Protein Alignment EMC1 and emc1

DIOPT Version :10

• Sequence 1: NP_001362749.1
• Gene: EMC1 / 23065
• HGNCID: 28957
• Length: 996
• Species: Homo sapiens
• Sequence 2: XP_021329317.2
• Gene: emc1 / 565399
• ZFINID: ZDB-GENE-060810-98
• Length: 964
• Species: Danio rerio
• Alignment Length: 992
• Identity: 664/992 - (66%)
• Similarity: 796/992 - (80%)
• Gaps: 37/992 - (3%)

Human     8 RFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLE-FSPGSKKLVVATEKNVIAALNSRTG 71
            |..:..:||..|:||:|||||||||||||:|||:||..: .|..||||:|||:|||.|:||||||
Zfish     7 RLAISVSLLYTASAVFEDQVGKFDWRQQYIGKVRFALFDTHSQASKKLLVATDKNVFASLNSRTG 71

Human    72 EILWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWEITLDSGSFQALGLVGL 136
            ::.||||||...||.:||:|:||||.:.|...||::|||||.:|||.||..||||||||..|||:
Zfish    72 DLFWRHVDKTGPEGHIDALLMHGQDAVVVVGNGRLLRSWETTVGGLKWETVLDSGSFQAAALVGV 136

Human   137 QESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYSYGSGVVWALGVVPFSHVNIVK 201
            |:.|:|:|||||:|:|||.||||...|||:||:||::.||.:||.|:|:|:.|||:|.||:.||:
Zfish   137 QDYVKYVAVLKKSTIALHDLSSGSQTWVENLPDSDTVQYQTIYSGGNGLVFVLGVLPNSHIVIVE 201

Human   202 FNVEDGEIVQQVRVSTPWLQHLSGACGVVDEAVLVCPDPSSRSLQTLALET--EWELRQIPLQSL 264
            :.:|||||:.:..|...|:..|..:|.||...:|:|.|..::||.|..|.:  :.|:|||.||:|
Zfish   202 YKIEDGEIMNKKSVEAAWMSSLESSCVVVSSGILMCVDQITQSLYTQPLHSAEQTEMRQIHLQTL 266

Human   265 DLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHYALLQYHYGTLSLLKNFPQTALVSFATTGE 329
            |||..|||||.:..|||:|.....|:|.|.|||.|:.|||...|.::.|::|..:.|.:|||:||
Zfish   267 DLEVASGFQPVLTSTQPSPAHPPLAEFILQLSPEHHILLQLKDGLIAPLRDFSPSYLAAFATSGE 331

Human   330 KTVAAVMACRNEVQKSSSSEDGSMGSFSEKSSSKDSLACFNQTYTINLYLVETGRRLLDTTITFS 394
            |||.|||                        |.|:..||     :|||:..:||||.|||||.:.
Zfish   332 KTVVAVM------------------------SPKNDTAC-----SINLFSADTGRRHLDTTIIYH 367

Human   395 LEQSGTRPERLYIQVFLKKDDSVGYRALVQTEDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVD 459
            .:..|.:|.:||:..|||||||||||.:|||||..|.|||| .|:|| |.|||:||:||.:||||
Zfish   368 TDPYGGKPNKLYVHAFLKKDDSVGYRVMVQTEDLTLTFLQQ-PGRVV-WMREEALADVVNMEMVD 430

Human   460 LPLTGAQAELEGEFGKKAAIQDGLLGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEIN 524
            |||||.||||||||||||   ||||.|.|||||||.||||||.:||||:|||||||||.:||||.
Zfish   431 LPLTGTQAELEGEFGKKA---DGLLPMVLKRLSSQFILLQAWMAHLWKLFYDARKPRSSVKNEIT 492

Human   525 IDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKPDSSFKLMVQRTTAHFPHPPQ 589
            ||||:||||||||||||||||||||||:|.|||:||||||.|:||:|.|||:|||||||||||||
Zfish   493 IDTLSRDEFNLQKMMVMVTASGKLFGIDSRSGTVLWKQYLENIKPNSFFKLIVQRTTAHFPHPPQ 557

Human   590 CTLLVKDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTA 654
            ||||:||:::|:.|||||||||||.||::.|.|.|||||||||||:||||:||||||||:.||||
Zfish   558 CTLLIKDQDTGLGSLYVFNPIFGKKSQISVPALPRPILQSLLLPVIDQDYSKVLLLIDDQNKVTA 622

Human   655 FPATRNVLRQLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSS 719
            ||:|:|:|:||.|.|.||||||||:.||:|.|:|||.||:|||.||:.||.|||:||.|||||::
Zfish   623 FPSTKNILQQLQETASSIFFYLVDSNQGKLSGFRLRTDLSTELIWEVVIPTEVQKIVAVKGKRAN 687

Human   720 EHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAKGP 784
            ||||||||||||||||||.||||||||:|||||.|.||:|:||||||||||||:|.:||:||:||
Zfish   688 EHVHSQGRVMGDRSVLYKYLNPNLLAVITESTDTHQERSFVGIFLIDGVTGRIVHEAVQRKARGP 752

Human   785 VHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISA 849
            ||.|||||||:|.|||:|.|||||:||||:||.|.||:|.|||||||..|||||||||||:.||.
Zfish   753 VHCVHSENWVIYVYWNSKFRRNEFSVLELFEGAELYNSTVFSSLDRPHPPQVLQQSYIFPAPIST 817

Human   850 MEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFIN 914
            :|||:||:||||||||:|||||.||||||..|||||||:.:|||||||||||:|::.|..|.|||
Zfish   818 LEATLTEKGITSRHLLVGLPSGNILSLPKMFLDPRRPEVVSEQSREENLIPYAPEMPIRTEWFIN 882

Human   915 YNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFAT 979
            |||||||:||||||||||||||||||||||||||||:|||||||||||||||||||||.||.|||
Zfish   883 YNQTVSRVRGIYTAPSGLESTCLVVAYGLDIYQTRVFPSKQFDVLKDDYDYVLISSVLLGLFFAT 947

Human   980 MITKRLAQVKLLNRAWR 996
            ||:||||:|||||||||
Zfish   948 MISKRLAEVKLLNRAWR 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_001362749.1	PQQ_2	59..>218	CDD:433144	93/158 (59%)
		EMC1_C	790..995	CDD:462261	166/204 (81%)
emc1	XP_021329317.2	None