DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and mei4

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_595617.1 Gene:mei4 / 2540241 PomBaseID:SPBC32H8.11 Length:517 Species:Schizosaccharomyces pombe


Alignment Length:450 Identity:121/450 - (26%)
Similarity:185/450 - (41%) Gaps:104/450 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 228
            |||.||..||..|..|:||||.||.|:..:..|:     .|...||:|||||||||:..||:|:.
pombe    85 SYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYY-----LNHDGGWQNSIRHNLSLNKAFIKVEK 144

Human   229 -EG-TGKSSWWMLNPEGGKSGKSPR-RRAASMDNNSK-------------------FAKSRSRAA 271
             :| |.|..:|.::|:..::..|.| .|:.|.|:|||                   .|:.|||..
pombe   145 PKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSKKRPSSKCHEIKPLTTREIPLARKRSRLN 209

Human   272 KKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFD-NWSTFRP-----RTSSNASTISGRLSP 330
            ...:|  :...|:..:..::.|...:.|   ||.|.. |.:..:|     ...||:|:......|
pombe   210 SFNSS--TSTSGSSSNVAAEVSNDASQP---SNQDSSLNSNIVKPPLPPSNVQSNSSSSENVPKP 269

Human   331 IMTEQDDLGEGDVH----------SMVYP-PSAAKMA-------------------STLPSLSEI 365
            ....|:||...|.|          |.:|. |:...||                   ::..||...
pombe   270 NAETQEDLPTIDAHESSLYENVNDSRLYEVPACRNMALNTGYSDADPGYLRTSFRSNSHNSLPYS 334

Human   366 SNPENMENLLDNLNLLSSPTSLTVSTQSS--PGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQ 428
            :|.|  |::|....|:|..:|:..|..||  |.:|    |.|...|.....:|....|.:.|||:
pombe   335 ANEE--EDVLQADFLVSQQSSMVSSYVSSRDPHSM----PYYRREPIPLRPSSRFYEYTRPTYGR 393

Human   429 SSMS-PLPQMPIQTLQDNKSSYGGMSQYNCAPGL-----------LKELL-TSDSPPHNDIMTPV 480
            :..| ..|.....|..::.|||...|:  |||..           :|.|| ..|..|..|...|.
pombe   394 TDTSCSAPGAFCSTQINSPSSYINYSK--CAPSSPTLSLQKHREHVKSLLYVPDLTPSFDGSDPW 456

Human   481 DPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSS-HTHPGHAQQTSAVNGRPL 539
            :     |:|::|.:       .:...:..|:|.:.:|:.:. ...|....::|..:..||
pombe   457 N-----PSSQLLSE-------PLFDQHSFQSSLDDLMSVTCFRDSPELNHESSGYSSAPL 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158
FH_FOXO1 151..249 CDD:410834 37/86 (43%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 31/135 (23%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 0/2 (0%)
Nuclear localization signal 251..253 1/2 (50%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 70/308 (23%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 28/98 (29%)
FOXO_KIX_bdg 423..504 CDD:465228 23/93 (25%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 5/30 (17%)
FOXO-TAD 597..633 CDD:435506
mei4NP_595617.1 COG5025 1..517 CDD:227358 120/449 (27%)
Blue background indicates that the domain is not in the aligned region.

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