DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a9 and CG32669

DIOPT Version :9

Sequence 1:	NP_663526.3	Gene:	Slc5a9 / 230612	MGIID:	2140201	Length:	685	Species:	Mus musculus
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	137/576 - (23%)
Similarity:	244/576 - (42%)	Gaps:	85/576 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 SLGLHTYDIVVVVIYFVFVLAVGI-WSSIRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLF 89
            :||...|.|:.||:  :..:|:|| :..:...:.|...|.||.|||...|:..|||:|.:.:...
  Fly     3 TLGAWDYTILAVVL--IISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTI 65

Mouse    90 IGLAGTGAAGGLAVGGFEWNATFLLLALGWI---------FVPVYIAAGVVTMPQYLKKRFG-GQ 144
            :         |:::..:::...|:::.|.::         .:||:......::.:||:.||| ..
  Fly    66 L---------GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYAT 121

Mouse   145 RIQVYMSV-LSLILYIFTKISTDIFSGALFIQMALGWNLYLSTVILLVVTAVYTIAGGLTAVIYT 208
            |:...:|. |.::||    :...:::.||.::...|.:...|.||:.||...|...||:.||:.|
  Fly   122 RLAASLSFSLQMVLY----MGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLIT 182

Mouse   209 DALQTVIMVGGALVLMFLGFQEVGWYPGLQQLYRQAIPNTTVPNTTCHLPRPDAFHMLRDPVNGD 273
            |..|:::|......::...:.:.|   .|:.::|.|..|..: |.|.....|...|
  Fly   183 DIYQSLLMFAAVFSVIICAWVKAG---SLEVIWRVAQENGRI-NLTNFSVDPTERH--------- 234

Mouse   274 IPWPGLIFG--LTVLATWCWCTDQVIVQRSLAAKNLSHAKGGSVLGGYLKILPMFFI--VMPGMI 334
             .|...|.|  .|.||  .:..:|..|||.:|.|:||.|:  :.|...|.||.:..:  ...|:.
  Fly   235 -TWFTQILGGCATYLA--IYGVNQTQVQRLMAVKSLSAAR--AALWWCLPILCLLSLSTCFSGLC 294

Mouse   335 SRALYPDEVACVDPDICQRVCGARVGCSNIAYPKLVMALMP--VGLRGLMIAVIMAALMSSLTSI 397
            ....|.|         |..:...||...:...|..|:..|.  .||.||.::.|..|.:|:::||
  Fly   295 IYWYYRD---------CDPLLEGRVNSRDQVMPLFVVDTMGEYTGLAGLFVSGIFCASLSTISSI 350

Mouse   398 FNSSSTLFAIDVWQRF-----RRQASEQELMVVGRLFVVFLVVISILWIPIIQSSNSGQLFDYIQ 457
            .:|.:.:...|..:..     :|..::::.:...:|..:|...:.|..  ...:.:.|.|.....
  Fly   351 ISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFFGALCIGM--AFMAGSIGGLLQAAL 413

Mouse   458 SITSYLAPPITALFLLAIFCKRVNEPGAFWGLMFGLV----VGILR---MILEFSYSAPACGEMD 515
            ||...:..|:..||.|.::..:.||.||..||:..|.    :|..:   .::....|...| .:|
  Fly   414 SIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWIGFGQPKPPLVSLDMSTAGC-PVD 477

Mouse   516 RR----------PAVLKDFHYLYFALLLCGLTAIIIVVISFFTEPIPDDKLARLTW 561
            |.          .||.::.||.|...:.....|.:..:|:||...:.....|.|.|
  Fly   478 RSFARDIFLKTVIAVAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSWLFALLKW 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a9	NP_663526.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SLC5-6-like_sbd	45..685	CDD:382020	131/557 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..616
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	132/564 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6277
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840