:||:| |.|..                ||.:||..| .|:|    |
Zfish    57 S-----TADFINNLSLLEENEDYPDQKPLM----------------LCSEFQCQE-NCIH----Q 95

Human   125 PPPPGPLSQHP----PVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQ 185
            ...|....|.|    ||..|||...|.| |||||||||||||:|||||||||||||.||||||||
Zfish    96 QQIPSQQQQVPVLSSPVAAAAAAAAAAQ-RKSSSSRRNAWGNMSYADLITKAIESSPEKRLTLSQ 159

Human   186 IYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSP 250
            ||:|||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||
Zfish   160 IYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFIRVQNEGTGKSSWWMLNPEGGKSGKSP 224

Human   251 RRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRP 315
            |||||||||||||||||.||||||.:||.|.||..||||||:.|||.||.|||||||:.|:.|||
Zfish   225 RRRAASMDNNSKFAKSRGRAAKKKLALQGGPEGGADSPGSQYGKWPGSPNSHSNDDFEAWTAFRP 289

Human   316 RTSSNASTISGRLSPIMTEQDDLGEGDVHSMVY--PPSAAKMASTLPSLSEI------SNPEN-M 371
            ||||||||:||||||.:  .|:||:.||| |||  |.|..||.||||||||:      |..|| |
Zfish   290 RTSSNASTLSGRLSPFI--DDELGDSDVH-MVYPGPGSGTKMTSTLPSLSEMAGSLGHSGSENVM 351

Human   372 ENLLDNLNLLSSPTSLT-----VSTQSSPGTMMQQTPCYS-FAPPNTSLNS--PSPNYQKYTYGQ 428
            |||||||||||.....|     .|.||||.::||.:|.|| ::.|..|..|  ...:::|..|||
Zfish   352 ENLLDNLNLLSPKNPSTGGPGSGSNQSSPSSLMQASPGYSPYSSPGLSAVSQQTQQDFRKCLYGQ 416

Human   429 SSMSPLPQMPIQTLQDNKSSY----GGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNS 489
            :.|..:..||:|.|.::|.|:    |.|.|:||..||||||||||..| .|:|..||..|:|...
Zfish   417 AGMGSMSPMPMQPLPESKPSFGPGGGTMGQFNCTAGLLKELLTSDGEP-GDLMPSVDTVVSQSAG 480

Human   490 RVLGQNVMMGPNSVMSTYGSQASHNKMM--NPS-SHT--HP----GHAQQTS-AVNGRPLPHTVS 544
               |...|:.|.|        :..|::|  .|: |||  ||    |.|..|| |:|||.| |.::
Zfish   481 ---GSGCMLPPYS--------SGRNELMGGGPTHSHTLSHPHNMHGQAPPTSVALNGRSL-HPLT 533

Human   545 TMPHTSGMNRLTQVKTPVQVPLPHPMQMSA---LGG----YSSVSSCNGYGR-------MGLLHQ 595
            .:.|:|...||...|:|:|      ||...   |||    |.|:|| |||||       ..|.|.
Zfish   534 AIGHSSVGGRLGSGKSPMQ------MQYGGSGHLGGGLPPYCSMSS-NGYGRGPGMMAHQQLQHL 591

Human   596 EKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSF-PHSVKTTTHSWVSG 655
            ||||||||||.|||.:||:|||:.:.||||::||||||.:...|.| ||||||||||||||
Zfish   592 EKLPSDLDGMPIERFECDVESILHDTLMDGESLDFNFDPMNSQQGFVPHSVKTTTHSWVSG 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 38/66 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 20/45 (44%)
FH_FOXO1 151..249 CDD:410834 93/97 (96%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 85/109 (78%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 2/2 (100%)
Nuclear localization signal 251..253 1/1 (100%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 148/310 (48%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 47/114 (41%)
FOXO_KIX_bdg 423..504 CDD:465228 37/84 (44%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 14/39 (36%)
FOXO-TAD 597..633 CDD:435506 25/35 (71%)
foxo1aNP_001070725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57 37/64 (58%)
FH_FOXO1 125..223 CDD:410834 93/97 (96%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..277 57/68 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..406 18/46 (39%)
FOXO_KIX_bdg 411..497 CDD:465228 38/97 (39%)
FOXO-TAD 593..631 CDD:435506 27/37 (73%)

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