DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and fd96Cb

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_524496.1 Gene:fd96Cb / 43011 FlyBaseID:FBgn0004898 Length:271 Species:Drosophila melanogaster


Alignment Length:302 Identity:70/302 - (23%)
Similarity:105/302 - (34%) Gaps:95/302 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 228
            ||..|...||..|.::.|.||:||.:::...|:::     .::..|:||:|||||.:..||:|..
  Fly    17 SYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYR-----KNTQKWQNSLRHNLSFNDCFIKVPR 76

Human   229 EGT--GKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQ 291
            ..|  ||.|:|.|:|           .|..|..|....:.|.|...|                 |
  Fly    77 NVTKAGKGSYWTLHP-----------MAFDMFENGSLLRRRKRFRVK-----------------Q 113

Human   292 FSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQ---DDLGEGDV---------- 343
            ..|           |..||   :...::|...::..|...:|:.   |....|.|          
  Fly   114 LEK-----------DISNW---KLAAAANTEMVTHYLDDQLTQMAFADPARHGHVLANASAAQMS 164

Human   344 ----------HSMVYPPSAAKMASTLPSL---------------SEISNPENME------NLLDN 377
                      .::...|:..|.|.|:.||               .|..:|:.:.      ||..|
  Fly   165 PYKATPPILPTTVTQLPARPKRAFTIESLMAPDPASTPNEGLVPMEYGSPDAVALEKPPFNLPFN 229

Human   378 LNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSP 419
            .|.|::...|...:....| .....|||...|| ...|.|.|
  Fly   230 FNELAAQYQLYFPSFFYNG-QYGNIPCYQKTPP-LFHNGPLP 269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158
FH_FOXO1 151..249 CDD:410834 30/86 (35%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 21/132 (16%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 1/2 (50%)
Nuclear localization signal 251..253 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 34/181 (19%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 17/63 (27%)
FOXO_KIX_bdg 423..504 CDD:465228
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537
FOXO-TAD 597..633 CDD:435506
fd96CbNP_524496.1 FH_FOX 1..110 CDD:469596 35/108 (32%)
Blue background indicates that the domain is not in the aligned region.

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