Protein Alignment EMC1 and emc-1

DIOPT Version :10

• Sequence 1: NP_001362749.1
• Gene: EMC1 / 23065
• HGNCID: 28957
• Length: 996
• Species: Homo sapiens
• Sequence 2: NP_493980.1
• Gene: emc-1 / 173524
• WormBaseID: WBGene00019209
• Length: 946
• Species: Caenorhabditis elegans
• Alignment Length: 1062
• Identity: 333/1062 - (31%)
• Similarity: 507/1062 - (47%)
• Gaps: 192/1062 - (18%)

Human     8 RFWLWATLLIPAA--AVYEDQVGKFDWRQQYVG---KVKFASLEFSPGSK--KLVVATEKNVIAA 65
            |..|..|:.|.|:  |::|||.||||||:|.||   |:.|..:    |||  :|:|:|.::|:|:
 Worm     2 RLLLLVTIAIFASVTAIFEDQAGKFDWRKQLVGCPAKITFDKV----GSKSDRLIVSTAQSVLAS 62

Human    66 LNSRTGEILWRHV---DKGTAEGAVDAMLLHGQD---VITVSNGGRIMRSWETNIGGLNWEITLD 124
            |...||.|.||.:   ..|:..|     |...:|   :.::|..||.:|.|..|.|.|..::.:
 Worm    63 LVLNTGNIGWRQIMENPSGSTNG-----LTFTKDREYIYSISEDGRSVRVWNKNNGVLAHQLPI- 121

Human   125 SGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYSYGSGVVWAL 189
              |.|...:..:..:.:.:.|....||.:..|  |..|.||.:.....:.:...:.....|:
 Worm   122 --SEQKSEIQAIHVTNQRLHVASGRTLVVFRL--GDEKPVETVISKTELTFSAFFQQDDVVI--- 179

Human   190 GVVPFSHVNIVKFN----------VEDG--EIVQQVRVS--TPWLQHLSGACGVVDEAVLVCPDP 240
                  ||:.:| |          .|||  |.::.|.:.  .|...|       |.||.|.|...
 Worm   180 ------HVSALK-NAGKSIELSKITEDGAFEPLKTVEIKDFEPKNCH-------VQEAYLSCSTG 230

Human   241 SS--------RSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSP 297
            |:        :.:|.:.||||                                      .|.:|
 Worm   231 STLQIVDIFRQKVQKIQLETE--------------------------------------ILEIS- 256

Human   298 SHYALLQYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSSSEDGSMGSFSEKSSS 362
                    .:|.|.|.:......:|..  |.|...        :|:||.....|.....:|...|
 Worm   257 --------GHGPLILARGAKNAQIVEI--TAENGA--------QVRKSVDIGAGEALGITENHES 303

Human   363 KDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERLYIQVFLKKDDSVGYRALVQTED 427
                .....:..:.:..|.:........:..:.....:.|:    .:|.:|:|......:|..:.
 Worm   304 ----VIVTSSDAVRVVFVNSATHFSAKRVKMAENLENSAPK----SIFGRKNDKDWEIVIVGEDC 360

Human   428 HL-LLFLQQLAGKVVL-WSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKAAIQDG---LLGMF 487
            |: .:.:.|.:..|.| |||||||...|.:|||||||:.:|..:|.||      :||   ::..|
 Worm   361 HVEFVTVDQNSKSVNLEWSREESLITAVSVEMVDLPLSESQQMIEDEF------EDGESNIISAF 419

Human   488 LKRLSSQL-ILLQAWTSHLWKMFY---DARKPRSQIKNEINIDTLA------------RDEFNLQ 536
            ::|:..|. .|.:..|..:.|:.|   ...|..:.:.:.||....|            ||.|||:
 Worm   420 IRRIQVQFGQLCRQITRSIEKVIYVVTSITKNGNGVADFINSVRSASGSGSAASGPFERDYFNLR 484

Human   537 KMMVMVTASGKLFGIESSSGTILWKQYL-----PNVKPDSSFK--LMVQRTTAHFPHPPQCTLLV 594
            |::::.|::|.:|||:|:.|..|||.:|     |...|....|  |.|||||||:......:::.
 Worm   485 KVIIVATSTGTVFGIDSADGRYLWKLWLGEHFQPLESPFDGEKVPLFVQRTTAHYQLDGLASVVF 549

Human   595 KDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATR 659
            .:|.:....:..|||:.||  .|:...|..|:.:..||||....:...::||....::..||:.
 Worm   550 SNKLTHNGVIVSFNPMVGK--VVSRNELGYPVKRLSLLPVHTHKHVYPVMLIGKNEEIKIFPSI- 611

Human   660 NVLRQLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTEL---SWE----LTIPPEVQRIVKVKGKR 717
             ...:|....|  :.||:|.:...:.|  |:.|::::.   .|:    ||...:   |:.||||.
 Worm   612 -TPEELSATTP--YLYLLDIQSQTVQG--LKIDISSQKITPVWQGNLGLTAQDD---IIAVKGKS 668

Human   718 SSEHVHSQGRVMGDRSVLYKSLNPNLLAVVT-ESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKA 781
            .::.|||||||:..|.|.||.:||||.|:.: ...|.|     :.|.|:|.|||:|:||:...||
 Worm   669 FNQKVHSQGRVLVTREVQYKYVNPNLAAIASINRADQH-----MTITLVDIVTGQIVHSASIGKA 728

Human   782 KGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNA--TAFSSLDRPQLPQVL-QQSYIF 843
            ..|:|:||||||:.|.||:.|.||.|..::|||||||:.:.  ..|.|....:||.|: |||||:
 Worm   729 AKPIHMVHSENWIAYSYWSDKGRRTELGIIELYEGTEEQHTQKEVFDSKIAEKLPPVVAQQSYIY 793

Human   844 PSSISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIH 908
            ...:.||..:.||:|:|:|.:|:..|||.|..:.:.|||..||...|:..|||.:|.|.|::.:.
 Worm   794 AQGVDAMSVSETEQGLTTRSILVAHPSGNIHEVSRRLLDANRPMELTQAMREEMMIGYMPEIAVA 858

Human   909 AERFINYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLF 973
            .|..|||||||.|:|||.|:|||||||.||:|||.|::.||:.||..||:||||:|:||||.||.
 Worm   859 TEEMINYNQTVHRVRGIKTSPSGLESTSLVLAYGTDLFFTRLVPSGTFDILKDDFDHVLISLVLT 923

Human   974 GLVFATMITKRLAQVKLLNRAW 995
            |||..:.::||||:...|...|
 Worm   924 GLVVGSYVSKRLARSNALASQW 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EMC1	NP_001362749.1	PQQ_2	59..>218	CDD:433144	40/178 (22%)
		EMC1_C	790..995	CDD:462261	103/207 (50%)
emc-1	NP_493980.1	WD40	80..>176	CDD:475233	22/105 (21%)
		EMC1_C	737..945	CDD:462261	103/207 (50%)