DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SETX and setx

DIOPT Version :9

Sequence 1:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens
Sequence 2:XP_002936221.1 Gene:setx / 100145435 XenbaseID:XB-GENE-966858 Length:2535 Species:Xenopus tropicalis


Alignment Length:2873 Identity:1217/2873 - (42%)
Similarity:1619/2873 - (56%) Gaps:508/2873 - (17%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSTCCWCTPGGASTIDFLKRYASNTPSGE-FQTADEDLCYCLECVAEYHKARDELPFLHEVLWEL 64
            ||||.||||||....|.||:||:.....| |..|::|||||::||.|||:.|||:|.||:.||::
 Frog     1 MSTCRWCTPGGVPATDLLKKYAAKELHNEDFLGANDDLCYCMQCVVEYHQLRDEVPHLHKALWQI 65

Human    65 ETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERV 129
            ||.|||...||||:.||.:||||::|:.:||..||..||.:||:.||||||||||||||||::.|
 Frog    66 ETTRLITQLEKSMQEEIDEDDELFLVEEDGEKQLFGFTGPNFESNLRVPLLEILKYPYLLLNKHV 130

Human   130 NELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLL 194
            .|||.||||:|||||..|||::|.||:||.||||:|.||||||:|||..|||||||||||:||..
 Frog   131 TELCTEALCKMEQANNPFQVYEKLPGVYLLLVHPSETVRRWAIMTARTQGKVDRDDYYDLKEVFT 195

Human   195 CLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKSYWLGICMLLTILEEQAMDSLLLG 259
            ||||||||||.|:||||.:|.:|:|||||||||:||.:|||:||||||||||:|||||||||||.
 Frog   196 CLFKVIELGLFENPDIYGNSEIEEGKLILLPSHLYDISNYKNYWLGICMLLTVLEEQAMDSLLLS 260

Human   260 SDKQNDFMQSILHTMEREADDDSVDPFWPALHCFMVILDRLGSKVWGQLMDPIVAFQTIINNASY 324
            .||||||||||||.|::..:|:|.:||||||||||:|||||||||||||:|||.||||||::.||
 Frog   261 PDKQNDFMQSILHVMDKTTEDESTNPFWPALHCFMIILDRLGSKVWGQLIDPIQAFQTIISSPSY 325

Human   325 NREIRHIRNSSVR-TKLEPESYLDDM-VTCSQIVYNYNPEKTKKDSGWRTAICPDYCPNMYEEME 387
            ..||..||||:.| ||:||.:...|| ::|||:||::..|||.:|:||:.||.||:||||||||:
 Frog   326 TSEIETIRNSNRRPTKMEPHNDECDMDISCSQMVYSFKTEKTNQDTGWKKAINPDHCPNMYEEMQ 390

Human   388 TLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIAQVVNHLYSEVKEVLNQTDAVCD 452
            :||::||||||||||||:||||||:|:|||:||||:|||.||.:|::|||.|:|:||||....||
 Frog   391 SLANILQSDIGQDMRVHDSTFLWFLPYVQSVMDLKELGVPYIIEVIHHLYFEIKDVLNQRVQQCD 455

Human   453 KVTEFFLLILVSVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFTRSSEKSSGNCSKGTAM 517
            ||||.|:|:|||:||||||||||:|||||..:||||:|:|:.||.....          :|.|..
 Frog   456 KVTELFVLVLVSIIELHRNKKCLYLLWVSCHKWVEALVRCSLLPAKDMQ----------AKTTPK 510

Human   518 IS-SLSLHSMPSN-SVQLAYVQLIRSLLKEGYQLGQQSLCKRFWDKLNLFLRGNLSLGWQLTSQE 580
            |. .|:.....|| |:|.|.:|||||:|:||.|||||:.|.::.|||||.||||:|..::|.:.|
 Frog   511 IPYGLTCSPTQSNSSIQYACLQLIRSILREGCQLGQQTTCMQYLDKLNLVLRGNMSRTFELNNNE 575

Human   581 THELQSCLKQIIRNIKFKA--PPCNTFVDLTSACK----ISPASYNKEESEQMGKTSRKDMHCLE 639
            ..:||:||:|:|:.||.||  .|.:|....|:..:    |...|.:.::.:..|.:|       .
 Frog   576 VRDLQACLRQVIKIIKDKASTAPSSTLEQNTNRIESVPFIKSESVDDDDDDWYGASS-------S 633

Human   640 ASSPTFSKEPMKVQDSVLIKADNTIEGDNNEQNYIKDVKLEDHLLAGSCLKQSSKNIFTERAEDQ 704
            ...|:.:..|.:..|.|...|             :|....||        :.|...:.:.:....
 Frog   634 LEKPSSAVSPTECFDRVCWPA-------------VKKEPQED--------RPSEPELTSCKPSSS 677

Human   705 IKISTRKQKSVKEISSYTPKDCTSRNGPERGCDRGIIVSTRLLTDSSTDALEKVSTSNEDFSLKD 769
            |.:..:|:.||:  |..||...|                                          
 Frog   678 IAVEIKKESSVQ--SEPTPSALT------------------------------------------ 698

Human   770 DALAKTSKRKTKVQKDEICAKLSHVIKKQ--HRKSTLVDNTINLDENLTVSNIESFYSRKDTGVQ 832
               .:...||.|....|:.:|||.|:||.  .|:::|.:||..:||                   
 Frog   699 ---GEQQNRKPKTNLSELKSKLSKVLKKSSFKRQNSLPENTNRMDE------------------- 741

Human   833 KGDGFIHNLSLDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHE-----------NNC-- 884
                             |.|:...:|.|..||....:|:|.      |:           ::|  
 Frog   742 -----------------DKKSVAPESNNTFLPATTYIKSEP------HDPLFKQPSCNGNSSCSS 783

Human   885 -------KIQEFHVDGKELIPFTEMTNASEKKSSPFKDLMTVPESRDEEMSN---STSVIYSNLT 939
                   ::|...::.:  :|  |:...|.|.....:|...:.:::...:.:   |:|...|.:.
 Frog   784 DNVAVTKQLQRLSIENR--VP--EVQTVSVKNEPLLEDRKALSKNQISALKSFERSSSKPVSEVC 844

Human   940 REQAPD--------------ISPKSDTLTDSQIDRDLHKLSLLAQASVITFPSDS---PQNSSQL 987
            ...:||              :....:.|||||:||||..||:.|||..:.|.|..   .|:.|.:
 Frog   845 ESSSPDDDDNVPLFELRKKLLKKNKEQLTDSQVDRDLDSLSMAAQAKFLDFDSSQSVLSQDQSPI 909

Human   988 QRKVKEDKRCFTANQNNVG------DTSRGQVIIISDSDDDDDERILSLEKLTK-QDKICLEREH 1045
            |||||.     ||...|:.      |.|..|:|.|||..:|:.:..:|..|..| ..|:|     
 Frog   910 QRKVKG-----TARSPNIDSSSSETDVSLDQIITISDDSEDEKKPSISSVKSEKTSPKVC----- 964

Human  1046 PEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQCFEFESSSEVFSVWQDHPDDNNSVQDGEKKC 1110
            |....|..:.:..:..:|.|....| ..|:.|||.||||:..|||||||| ||     .|.::..
 Frog   965 PSTSTSEFSKRIAEAQIKPEPPPPL-TCEDYDSQFFEFETEDEVFSVWQD-PD-----VDQKEPV 1022

Human  1111 LAPI-------------ANTTN------GQGCTDYVSEVVKKGAEGIEEHTRPRSISVEEFCEIE 1156
            :||:             .|..|      |....|...:|::|.||..|......|..::      
 Frog  1023 IAPLHSEAAKPPISDPTGNDLNNEFDQWGYDTDDISDDVLEKAAEAAELSDSKPSKGLQ------ 1081

Human  1157 VKKPKRKRSEKPMAEDPVRPSSSVRNEGQSDTNKRDLVGNDFKSIDRRTSTPNSRIQRA----TT 1217
             ||||.|.||...:...|..||..|.:.......::..  :..:..::||:.:|::.|.    |.
 Frog  1082 -KKPKAKGSEGTFSVKGVSSSSFYRKDVPIAAKHKEKA--NIHTSPKKTSSLSSKVVRGKKTETV 1143

Human  1218 VSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQN-RSSNYLSCRTTPAIVPPKKFRQCPEPT 1281
            |:||..||        .|...:|:|.::     :|:| |..|.:  ||:||:|||||.|..|||:
 Frog  1144 VAQKIISK--------SKANRTKSPLRS-----RGENVRRENLI--RTSPAVVPPKKIRMAPEPS 1193

Human  1282 STAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVVDTRK-KTKLISPQNLSVRNNKKLLTS 1345
            |||||||.||.||||::|||||||.||:||:|||..|.|:.:| |.||||||:|.|:.|||:|..
 Frog  1194 STAEKLGFKKAPRKAFDLSQRSLDSVAELRNHGKMAGFVEPKKTKAKLISPQSLLVKCNKKMLAC 1258

Human  1346 QELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHTAQNSDIFVPESDRSDYNCTGGTEVLANSNR 1410
            |:||..||.||.....|::....|  |..|...:.|...|.....|.|.....|...|.::|..|
 Frog  1259 QDLQFYRQSRPNVPGKRKQAEALE--DGNRKIENAAHKIDKNGTSSSRHFQATTSHAEAISNKPR 1321

Human  1411 KQLIKCMPSEPETIKAKHGSPATDDACPLNQCDSVVLNGTVPTN-----------EVIVSTSEDP 1464
            .:....:.:|...|.....:.:|            ..||.:..|           |.:|::::|.
 Frog  1322 DERKLSISNEHLEISRTSSNKST------------AQNGEISLNSKLEKSSSHVLEKLVTSADDN 1374

Human  1465 LGGGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQNDPEDMDLCSQMENDNYKLIELIHGKDTV 1529
            .....||           .|.:|::..::.:|||||.||.||::|||:|.|             :
 Frog  1375 AFVLPPT-----------NEKESNNYEDDYDLFLTQADPVDMEMCSQVEYD-------------I 1415

Human  1530 EVEEDSVSR-----------PQLESLSGT------------KCKYKDCLETTKNQGEYCPKHSEV 1571
            :::|...||           |:|.:.|||            ||||.:|.|..|..|::||||...
 Frog  1416 DLDEGGASRVSDFSGSDAELPKLATGSGTELPKMGLNDGVPKCKYTNCTEMVKVAGDHCPKHMPP 1480

Human  1572 KAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAGLSKSLETSSALSPSLKNKSKGIQSILK 1636
            :.||:.:|.||||||..|||  .|||:|:|.:|||.|.|:|.||........||.|.:..::  .
 Frog  1481 EKADDHLFAKPGLPPSVSKP--STTKVFASSNTSRTASLTKDLENFPRPQGILKAKPQSAKA--P 1541

Human  1637 VPQ-PVPLIAQKPVGE-------MKNSCNVLHPQSPNNS--NRQGCKVPFGESKYFPSSSPVNIL 1691
            ||: |.||..|....:       :.|..||  |..|:.|  :..|...|:...|      |:   
 Frog  1542 VPKLPKPLTVQNRASDTNSVLQPLINQSNV--PSKPSYSAVSEAGKLRPYAAQK------PL--- 1595

Human  1692 LSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTF 1756
              .|......::|:|:||:|||.|..:.|||::|||.....||::|.:|.:|||||||||:||||
 Frog  1596 --QQRDQGWLMRELLQWKFEMFDNVSRFGPPSNLCQLPLLKVPIKFSSYEEYFNVFFPLMLLNTF 1658

Human  1757 ETVAQEWLNSPNRENFY----QLQVRKF-PADYIKYWEFAVYLEECELAKQLYPKENDLVFL--- 1813
            |::||||  |..::..:    :|.::.| |...:...||.|:..:.:|..|.:|||:|||||   
 Frog  1659 ESLAQEW--SVKQKAIHTDLCKLHLQNFCPDGLVNRGEFQVWFRDADLCMQRHPKEDDLVFLCMP 1721

Human  1814 --APERINEEKKDTERNDIQDLHEYHSGYVHKFRRT----SVMRNGKTECYLSIQTQENFPANLN 1872
              .|....||...      .....||:|||.:|.|:    |..:...|.|.|.|.||.|..|..|
 Frog  1722 ESTPSLSGEEMVS------HGARVYHTGYVSRFNRSHRTQSQEKEQYTLCDLCIHTQGNLSAFRN 1780

Human  1873 ELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNED 1937
            :.|.|.||.||:||||:.:|:..| .||.|.|.::.|||.||..:|...:.|....: |:::|.|
 Frog  1781 QQVRCAVIGSLITTQRQFRALLQL-QRNPLFRPIILPNPADFIPRDNAASESSSFPS-LKEYNSD 1843

Human  1938 QKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNR 2002
            |:.|||.||:|||..|.:.:||||||||||||||||||||||:|.||.......:|.:||.|:||
 Frog  1844 QRYAIEKAYSMVKQHPRLPRICLIHGPPGTGKSKTIVGLLYRILMENGSSTVPVQNLSAKNKRNR 1908

Human  2003 VLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNH 2067
            ||||||||||:|:|||||||||||||.:|..||||||||||||||.||:|:|:|:|||||.||||
 Frog  1909 VLVCAPSNAALDDLMKKIILEFKEKCHNKNTPLGNCGDINLVRLGAEKTISSDVVKFSLDCQVNH 1973

Human  2068 RMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKE 2132
            |:.:  ....|.:|||||.||.:||||||:|||.:..:. ....|||.|:::|||||.||..:|.
 Frog  1974 RITR--AQQDQELHKRKELLDRRLDELSRRRALEKCNKN-TCAPLDEEIARLSKERQLLADSLKL 2035

Human  2133 VQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIH 2197
            |:.|||:.|..||||||:||||||||||:|||||||..|..|||||||||||||||:|.|.||:|
 Frog  2036 VRRRPQELQRTIILESHVICCTLSTSGGILLESAFRQLGQEPFSCVIVDEAGQSCEVENLIPLLH 2100

Human  2198 RCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHP 2262
            ||:||:|||||:|||||||||||:|.||.||:|:|.|..|:...     ::.|:|.|||||||||
 Frog  2101 RCSKLVLVGDPEQLPPTVISMKAEELGYGQSLMSRMCSFLDSTG-----TKSPVLHLTVQYRMHP 2160

Human  2263 DICLFPSNYVYNRNLKTNRQTEAIRCSSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEII 2327
            |||||||:|.|.|.|||:|.||.:|||||||||||:||||.||.|:::.:|:.|.||||:.:.:|
 Frog  2161 DICLFPSHYFYKRMLKTDRATEEVRCSSDWPFQPYMVFDVADGFEQKERESFCNPQEIKVAVALI 2225

Human  2328 KLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEFDRK-GPAEVDTVDAFQGRQKDCVIVTCVR 2391
            ||||.::|:..|||||:||.|:|||..|.::|.:.|... .|.||||||.||||||||:||||||
 Frog  2226 KLIKSRKKEFCFRNIGVITPYRAQKMRIIEELRRAFGNDIRPGEVDTVDGFQGRQKDCIIVTCVR 2290

Human  2392 ANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMQLLPRSFCVHVNHSPFFSPEPKYLHWA 2456
            |||.||.||||||.|||||||||||:||||||.|||||                           
 Frog  2291 ANSTQGGIGFLASRQRLNVTITRAKFSLFILGSLRTLM--------------------------- 2328

Human  2457 LKENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQGGLPS 2521
              ||:.||.||||||:|||:|||.:::|:.|..||||||||:||:..||.: .||..:.....|.
 Frog  2329 --ENKDWNHLIQDAQRRGALIKTREEHYQRDVGKILKLKPVVQRAPIHPNS-RPEEKQKDSSAPP 2390

Human  2522 SKLDS------------------------GFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVH 2562
            .:::.                        .|.:.|.  :.::.||.|        :..|..|...
 Frog  2391 PRIEPPKETTQPPRKPLPAPSRPVIHPAVDFRRDSF--NTHNAPSGS--------AVGPLPPAPR 2445

Human  2563 DQLQDPRLLKRMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALS 2627
            .:||||||.:            |....:.     .:|||.......:....||   |::.||.  
 Frog  2446 SKLQDPRLAR------------WQETKTD-----TSPPTTLDSNARISTHSSH---PSSSVAG-- 2488

Human  2628 SHKPPVRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRT 2692
                   |..||                     ||::||.|:|.:    |.....|...|..|||
 Frog  2489 -------GSHPA---------------------RRDSRAVSDGSR----SSNSWNRDRDRRHKRT 2521

Human  2693 LEQEDSSSKKRKL 2705
            .|. |..||:|||
 Frog  2522 SEL-DKDSKRRKL 2533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETXNP_001338457.1 SEN1_N 37..>351 CDD:315409 219/315 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219 16/64 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604 15/24 (63%)
AAA_11 1933..2218 CDD:315699 191/284 (67%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 6/16 (38%)
AAA_12 2225..2424 CDD:315700 126/199 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706 22/80 (28%)
Necessary for nuclear localization 2690..2706 10/16 (63%)
setxXP_002936221.1 DEXXQc_SETX 1840..2157 CDD:350800 210/324 (65%)
AAA_12 2128..2323 CDD:404073 126/199 (63%)
PHA03247 <2365..2534 CDD:223021 54/235 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 740 1.000 Domainoid score I1467
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41003
Inparanoid 1 1.050 1940 1.000 Inparanoid score I736
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG39395
OrthoDB 1 1.010 - - D148890at33208
OrthoFinder 1 1.000 - - FOG0000219
OrthoInspector 1 1.000 - - oto159687
Panther 1 1.100 - - LDO PTHR10887
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4532
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.080

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