DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and fhl1

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_594272.1 Gene:fhl1 / 2541552 PomBaseID:SPAC1142.08 Length:743 Species:Schizosaccharomyces pombe


Alignment Length:611 Identity:151/611 - (24%)
Similarity:224/611 - (36%) Gaps:177/611 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    41 SPAPSG-----SAAANPDAAAGLPSASA------AAVSADFMSNLS---LLEESEDFPQAPGSVA 91
            |||.:.     |...:||||.....||.      ..||...:..||   .:..:.|  :.|....
pombe   185 SPADTNISNATSIIEHPDAANAHTLASLNQPPKHLTVSPSSIQRLSPQPYVRPTSD--ERPIETD 247

Human    92 AAVAAAAAAAATGGL-CGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSS 155
            ::|:|...|.....| .|....|....|||.....|..|..:|.|                    
pombe   248 SSVSAPKVANHDEELKQGKSTSPSDTVLHPDLNGSPDTGDATQKP-------------------- 292

Human   156 RRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLH 220
                  |||||:||.:.:.::..|::||..|.||:..:..|::     :....|.|||||||||:
pombe   293 ------NLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYR-----HQPPAWHNSIRHNLSLN 346

Human   221 SKFIRV---QNEGTGKSSWWMLNP------EGG--KSGKSP---RRRAASMDNNSKFAKSRSRAA 271
            ..|||:   ||| .||.|:|||:|      ||.  :..|.|   ...||..|.    |:....||
pombe   347 KAFIRIPRRQNE-PGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDT----ARENELAA 406

Human   272 KKKASLQSGQ-EGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQ 335
            .:...:.:|: |.......:..||...|.|.:..|        ||:     |.:...:.||:...
pombe   407 IQTKGISAGKTEQLNPQKETSRSKTHTSRGENVED--------RPQ-----SLLQNGIQPIIMRD 458

Human   336 DDL---------GEGDVHSMVYPPSAAKMASTL----------PSLSEISNPENMENLLDNLNLL 381
            ..|         ..|:..:   |...|..|.:|          |:.:  :|||....:.:.|.:.
pombe   459 GKLALNPEFFKNANGEQQA---PNEQAVQAISLLQQHINKQLGPAAA--NNPEQATAIANALAVA 518

Human   382 SSPTSLTVSTQ-SSPGTMMQQT---PCYS--------FAPPNTSLNSPSPNYQKYTYGQSSMSP- 433
            .:.......|| ..|..:.||.   ..|:        .|.|:.::.||||:.........::.| 
pombe   519 LAQKLQKQQTQMQGPQQVQQQAKRRKAYTSQQLNPAPTAMPHPNITSPSPSISVTQRPAVNVGPP 583

Human   434 ---LPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQN 495
               .|..| ..|.|.:.|.|                           .|:.||..        .|
pombe   584 PYVRPSAP-SKLPDTRQSIG---------------------------DPLPPGAM--------AN 612

Human   496 VMMGPNSV-MSTYGSQASHNK---MMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLT 556
            |..||:|| .|:|.|.||.:|   ..:.:.||.|.:...||   .|||        ::|..:.|.
pombe   613 VSAGPSSVRSSSYNSTASESKSEITSHQNLHTIPINKPFTS---DRPL--------YSSPNDTLE 666

Human   557 QVKTPVQVPLPHPMQMSALGGYSSVS 582
            :|:|..|     ..:|:::|..||.|
pombe   667 RVETGNQ-----GQRMNSIGNASSFS 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 9/26 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 7/41 (17%)
FH_FOXO1 151..249 CDD:410834 39/108 (36%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 29/130 (22%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 1/2 (50%)
Nuclear localization signal 251..253 0/1 (0%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 67/318 (21%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 23/111 (21%)
FOXO_KIX_bdg 423..504 CDD:465228 16/85 (19%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 10/32 (31%)
FOXO-TAD 597..633 CDD:435506
fhl1NP_594272.1 COG5025 1..564 CDD:227358 107/434 (25%)
Blue background indicates that the domain is not in the aligned region.

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