Protein Alignment FOXO1 and jumu

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_524302.1
• Gene: jumu / 41265
• FlyBaseID: FBgn0015396
• Length: 719
• Species: Drosophila melanogaster
• Alignment Length: 446
• Identity: 98/446 - (21%)
• Similarity: 167/446 - (37%)
• Gaps: 155/446 - (34%)

Human    33 SQSNSATSSPAPS---------GSAAANPDAAA-----------GLPSASAAA------------ 65
            ::...|.|||.|:         ||...|....|           ||..|::||
  Fly   242 TELRKAQSSPVPNSLEELGKGKGSTLLNASVGATNTIKLAPGIGGLTFANSAAYQKLKQTSLVKS 306

Human    66 ---VSADFMSNLSLLEESED-----FPQAPGSVAAA-------------------VAAAAAAAAT 103
               :|....||:.|..|..:     ....|.|:|:|                   :::::|::..
  Fly   307 PGGISPGAGSNMGLKREDSNKRGLQASTTPKSIASAANSPHHQMQSNYSLGSPSSLSSSSASSPL 371

Human   104 GGLC-------GDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWG 161
            |.:.       .:..|..:|.:.          ||.|...:||      .|.|....:
  Fly   372 GNVSNLVNIANNNTSGAGSGLVK----------PLQQKVKLPP------VGSPFPKPA------- 413

Human   162 NLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV 226
             .||:.||..|:::|....|.:|:||.::.:..|||:     |:.:|||||:||||||:..|.::
  Fly   414 -YSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFE-----NAPSGWKNSVRHNLSLNKCFEKI 472

Human   227 QNEGTG----KSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKA--------SLQS 279
            :...|.    |...|.:||:          |...||...:....:..||.:.|        ||:.
  Fly   473 ERPATNGNQRKGCRWAMNPD----------RINKMDEEVQKWSRKDPAAIRGAMVYPQHLESLER 527

Human   280 GQ--EGAGDSPGSQFSKWPASPGSHSND----DFDNWSTFRPRTSSNASTISGRLSPIMTEQDDL 338
            |:  .|:.||.....|:   |....|:|    :|::       |..:|.        ::.|:|:.
  Fly   528 GEMKHGSADSDVELDSQ---SEIEESSDLEEHEFED-------TMVDAM--------LVEEEDEE 574

Human   339 GEGDVHSMVYPPSAAK--------MASTL----PSLSEISNPENME--NLLDNLNL 380
            .:||....:.....|:        .|:.|    |.|.:.||..::|  :|.|.:::
  Fly   575 EDGDDDEQIINDFDAEDERHANGNQANNLPINHPLLGQKSNDFDIEVGDLYDAIDI 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		8/41 (20%)
		FH_FOXO1	151..249	CDD:410834	31/101 (31%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		26/123 (21%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		24/116 (21%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		5/20 (25%)
		FOXO_KIX_bdg	423..504	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506
jumu	NP_524302.1	COG5025	<254..>523	CDD:227358	66/307 (21%)
		FH_FOXN1-like	411..491	CDD:410804	29/92 (32%)