Protein Alignment EMC1 and EMC1

DIOPT Version :10

• Sequence 1: NP_001362749.1
• Gene: EMC1 / 23065
• HGNCID: 28957
• Length: 996
• Species: Homo sapiens
• Sequence 2: NP_649747.1
• Gene: EMC1 / 40933
• FlyBaseID: FBgn0037530
• Length: 915
• Species: Drosophila melanogaster
• Alignment Length: 1059
• Identity: 355/1059 - (33%)
• Similarity: 507/1059 - (47%)
• Gaps: 207/1059 - (19%)

Human     1 MAAEWASRFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEKNVIAA 65
            |..:|.......|.||...:|:||||:.|||||...||.:|.:.::.:....:::|.|.:.|:|:
  Fly     1 MQEKWLLPALSLALLLGTCSALYEDQIKKFDWRGVNVGALKQSRVDLNHFQPRILVTTYEGVVAS 65

Human    66 LNSRTGEILWRHVDKGTAEGAVDAMLLH--------------------GQDVITV-SNGGRIMRS 109
            |..:|||::||.|.:....|  |..||.                    |.|::|| .:...::|.
  Fly    66 LCVKTGELVWRQVLEQKPRG--DVKLLQVSGFADDSSDTAAAPMGSNMGFDMLTVQGHAPALVRG 128

Human   110 WETNIGGLNWEITLDSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIH 174
            |.||:|.|.||     .|...:.....|:::                      |:    .|.|:.
  Fly   129 WNTNMGALEWE-----WSIMPMNTERAQDAM----------------------WI----YSKSVL 162

Human   175 YQMVYSYGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQV-RVSTPWLQHLSGACGVVDEAVLVCP 238
            |.::      ..|.      ||:.:..:....|...... :|..||:  .|.:| .:.....||.
  Fly   163 YHVL------PAWR------SHLEVTAYFASSGHSTGSTSKVIAPWI--TSESC-TLSGTFYVCT 212

Human   239 DPSSRSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHYALL 303
            |...                  |.||||...||   :|:.|........:.|
  Fly   213 DGKQ------------------LISLDLVSKSG---QVIRTSLEAEPKGKTQ------------- 243

Human   304 QYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSS------SEDGSMGSFSEK--- 359
                                 |.||...|..|......|.|..|      |...::|||:.:
  Fly   244 ---------------------ALTGLNGVVIVDGKPISVNKDQSICGDLRSSSFAVGSFNYRKVL 287

Human   360 --SSSKDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERL---YIQVFLKKDDSVGY 419
              :.....:...|..|..|            ......||||...||..   .:..|..|....|
  Fly   288 AYADLSSGILRINALYLDN------------CAPAAELEQSLPFPEHFGTPSLSNFDCKQKRNG- 339

Human   420 RALVQTEDHLLLFLQQLAGKV------VLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKA- 477
                :.::.|.||.......|      |.||||||||.|:..:.|||||...:..||.|...||
  Fly   340 ----EGKNCLFLFSSTSESIVAVQHGRVRWSREESLANVIDSQFVDLPLADTEGTLENEMKGKAG 400

Human   478 ---AIQDGLLGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINI-----DT----LAR 530
               :.:..:...||:|:::|.:.:::...|:                 |.:     ||    |.|
  Fly   401 DFTSFERDIASAFLRRITTQAVQIRSLFLHV-----------------IGLGPPPTDTQRAGLVR 448

Human   531 DEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNV---KPDSSFKLMVQRTTAHFPHPPQCTL 592
            |.|.|.||:|::|.:||:|||::.||...|:.:||||   ..|...:|:|||:..|||..|.||:
  Fly   449 DSFGLHKMLVLLTRAGKIFGIDNVSGKHHWQLHLPNVIGFANDEQMRLIVQRSAKHFPLQPLCTI 513

Human   593 LVKDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPA 657
            |.|:..||...||.||||.||.::.....|...|.|..||...::|:.|.:||:|...||..:|
  Fly   514 LGKNAVSGNGVLYRFNPITGKVAEGGLVQLDYRIKQLSLLGETEKDFLKGILLLDASNKVHVYP- 577

Human   658 TRNVLRQLHELAPSIFFYLVDAEQGRLCGYRLR---KDLTTELSWELTI--PPEVQRIVKVKGKR 717
                 .....||..::.|..|.:...|.||.::   ..|::...|...:  ....|:|:.|.||.
  Fly   578 -----EHAAPLADGMYLYTADLKTAELAGYFVKYAGGQLSSTHIWNARLGGHNSEQQIIGVAGKN 637

Human   718 SSEHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAK 782
            ..|||||||||:||||||||.:||||:|.||::.|:.| ::.:.::|:|.|:|.::.:...:|.:
  Fly   638 PIEHVHSQGRVLGDRSVLYKYINPNLVAFVTQAPDSTH-KSVLNLYLVDVVSGSVVFTMTHRKVR 701

Human   783 GPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSI 847
            .|:.|||||||:.|.|:|.|.||.|.|.:|||||..|.|::.:|||..|.:|.|.:||||.|:.:
  Fly   702 APLSIVHSENWLAYSYFNEKLRRTEITTIELYEGKSQANSSVWSSLQAPPMPLVERQSYILPTIV 766

Human   848 SAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERF 912
            .|:..||||||||::|:|||..||:|:.:|..|||||||...|.|.|||..|||.|::.:..|..
  Fly   767 EALRETITERGITNKHVLIGTASGSIVEMPWHLLDPRRPIASTTQGREEGAIPYIPELPLPTESH 831

Human   913 INYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVF 977
            |||||||:|:|.||||||||||||||||.|||::.|||.|||.||:||:|:||:|||.||..|..
  Fly   832 INYNQTVARLRNIYTAPSGLESTCLVVATGLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTS 896

Human   978 ATMITKRLAQVKLLNRAWR 996
            .::|.|.||..|||.:||:
  Fly   897 GSLIVKHLASRKLLKQAWK 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_001362749.1	PQQ_2	59..>218	CDD:433144	36/180 (20%)
		EMC1_C	790..995	CDD:462261	118/204 (58%)
EMC1	NP_649747.1	EMC1_C	709..914	CDD:462261	103/204 (50%)