DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and fd19B

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_608369.1 Gene:fd19B / 33010 FlyBaseID:FBgn0031086 Length:260 Species:Drosophila melanogaster


Alignment Length:187 Identity:52/187 - (27%)
Similarity:84/187 - (44%) Gaps:36/187 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   130 PLSQHPPVP--PAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVK 192
            |:|:|....  .:.:...:.....|.:::.||....:|:.||..||.||:|||||||.|.:|:..
  Fly    26 PISKHNSGSSFSSCSSSSSNSSSDSMAAKSNAKPAFTYSALIVMAIWSSSEKRLTLSGICKWIAD 90

Human   193 SVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN--EGTGKSSWWMLNP--EGGKSGKSPRRR 253
            :.||::.:     .:.|:|||||||||:..|:||..  :..|:..:|.|:|  |....|::..|.
  Fly    91 NFPYYRTR-----KSVWQNSIRHNLSLNPFFVRVPRALDDPGRGHYWALDPYAEDLSIGETTGRL 150

Human   254 AASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSP---GSQFSKWPASPGSHSNDDF 307
            ..|                      :.|:..|..|   |..:.:.|.....|.|..:
  Fly   151 RRS----------------------NWQQNTGARPKVTGHPYQRMPYYGHGHGNGPY 185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 4/29 (14%)
FH_FOXO1 151..249 CDD:410834 40/101 (40%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 14/79 (18%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 0/2 (0%)
Nuclear localization signal 251..253 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 6/28 (21%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459
FOXO_KIX_bdg 423..504 CDD:465228
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537
FOXO-TAD 597..633 CDD:435506
fd19BNP_608369.1 Forkhead 58..140 CDD:459732 35/86 (41%)
Blue background indicates that the domain is not in the aligned region.

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