Protein Alignment FOXO1 and bin

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 131/583 - (22%)
• Similarity: 201/583 - (34%)
• Gaps: 200/583 - (34%)

Human    55 AAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLH 119
            |.|:|..:.::.|:   |....|..||..|.:...:...| :.:|...|||
  Fly   242 AHGMPVLNYSSSSS---SPAKSLNGSESSPPSQNHLENKV-SGSAVVGTGG-------------- 288

Human   120 PAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLS 184
             :..|..|..|                 ...|.|.:||.....|||.::|..||:.|...:||||
  Fly   289 -SSQQDAPSTP-----------------DTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLS 335

Human   185 QIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV-QNEGT---GKSSWWMLN----- 240
            :||.::.||..:|:     ....|||||:||||||:..|.:: :..|.   ||.::|.::
  Fly   336 EIYAYLQKSYEFFR-----GPYVGWKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTIDENSAH 395

Human   241 -----------PEGGKSGKSPRRRA-------------ASMDNNSKFAKSRSRAAKKKASLQSGQ 281
                       |.|.:|....:..|             |.|||.:.:|.....:....|   :|.
  Fly   396 LFEDEGSLRRRPRGYRSKIKVKPYAGHANGYYASGYGDAGMDNGNYYASPAFASYDYSA---AGA 457

Human   282 EGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPI--MTEQDDLGE-GDV 343
            .|...:.|..|:              |.|:.....:.|::..:...:.|:  .|....|.. |:|
  Fly   458 TGVSPAGGQGFA--------------DPWNAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNV 508

Human   344 H-SMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSF 407
            : |...||.|.......||.|..|:|      |.....|.|..:.|.|..::.         ||:
  Fly   509 NGSATTPPLAHSALGMAPSASSSSSP------LGAAATLQSDYAPTASLVAAG---------YSY 558

Human   408 APPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPP 472
            |....||::          |..|:| |.|:|            |:|                |..
  Fly   559 ATSAGSLDN----------GLRSIS-LQQLP------------GLS----------------SIQ 584

Human   473 HNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGR 537
            |           ||..::                  :||.|:...:.:|  ||.|:.|     |.
  Fly   585 H-----------AQAQAQ------------------AQAHHHHHQHHAS--HPSHSHQ-----GH 613

Human   538 PLPH----TVSTMPHTS------GMNRLTQVKTPVQVP--LPHPMQMSALGG---YSSVSSCN 585
            ...|    |.||.|..|      |::.....:.|..:|  .|.||.::..||   |..:...|
  Fly   614 GSMHQNHGTSSTTPPPSQSGGSHGIDHSPIDRKPAYLPPISPPPMMVALNGGGGYYEGLKYAN 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		6/41 (15%)
		FH_FOXO1	151..249	CDD:410834	39/117 (33%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		22/141 (16%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		59/293 (20%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		21/95 (22%)
		FOXO_KIX_bdg	423..504	CDD:465228	12/80 (15%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537		8/29 (28%)
		FOXO-TAD	597..633	CDD:435506
bin	NP_523950.2	FH_FOX	312..391	CDD:469596	32/83 (39%)