Protein Alignment FOXO1 and Foxo1

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Alignment Length: 658
• Identity: 607/658 - (92%)
• Similarity: 626/658 - (95%)
• Gaps: 9/658 - (1%)

Human     1 MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAA 65
            |||||||||.|||||||||.||||||||||||:||||.||||||||.|||||||||.|  |||:|
Mouse     1 MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAAANPDAAASL--ASASA 63

Human    66 VSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGP 130
            ||.|||||||||||||||.:|||    .||.||||||:.|||||||||||||:|||||||||.||
Mouse    64 VSTDFMSNLSLLEESEDFARAPG----CVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPPPTGP 124

Human   131 LSQHPPVPP---AAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVK 192
            |||.|||||   ||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   125 LSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVK 189

Human   193 SVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASM 257
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   190 SVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASM 254

Human   258 DNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNAS 322
            ||||||||||.|||||||||||||||.||||||||||||||||||||||||||||||||||||||
Mouse   255 DNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNAS 319

Human   323 TISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSL 387
            |||||||||||||||||:|||||:|||||||||||||||||||||||||||||||||||||||||
Mouse   320 TISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSL 384

Human   388 TVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGM 452
            |||||||||:||||||||||||||||||||||||.||||||||||||||||:|||||:||||||:
Mouse   385 TVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGL 449

Human   453 SQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMM 517
            :||||||||||||||||||||||||:||||||||||||||||||||||||||..|||||||||||
Mouse   450 NQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMM 514

Human   518 NPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVS 582
            ||||||||||||||::||||.|||.|:||||||.|||||.||||:||||.|||||||||.|||||
Mouse   515 NPSSHTHPGHAQQTASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGSYSSVS 579

Human   583 SCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKT 647
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   580 SCNGYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKT 644

Human   648 TTHSWVSG 655
            ||||||||
Mouse   645 TTHSWVSG 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		53/61 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		37/44 (84%)
		FH_FOXO1	151..249	CDD:410834	96/97 (99%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		106/109 (97%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		2/2 (100%)
		Nuclear localization signal	251..253		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		260/279 (93%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		89/95 (94%)
		FOXO_KIX_bdg	423..504	CDD:465228	75/80 (94%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537		27/29 (93%)
		FOXO-TAD	597..633	CDD:435506	35/35 (100%)
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		54/62 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		34/41 (83%)
		FH_FOXO1	148..246	CDD:410834	96/97 (99%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		107/110 (97%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		261/281 (93%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		89/95 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		25/26 (96%)
		FOXO_KIX_bdg	420..501	CDD:465228	75/80 (94%)
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463		3/3 (100%)
		FOXO-TAD	594..630	CDD:435506	35/35 (100%)