DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HECW1 and pub2

DIOPT Version :9

Sequence 1:	XP_016867371.1	Gene:	HECW1 / 23072	HGNCID:	22195	Length:	1639	Species:	Homo sapiens
Sequence 2:	NP_593926.1	Gene:	pub2 / 2542432	PomBaseID:	SPAC1805.15c	Length:	671	Species:	Schizosaccharomyces pombe

Alignment Length:	790	Identity:	195/790 - (24%)
Similarity:	321/790 - (40%)	Gaps:	277/790 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   860 IDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRT 924
            ||:.....||.|||..|.|:|:
pombe   149 IDDASGCAWETRIDEFGHVYYL------------------------------------------- 170

Human   925 IATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLL----LQS 985
                                            :|.|.|:       :|.::.:|:..|    |:.
pombe   171 --------------------------------KSPQLSV-------ISAISHEKLENLTPKQLKE 196

Human   986 PAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMI------LKVRRDARNFERYQHNRDLVNFIN 1044
            ...:|:.|.:..:.|..|.. |:|      :||::      |.||:..
pombe   197 VFSQFLFNNQSKSSLKINLE-YKV------IKHLLEHYPLALSVRQQV----------------- 237

Human  1045 MFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSA 1109
              |..:..||.|||::..:....:||||:::.||:.|||
pombe   238 --AVEKGPLPAGWEMRLSEDYHVYFVDHSTKTTTWSDPR-------------------------- 274

Human  1110 GEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLAR 1174
                                                    |.:||
pombe   275 ----------------------------------------DNVVA-------------------- 279

Human  1175 NHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSP 1239
                                     :|                                   |..
pombe   280 -------------------------SD-----------------------------------SVS 284

Human  1240 QNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYS 1304
            :|:..:|:.:        .:::.|:...|.:.|   ......:::|.:.|....|..::.:...|
pombe   285 ENTDSIQQIN--------DEYQRKIAYMYDRPE---MAVNDAQLQLKVSRATTFEDAYDIISKLS 338

Human  1305 RKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVEN 1369
            ..:::: ||.:.|..|:||||.|.|||||::||..:|||.|.||||:.:|.|.:||||:|:...:
pombe   339 VSDMKK-KLLIRFRNEDGLDYGGVSREFFYILSHAIFNPGYSLFEYATDDNYGLQISPLSSVNPD 402

Human  1370 HLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITD 1434
            ...:|||.||::|||:.|:..||..|..||||.:|:.|..|.|::.:||.:::||:|:|:|::.:
pombe   403 FRSYFRFVGRVMGLAIYHRRYLDVQFVLPFYKRILQKPLCLEDVKDVDEVYYESLKWIKNNDVDE 467

Human  1435 ILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEV 1499
            .|.|.|:|.|..||:....:|...|.|..|..:||..|::.:.:.::.....:|..||..|..|:
pombe   468 SLCLNFSVEENRFGESVTVDLIPNGRNIAVNNQNKMNYLKALTEHKLVTSTEEQFNALKGGLNEL 532

Human  1500 VDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLL 1564
            :...::.:|:..||:.::.|..:||:.||:..|:|| .|.:...::.|||..:..::.|::.:||
pombe   533 IPDSVLQIFNENELDTLLNGKRDIDVQDWKRFTDYR-SYTETDDIVIWFWELLSEWSPEKKAKLL 596

Human  1565 QFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTA 1629
            ||.||||.:|..||..:.||:|.|:|.|||.|.|:.||:|||||||||:|||.|...|.:||..|
pombe   597 QFATGTSRLPLSGFKDMHGSDGPRKFTIEKVGHISQLPKAHTCFNRLDIPPYNSKEELEQKLTIA 661

Human  1630 VEETSTFGLE 1639
            ::||:.||.|
pombe   662 IQETAGFGTE 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HECW1	XP_016867371.1	None
pub2	NP_593926.1	HUL4	1..671	CDD:227354	194/788 (25%)
		C2_Smurf-like	7..128	CDD:176028
		WW	243..275	CDD:197736	14/97 (14%)
		HECTc	317..669	CDD:238033	139/353 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910