Protein Alignment FOXO1 and slp1

DIOPT Version :10

• Sequence 1: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_476730.1
• Gene: slp1 / 33607
• FlyBaseID: FBgn0003430
• Length: 322
• Species: Drosophila melanogaster
• Alignment Length: 247
• Identity: 68/247 - (27%)
• Similarity: 108/247 - (43%)
• Gaps: 68/247 - (27%)

Human    77 LEESEDFPQAPGSVAAAVAAAAAAAATGG---LCGDF-----------QGPEAGCLHPAPPQPPP 127
            |..|||| .:|...:..:::||.:.::..   |..:|           |..|.|  :|:..|...
  Fly    52 LSASEDF-DSPSRTSTPMSSAAESLSSQNNDKLDVEFDDELEDQLDEDQESEDG--NPSKKQKMT 113

Human   128 PGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVK 192
            .|..::.||                          .||..||..||:.|.|:||||:.||::::.
  Fly   114 AGSDTKKPP--------------------------YSYNALIMMAIQDSPEQRLTLNGIYQYLIN 152

Human   193 SVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN--EGTGKSSWWMLNPE------GGKSGKS 249
            ..||||     .:..||:|||||||||:..|.::..  :..||.::|:|:|.      |..:||.
  Fly   153 RFPYFK-----ANKRGWQNSIRHNLSLNKCFTKIPRSYDDPGKGNYWILDPSAEEVFIGETTGKL 212

Human   250 PRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAG--DSPGSQFSKWPASP 299
            .|:...:         ||:|.|..:.::.|....|.  .:|.|.:. :||.|
  Fly   213 RRKNPGA---------SRTRLAAYRQAIFSPMMAASPYGAPASSYG-YPAVP 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		6/41 (15%)
		FH_FOXO1	151..249	CDD:410834	37/105 (35%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		18/74 (24%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		6/19 (32%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459
		FOXO_KIX_bdg	423..504	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506
slp1	NP_476730.1	COG5025	<11..>230	CDD:227358	61/220 (28%)
		Forkhead	120..205	CDD:459732	37/115 (32%)