DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1B and upSET

DIOPT Version :9

Sequence 1:	NP_001340274.1	Gene:	SETD1B / 23067	HGNCID:	29187	Length:	1966	Species:	Homo sapiens
Sequence 2:	NP_001261819.1	Gene:	upSET / 39551	FlyBaseID:	FBgn0036398	Length:	3146	Species:	Drosophila melanogaster

Alignment Length:	2352	Identity:	433/2352 - (18%)
Similarity:	654/2352 - (27%)	Gaps:	932/2352 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   113 NIRENFLRDMCK-KYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHV 176
            ||.|.::.::|: :..:......|...|.|:|:     :....:.|..|......|::.|.
  Fly   889 NIPEEYMCELCQPRAVDKARARALQRQKRKEHM-----LLVATQAANGAAAVAAGTTLSGG---- 944

Human   177 ELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSG-- 239
                           |.:|      ||:.|            :|...|....:||.:.|.|..
  Fly   945 ---------------LGSG------LPMSE------------ELQHRLASGLNGGFATGTGMSKK 976

Human   240 SSSVTPNSGGTPFSQDTAYSSCRL-DTPNSYGQGTPLTPRLGTPFSQDSSYSSRQ---------P 294
            |.....|||.|...:.|..|:..: ...|:.|.||| |...|....:.|...|:.         .
  Fly   977 SKKTKENSGSTSTLKKTKKSAVGMGGEKNASGSGTP-TGSSGKTSKKSSKRKSKSGGDGSSGGGS 1040

Human   295 TPSYLFSQDPAVTFK--ARRHESKFTDAYN--RRHEHHYVHNSPAV------------------- 336
            :|:...::..|...:  ...:|...|:.|:  .|...|.:...|::
  Fly  1041 SPALTAAEKHAANLRQWIENYEYAVTNHYSPELRARLHAIQKQPSLLQSIQNTENKALRQIQQQL 1105

Human   337 -TA--------------VAGATAAFRGSSDL-PFGAVGGTGGSSGPPFKAQPQDSATFAHTPPP- 384
             ||              .|||.... .|.|| |...:....|......:.:.|:.....:||||
  Fly  1106 STAGSAEQLEQRAQLIPYAGAKVLI-SSVDLSPHAPIHELRGKYMLTTQFRTQNPTVNMNTPPPS 1169

Human   385 -------AQATPA--------PGFKSAFSPYQT--------PVAHFPPP----PEEPTATAAFG- 421
                   |..||.        ||.:   :|.||        .||..||.    ||....|..:|
  Fly  1170 NYLNSFKAHKTPGQFVFFYQLPGVE---APMQTLRPDGSVPQVAQQPPSYLKGPEVCVDTRTYGN 1231

Human   422 --------ARDSGEFR------------------RAPA-------PPPLPPAE------------ 441
                    .|.:.|.:                  ||..       |..|...|
  Fly  1232 DARFVRRSCRPNAELQHYFEKGTLHLYIVALTHIRAQTEITIRHEPHDLTAVEQKKSHAAVIQPT 1296

Human   442 ----------------PLA-KEKPGTPPGPPPPD-----------------------TNSMELGG 466
                            ||| :::...||..|...                       |..:.:|.
  Fly  1297 STRCACDMGSDCLFALPLAVQQQLQAPPTQPRSSHRNKAAAAAAAAAAANSAAAIQLTMGLGVGA 1361

Human   467 RPTFGWS--PEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQME 529
            ....|.|  |...:...:.:.|||..|...|.   ..::.:..|...| ...|..|.........
  Fly  1362 TVAAGASVLPNSRNRSTSSSGESSQMGLNSPQ---LGQLNLGFKTSVT-ATSLTAPVPGVHCNNS 1422

Human   530 GSPISSSS-----SQLSPLAPFG---TNSQPGFRGPTPPSSRPSSTGLEDISPTPLPD------- 579
            |...|||:     |..|.|...|   ::|.|....|:|..::..|..|:. .|..:|.
  Fly  1423 GGSSSSSNNSCSVSMSSVLHDSGICTSSSSPSVSIPSPTPTQMQSPTLQQ-HPQQIPQQQLSLLQ 1486

Human   580 -SDEDEELDLGLGPRPPP------EPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGE 637
             |...:.....|...|.|      .|..|.||   .|.|.|.|       |.|::....||...:
  Fly  1487 RSPTQQHQQQILAALPTPMLTPMLSPQLPKPA---QQQAHVVL-------PQSQQTSLLQQQQSQ 1541

Human   638 DMEISDDEMPSAPITSA---------------------DCPKPMVVTP------GA--------- 666
                 ..:.|.|.|.:|                     ..|||..:..      ||
  Fly  1542 -----QSQEPLAVIAAAAAAQQPMATYFVRQPQQQQQQQSPKPQALVAQQQHVVGAQQQQHFLQQ 1601

Human   667 --------------AAVAAPSVL--APTLPLPPPPGFPPLPPPPPP------------------- 696
                          .||:|...|  |||..:..|.....:.....|
  Fly  1602 QQKQQQQQMADEARMAVSALQTLHAAPTSHIVSPIKVAAVQQQSQPQQQQQNTHQQPHNQQAVQQ 1666

Human   697 --------PPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLF 753
                    ...||.:|..|  .....|.|..|....|......|.|...|..:..|.....|.:.
  Fly  1667 QSNQLQQQQSQQPNYPQSP--QRQQKPQPVQHQPQIVISTGAQAIPATMPTKLSSPTKSAAPVIS 1729

Human   754 --PVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPP 816
              .:.....|.|:||:  ..|.....|.|       .|...|..|..||.|.||:
  Fly  1730 NNNITVSAQSSVVGGK--KTPAKHPQQQQ-------QQQQQPVTPVSAATAPAAT---------- 1775

Human   817 YRGPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLN 881
                       |...:..........:..|....|.::.|.::..|..|..:|:.::.:.|::..
  Fly  1776 -----------PSSSESKEDDVSASSTTTPTTRTPAKDKPKQSREDRKLEAILRAIEKMEKQEAR 1829

Human   882 RKMVEVVAFRAFDEWWDKKERMA-----KASLTPV-----KSGEHKDED---------------- 920
            .|               |..|.:     :||.:|.     .|.....||
  Fly  1830 GK---------------KDTRQSSGGKRQASNSPASPNKRNSSNSISEDVETPTSTNSAAAAAQR 1879

Human   921 RPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPST 985
            |.|.|.:::..|..:        ..|||.|.|...         ||::.....|.|:...|..|.
  Fly  1880 RNKKKRKVSRSLNNN--------TNGLGSGGGSNN---------KRRKSIVVESDGESHALTNSE 1927

Human   986 SVDE-----------EDE-------------------ESERERDRDMADTPCELA---------- 1010
            |.|:           ||:                   :|...:...:..||..::
  Fly  1928 SEDQGQHPQSHHSGSEDQAAGLLLALAHNNSSPNEPFKSPLSQSHSLPATPASVSSACLLIEAAM 1992

Human  1011 -------------------KRDPKGVGVRR----------RPARPLELDS---------GGEED- 1036
                               |..|.|...::          .......|||         .||.:
  Fly  1993 GPLQQQPAPASASPSLAEFKYPPGGAKTKKSLMSSWFQQAEQQHASGLDSLVQAAMSEINGEREQ 2057

Human  1037 -----EKESLSASSSSSASS---SSGSSTTSPS---------SSASDKE--------EEQESTEE 1076
                 :.|||.|.:......   .:.|:|..|:         :::|.|:        ||....:|
  Fly  2058 LQRQPQGESLPAPALLKVEQFIHQAESTTAVPAREQLHLPLQNNSSVKKRWLRQAISEETTPVDE 2122

Human  1077 EEEAEEEEEEEVPRSQ----------------------LSSSSTSSTSDKDDDDDDSDDRDESEN 1119
            .::::.:.....|..|                      :.|:.|:..||:...|...:.:||:|
  Fly  2123 LQQSQNQSVTATPSPQPVPTVSPLANGFSTPLKKRRLVVVSNGTNVESDETHIDVIGEPKDEAE- 2186

Human  1120 DDEDTALSEAS-EKDEGDSDEEETVSIVTS---------------KAEATSSSESSESSEFESSS 1168
              |:.|::|.. |.:....::::.|.|:.|               |.|...:|.:::..:.:...
  Fly  2187 --ENVAMTELKVEIENHHQEQDDDVDILRSPSPGTHQIVAEDNLVKIEPEDTSAAADDVKIDVER 2249

Human  1169 ESSPSSSEDEEEV-VAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEE 1232
            |.|.:..:.||.| |.|||||:.|:|....:|          .|:.|:       |.|:...:|.
  Fly  2250 EESQACDKFEEMVKVKREEEEQREKEIKQLQE----------RQEHEQ-------PKVEPAPVEP 2297

Human  1233 EVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPE---EPGLS-QEGAMLLSPEPPAKEVEA 1293
            :::.......|:..||           :|....:||.:   :||.| ......::..|.|..:.|
  Fly  2298 KLENTVAKAEPKVEPS-----------QEIVSKKEPTKVEPKPGESLLRSTATVTATPTAATIAA 2351

Human  1294 -------------RPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDA 1345
                         |||          |::|.||....| .|:..||.|....||
  Fly  2352 TTLLDVSKVAFKTRPP----------LKLEDEPQKKKP-KLESILPAPVATVPP----------- 2394

Human  1346 SHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGG-------EPPLSGGSSGLSLSSPQV 1403
              .||||.|.|.:  ..|..:..:.|.|.:|.|.|::...       |..||..::.:|....:.
  Fly  2395 --VSVPPIPAASN--ATTSAVTNTAAASLTTTTAPSSTKNLTEHDIQERLLSFHAANISYLQSRN 2455

Human  1404 PGSPFSYPAPSPS----LSSGG------------------------------------------- 1421
            ..:..:..:.|||    .||||
  Fly  2456 KKATAALTSASPSQKSNSSSGGSGTESKKSSKDKDEKRDKEKQLKKSKKEKKKSKDKEKQKAAVN 2520

Human  1422 ---------------LPRTPGRDFSFTPTFSEPSGPL---------------------------- 1443
                           .|..|....|..|....||.|:
  Fly  2521 VNSTSQIVDTKKKTTQPSKPDSKSSIAPVLVPPSLPVATANGKTKHTAYNNVDQQQQQQMRRRTM 2585

Human  1444 ---LLPVCPLP------------------TGRRDERSGP----LASPVLLETGLPLPLPLPLPLP 1483
               :.||.|.|                  |....|.:.|    |:|.:||.:...|.|||..|..
  Fly  2586 SMCITPVTPTPVVTPSPLHGTPPSTKKRQTNFEQELTKPNSQILSSSILLNSSKGLGLPLAAPTV 2650

Human  1484 LALPAVLRAQA-------RAPTPL---PPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVR 1538
            :::|..::.|.       :..||.   |..|.|.:||         |:.........|:.|...:
  Fly  2651 VSVPTAVQQQQHRKENNHQEATPASGGPMSLAAAIAS---------GKLNAISRRRESMCGSRQQ 2706

Human  1539 PP-AGAALGRELLLLPGQPQTPVFPSTHD-----------------------------PRTVTLD 1573
            .. ..|||.:|........:.......||                             |.||..:
  Fly  2707 QALIAAALKKEKKEKKKSKKKDREKQKHDKQKGKEKEREKDKEKDNKQKTNHIQKPAHPTTVPAN 2771

Human  1574 FRNAGIPAPPPPLPPQP-------PPP-----PPPPPVEPTK------------LPF------KE 1608
            ......|||.|.|.|.|       |.|     |.|.|:..|:            |||      |.
  Fly  2772 SMPISAPAPVPVLVPTPVTTPKAAPIPVLITQPTPSPIHVTQPLVNNCSTKVASLPFYNTIYGKL 2836

Human  1609 LDNQWP-SEAIPPGPRGRDEVTE------EYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSP-- 1664
            .|...| |..||        ||.      ||:|..||        |......|.|.|...::|
  Fly  2837 QDPSTPTSSPIP--------VTNTMPSLAEYLESTKS--------KTTALSAVKPIGIAAVTPLS 2885

Human  1665 ---------PQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWV 1720
                     |..|..|......:.:                    |.|....|   ..||..|.|
  Fly  2886 SAITPAKVAPSSLEMPPPATTPLKL--------------------YTRTASHD---PRLNPMLTV 2927

Human  1721 YHPSTSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIPA 1785
            ..|:      ...||...|.|:                 ::|:    |.|.|..|......:.|.
  Fly  2928 PDPT------PMPKRKLSISEY-----------------RMRH----RPSVDTAPTTPTTPTTPT 2965

Human  1786 QPHASTRAGSER 1797
            .|  :|..||.:
  Fly  2966 TP--TTPPGSNK 2975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD1B	NP_001340274.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		RRM_Set1B	101..193	CDD:240993	12/80 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..302		19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..660		87/461 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..719		12/72 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1462		135/780 (17%)
		Trypan_PARP	<1237..1308	CDD:330686	15/87 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1501..1541		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1606		19/103 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1636..1668		8/42 (19%)
		N-SET	1679..1821	CDD:314603	22/119 (18%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1745..1750		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1767..1800		9/31 (29%)
		SET	1834..1949	CDD:214614
		PostSET	1950..1966	CDD:214703
upSET	NP_001261819.1	PHD_MLL5	856..899	CDD:277025	3/9 (33%)
upSET	NP_001261819.1	SET	<1221..1273	CDD:214614	7/51 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030