DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO1 and daf-16

DIOPT Version :10

Sequence 1:NP_002006.2 Gene:FOXO1 / 2308 HGNCID:3819 Length:655 Species:Homo sapiens
Sequence 2:NP_001367893.1 Gene:daf-16 / 172981 WormBaseID:WBGene00000912 Length:541 Species:Caenorhabditis elegans


Alignment Length:576 Identity:177/576 - (30%)
Similarity:248/576 - (43%) Gaps:139/576 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    31 EFSQSNSA-----TSSPAPSGSAAANPDAAAGLPSASAAAVSADF---MSNLSLLEE-------- 79
            :|||...|     ..||.||.....|.:.|.  |. |..:.|.||   ..||.|.::        
 Worm    20 KFSQDMQAWNCRELDSPLPSDITLHNLEPAR--PD-SGMSFSTDFDDDFFNLDLHQQERSASFGG 81

Human    80 ----SEDF--------PQAPGSVAAAVAAAAAAAATGGLCGDFQGPEA----GCLHPAPPQPPPP 128
                |:.|        |....|:....:...:...:...||...|..:    ..||      .|.
 Worm    82 VTQYSQQFLREKCSFSPYFHTSLETVDSGRTSLYGSNEQCGQLGGASSNGSTAMLH------TPD 140

Human   129 GPLSQHPPVPP---AAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWM 190
            |..|.....|.   .:..|......|.:::|||||||:|||:|||.||.:|.||||||:|:||||
 Worm   141 GSNSHQTSFPSDFRMSESPDDTVSGKKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWM 205

Human   191 VKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRR--- 252
            |::||||:|||||||||||||||||||||||:|:|:||||.||||||::||: .|.|::|||   
 Worm   206 VQNVPYFRDKGDSNSSAGWKNSIRHNLSLHSRFMRIQNEGAGKSSWWVINPD-AKPGRNPRRTRE 269

Human   253 RAASMDNNSK--FAKSRSRAAKKK-------ASLQSGQEGAGDSPGSQFSKWPASPGSHS--NDD 306
            |:.:::..:|  ..||| |.|||:       .||.|...|...:...|..       ||.  :||
 Worm   270 RSNTIETTTKAQLEKSR-RGAKKRIKERALMGSLHSTLNGNSIAGSIQTI-------SHDLYDDD 326

Human   307 -----FDNW-STFRPRTSSNAST--ISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLS 363
                 |||. |:|||||.||.|.  .|.|:||.      :|......:.:|....:....:||  
 Worm   327 SMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPA------IGSDIYDDLEFPSWVGESVPAIPS-- 383

Human   364 EISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKY--TY 426
                     :::|..:.:....:..:.     |..::|    ...|..|...:|.|:|.:.  ..
 Worm   384 ---------DIVDRTDQMRIDATTHIG-----GVQIKQ----ESKPIKTEPIAPPPSYHELNSVR 430

Human   427 GQSSMSPLPQMPIQTLQDNK-----SSYGGMSQYNCAPGLLKELLTSDSPPHNDIMT-------- 478
            |..:.:||.:.||....:.|     .:||........|  :..|.||:|.|...|.:        
 Worm   431 GSCAQNPLLRNPIVPSTNFKPMPLPGAYGNYQNGGITP--INWLSTSNSSPLPGIQSCGIVAAQH 493

Human   479 --------PVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQA--SHNKMMNPSSHTH 524
                    |:|.           :|:.:....:|.|....|  .|........|.|
 Worm   494 TVASSSALPIDL-----------ENLTLPDQPLMDTMDVDALIRHELSQAGGQHIH 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO1NP_002006.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..63 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..158 9/44 (20%)
FH_FOXO1 151..249 CDD:410834 72/97 (74%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 211..218 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..344 46/131 (35%)
DNA-binding. /evidence=ECO:0000269|PubMed:18786403 234..237 2/2 (100%)
Nuclear localization signal 251..253 2/4 (50%)
Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0 283..563 58/277 (21%)
Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0 363..459 16/102 (16%)
FOXO_KIX_bdg 423..504 CDD:465228 18/103 (17%)
Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0 462..466 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..537 4/20 (20%)
FOXO-TAD 597..633 CDD:435506
daf-16NP_001367893.1 FH_FOXO 176..255 CDD:410806 62/78 (79%)
Blue background indicates that the domain is not in the aligned region.

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