DRSC/TRiP Functional Genomics Resources

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Protein Alignment SETX and eri-7

DIOPT Version :10

Sequence 1:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens
Sequence 2:NP_491374.2 Gene:eri-7 / 172047 WormBaseID:WBGene00016566 Length:625 Species:Caenorhabditis elegans


Alignment Length:587 Identity:142/587 - (24%)
Similarity:242/587 - (41%) Gaps:167/587 - (28%)


- Green bases have known domain annotations that are detailed below.


Human  1900 NQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDF------------NEDQKKAIETAYAMVKHS 1952
            |.:.:..|..||.....:|:|.:.....|. |..|            ||.|:.||:.|....:  
 Worm    21 NPVYQYTLEDNPESLTLQDVLESHMTDPIE-LNSFDSMEKEAGIPFSNEKQRTAIKMALNENR-- 82

Human  1953 PSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELM 2017
                |:..|.|||||||:.|:..||.||:  .|:|              :|:|.||:..|     
 Worm    83 ----KLVCIQGPPGTGKTFTLTLLLCRLI--QQKK--------------QVVVLAPTREA----- 122

Human  2018 KKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHK 2082
                             |.|      :|:..:|::....:|.                |..|:..
 Worm   123 -----------------LAN------IRMMTKKTLKRMGIKV----------------HEHALMD 148

Human  2083 RKEFLDYQLDELSRQRALCRGGREIQRQ----ELDENISKVSKERQELASKIK-----EVQGRPQ 2138
            ..|:.|. :::..|........|::::.    |:.||:  :.:.||.:.::::     ||.|.  
 Worm   149 TNEYRDV-INKSDRALMAAEEVRDLRKAFDNGEITENV--LDEMRQSIINRVRNEVGAEVIGN-- 208

Human  2139 KTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLI 2203
                        :....:|.|...::...:.:...|..| |:|||.|..|.:| .|.:::..:::
 Worm   209 ------------VRVAFATIGASFVDFVMKHKKFDPCLC-IIDEAAQVMEAQT-WPAVYKMKRIV 259

Human  2204 LVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFP 2268
            :.|||||||..|.:.:|:.:|...|:|.   |:||:....:.|      .|..|||.:..|..:.
 Worm   260 MAGDPKQLPALVFTDEAKAFGLQNSVMD---RILEKKNNFSWI------MLENQYRSNAKIATWS 315

Human  2269 SNYVYNRNLKTNRQTEAIRCS--------SDWP------FQP--------------------YLV 2299
            :...|:..|||:     ::|.        :..|      |.|                    :.|
 Worm   316 NTCFYHNQLKTD-----VKCHEYSLHTILNPQPKKFRNLFDPLVLIDTSLERDVEKRLETYEHAV 375

Human  2300 FDVGDGSERRDNDSYINVQEIKLVM-EIIKLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEF 2363
            ||....::.:...||.|:.|.|:.: ...:|:|   ..|...:|.|||.||.|.:::.| |.:||
 Worm   376 FDTNSINKTKQGFSYANLAEAKIAIGHYQRLLK---YGVQPSDIAIITPYKGQTSLVTK-LMEEF 436

Human  2364 DRKG------PAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFIL 2422
            ..:.      ...:.|||:.||::.:.||.|.||:|. :.::||::.|:||||.|||||.....:
 Worm   437 GAETGYTDFVQTTIGTVDSVQGKEYEVVIFTMVRSNP-RKTMGFVSELRRLNVVITRAKRHFMFI 500

Human  2423 GH 2424
            |:
 Worm   501 GN 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETXNP_001338457.1 SEN1_N 37..>351 CDD:432746
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604
DEXXQc_SETX 1934..2259 CDD:438712 77/345 (22%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 3/16 (19%)
AAA_12 2225..2424 CDD:463780 64/239 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706
Necessary for nuclear localization 2690..2706
eri-7NP_491374.2 TIGR00376 20..510 CDD:273041 142/587 (24%)
Blue background indicates that the domain is not in the aligned region.

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