Protein Alignment FOXO1 and fd102C

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_651951.1
• Gene: fd102C / 43843
• FlyBaseID: FBgn0039937
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 136/674 - (20%)
• Similarity: 221/674 - (32%)
• Gaps: 280/674 - (41%)

Human    17 LPRPR-SCTWPLPRPEFSQSNSATSS-----------------------PAPSGSAAANP----- 52
            :|:|. ...:||.....||:.|.|.:                       ....||.|:.|
  Fly    27 VPKPSLPNIYPLGTTRTSQAQSTTMTLEQYRLQLYNYALNIERLRCPQYGGTGGSGASAPWLHLS 91

Human    53 ----DAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGP 113
                ..:..|||.:..|.    :|.:||      |||....                    ||
  Fly    92 PYGHHGSGSLPSVNRMAA----LSTISL------FPQTQRI--------------------FQ-- 124

Human   114 EAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAE 178
                     |:.|.|    ||                             ||..||..||.||.:
  Fly   125 ---------PEEPKP----QH-----------------------------SYIGLIAMAILSSTD 147

Human   179 KRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNP-- 241
            .:|.||.||::::.:.|||:.:|     .||:|||||||||:..||:......||..:|.::|
  Fly   148 MKLVLSDIYQYILDNYPYFRSRG-----PGWRNSIRHNLSLNDCFIKSGRSANGKGHYWAIHPAN 207

Human   242 -EGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPG---------------- 289
             |..:.|...||:|             .|..:|...| |..:.:.|||.
  Fly   208 MEDFRKGDFRRRKA-------------QRKVRKHMGL-SVDDASTDSPSPPPLDLTTPPPPSSQS 258

Human   290 ----------------SQFSKWPASPG-SHSN-------------DDFDNWSTFRPR-------- 316
                            .||....::|| :|.:             ::.|  .|.:|.
  Fly   259 ALQLSALGYPYHQHYIGQFFNRSSAPGMTHYSPPDPALLMQRQEANNLD--QTIQPTQLQQPHSH 321

Human   317 -------TSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENL 374
                   .|:..:||:...|.....|.|:             |:.:|..:..:..:|.
  Fly   322 HQHFAYINSTTTTTIANMFSQTRKRQFDV-------------ASLLAPDVQIVDIVSE------- 366

Human   375 LDNLNLLSSPTSLTVSTQSSPGTMMQQT-----------PCYSF---APPNTSLN------SPSP 419
             |..:.::..||...:||:....:.:||           |....   |..:..:|      |..|
  Fly   367 -DQESSVTPTTSARTTTQTHHTVITKQTIHREVVLGLEKPVQDADIDADIDVEVNVDVVDDSIIP 430

Human   420 NYQKYTYGQ---SSMSPLPQMPIQTLQDNKSSY---GGMSQYNCAPGLLKELLTSDSPPHNDIMT 478
            :...||.|:   .:...|.|  |.:::|| :||   |.:|.::..|         |..|.:|
  Fly   431 DTDSYTDGEDRKKTRGTLKQ--IFSIEDN-NSYLIDGRLSSFDADP---------DHDPDHD--- 480

Human   479 PVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTV 543
            |.|          |.|:.....:|...:.||.:|.:              :::|::...|:...:
  Fly   481 PED----------LEQHNFSIASSAARSLGSSSSQH--------------EESSSLEECPIQECI 521

Human   544 STMPHTSGMNRLTQVKT-PVQVPL 566
             ..|.|:.::.:...|| .:.||:
  Fly   522 -VAPQTALISSMATAKTSTLSVPI 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		15/78 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		5/41 (12%)
		FH_FOXO1	151..249	CDD:410834	36/100 (36%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		28/173 (16%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		62/367 (17%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		25/121 (21%)
		FOXO_KIX_bdg	423..504	CDD:465228	21/86 (24%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537		4/29 (14%)
		FOXO-TAD	597..633	CDD:435506
fd102C	NP_651951.1	FH_FOXQ2-like	129..223	CDD:410809	42/144 (29%)