DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMG1 and Tor

DIOPT Version :9

Sequence 1:XP_005255239.1 Gene:SMG1 / 23049 HGNCID:30045 Length:3689 Species:Homo sapiens
Sequence 2:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster


Alignment Length:2718 Identity:564/2718 - (20%)
Similarity:958/2718 - (35%) Gaps:843/2718 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    65 VVSRQRHDDTRVHADIQ------NDEKGGYSVNGGSG---------ENTYGRKSLGQEL-RVNNV 113
            :|:.|| :.|:..::.|      ::..|.::.:.||.         :..:|...:..|| |..|.
  Fly   205 IVTAQR-ESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANA 268

Human   114 T-SPEFTSVQHGSRALATKDM-RKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQL---K 173
            | ...:||:    :.|..|.. .|..|.|.|.|..|:|:.|:.|:        ::..:.:|   :
  Fly   269 TWERRYTSL----KTLFPKTQHNKFLEASSSSSMGSQLNTLVPRL--------KVPFIDKLGSTQ 321

Human   174 EFIQQPENKLVLVKQLDNILAAVHDVLNESSKLLQELRQE--GACCLGLL---CASLSYEAEKIF 233
            ..:.:.|:...:.|     .|:.|:||  .|...||:.||  .:.|..:|   .:...|..:.:.
  Fly   322 THLGEGEHHKGVAK-----FASQHNVL--ESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALL 379

Human   234 KWI--FSKFSSSAKDEVKLLYLCATYKALETVGEKK--------------AFSSVMQL----VMT 278
            :.:  .:.|:.:...| |.|..|.::......|::|              |..|.:::    :||
  Fly   380 QILPRLAAFNRAVFVE-KYLQTCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMT 443

Human   279 SLQSILENVD---------TPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPS 334
            |::..|.:.|         .|.:..    ||.|:|                        |..|..
  Fly   444 SVKVALPSKDLTSKRKVPVDPAVFA----CITLLA------------------------HAVKSE 480

Human   335 LTQQVSGWLQSLEPFWVADLAFSTTLLGQFLEDM----EAYAEDLSHVASGESVDEDVPPPSVSL 395
            :...|...|:.:  |:.......|..|.:..|::    .|..|.|..:.|...:::....|..:|
  Fly   481 IADDVKDILEQM--FYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTAL 543

Human   396 PKLAALLRVFSTVVRSIGERFSPIRGPPITEAYVT---------DVLYRVMRCVTAANQVFF--- 448
            |.:|    :..::::: |:      |.....|..|         ::|..|.||..     :|   
  Fly   544 PTIA----IDGSLMQN-GD------GATTVLALKTLGTFNFEEQNMLDFVQRCAD-----YFIVH 592

Human   449 --SEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIV--- 508
              .|..|.|...|..:|..::..|             :.:||.:|. :|.:..|:..|.::.   
  Fly   593 EQQEIRLEAVQTCTRLLKLAVQSS-------------ESMENSKTL-SDTVSHVIERLLMVAITD 643

Human   509 ------EQINTKLPSSFVEKLFIPSS-KLLFLRYHKE----KEVVAVAHAVYQAVLSLKNIPVLE 562
                  .:|...|..:|..||..|.| ..||:..|.|    :|:..|......::.....:|.|.
  Fly   644 MDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLR 708

Human   563 TAY-------------------------------KLILGEMTCALNNLLHSLQLPEACSEIKHEA 596
            |..                               :||...|...|..|:..|..||:        
  Fly   709 TTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPES-------- 765

Human   597 FKNHVFNVDNAKFVVIFDLSALTTIG-----NAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVH 656
                     |...:    |:.|.|||     |..:..:.:||  ..:.::|.:.|....|     
  Fly   766 ---------NPGVI----LNVLRTIGDLAEVNGGSDEMELWA--DDLLSILLEMLGDAGS----- 810

Human   657 FPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVIS-TVTTATKKH-FSIILNLLGILLK 719
             |..:...|:||                        |.:|| |....|..| :.:::::|...||
  Fly   811 -PDKRGVALWTL------------------------GQLISATGRVVTPYHKYPVLIDILINFLK 850

Human   720 KDNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLH 784
            .:......|:.:....|..|:             .|..||..|||:.:          |..:.|.
  Fly   851 TEQRRSIRRETIRVLGLLGAM-------------DPYKHKMNKGLIDS----------QKDNVLI 892

Human   785 ALSSSLPDDLLQRCVDVCRVQ-LVHSGTRIRQAFGKL----LKSIPLDVVLSNNNHTEIQEISLA 844
            |.|    |..:....|:...: ||:.|..:.:.:..:    |..|..|..||..:.:.:|.::..
  Fly   893 AYS----DGKVDESQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFI 953

Human   845 LRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRNLLKTD 909
            .:|...|....      .:.|:..:|  ::.||..:|..|.||         .|..|....:|..
  Fly   954 FQSLGIKCVPY------LAQVLPNLL--DNVRTADNNLREFLF---------QQLAILVAFVKLH 1001

Human   910 AVLWQWAIWEAAQFTVLSK---LRTPLGRAQDT-FQTIEGI-------IRSLAAHTLNPDQDVSQ 963
            .:.:...|     |.::.:   :.|||   |:| ...||.|       .|...|..:.....|.|
  Fly  1002 IISYMGDI-----FKLIKEFWTINTPL---QNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQ 1058

Human   964 WTTADNDEGHGNNQLRLVL--LLQYLENLEKLMYNAYEGCANALTSPPKVIRTFF--YT------ 1018
                     |.|::.|:|.  |||.|:.     :.:..|....|..|| :::.|.  |.      
  Fly  1059 ---------HDNSKDRMVTRRLLQALQK-----FGSTLGYYLPLILPP-IVKLFDSPYVPQQVSM 1108

Human  1019 ------NRQTCQ----DWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTI 1073
                  |...||    |:.:||...::||  |..:|        :|..:..||..|...:|    
  Fly  1109 VALETINNLACQLDFTDFSSRIIHPLVRV--LDAEP--------ELRDQAMTTLRSLAKQL---- 1159

Human  1074 MMVVEALCELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCC 1138
                                       ||..|....:.|:...:......||:|.|..:      
  Fly  1160 ---------------------------GKKYLVFVPMVQRTLNKHRIVDPEYEELLSKI------ 1191

Human  1139 ISSFDKSVLTLAN---AGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACECY-----I 1195
                 ||..|||:   ||.:...|....|.|...|    ..:|:.:.:....|:....:     :
  Fly  1192 -----KSCSTLADSYGAGESELRPSRFKNNEPFVT----DRNSNNKNLQVTTNELRTAWQVTRRV 1247

Human  1196 SIADWAAVQEWQNAIH-DLKKSTSSTSL----NLKADFNYIKSLSSFESGKFVEC-TEQLELLPG 1254
            |..||.   ||...:. .|.|.:.|.:|    :|..:::.:  |....:..|:.| ||       
  Fly  1248 SKDDWV---EWLKRLSIGLLKESPSHALRACRSLAQEYDTL--LRDLFNAAFISCWTE------- 1300

Human  1255 ENINLLAGGSKEKIDMKKLLPNMLSPD-PRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITE 1318
                                   |||| ..||.:|           |..||...:..:..|:|. 
  Fly  1301 -----------------------LSPDLKNELTQS-----------LIQALQVTDMPEITQTIL- 1330

Human  1319 NVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALR 1383
            |:.::::...|   .|:.:.|       .:|.|..:.|                           
  Fly  1331 NLAEFMEHCDR---DPIPIET-------KLLGTRAMAC--------------------------- 1358

Human  1384 SCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIR--SHLME-LGLTAAKFARKRGNVSLATRLL 1445
                   |.:.:||||           ||:...:|  |.:.| |.|...|..::.....|.||..
  Fly  1359 -------RAYAKALRY-----------KEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYR 1405

Human  1446 AQCSEVQL-GKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEMLSSCAI 1509
            ...:|:.: |:         .::||....:..|.:...|..:.:.|....|. ...:|.|...: 
  Fly  1406 NAANELNVQGR---------WYEKLHNWDEALEHYERNLKTDSSDLEARLGH-MRCLEALGDWS- 1459

Human  1510 SFCKSVKAEY----AVAKS----ILTLAKWIQAEWKEISGQLKQV---------YR---AQHQQN 1554
            ......|.|:    ..|||    :..:|.|...:|:.:...::.:         ||   |.|..:
  Fly  1460 ELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDD 1524

Human  1555 FTGLSTLSKNILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSW 1619
            |.....|......|::....:...|.|.|..........:.|.:.::  .|.|...:...:...|
  Fly  1525 FETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVI--QYKLIPERREPLKTMW 1587

Human  1620 AALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQA-VCRPAG- 1682
                     |.|      .|| |.||:...:..:|   ..::..:..|.|:..|..| :||.:| 
  Fly  1588 ---------WKR------LQG-GQRLVEDWRRIIQ---VHSLVVKPHEDIHTWLKYASLCRKSGS 1633

Human  1683 -------------------------IQDEDITLQITE--SEDNEEDDMVDVI------WRQLISS 1714
                                     .....:|...|:  :.:|:..:..:.:      :.|.:|.
  Fly  1634 LHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSC 1698

Human  1715 CP---------------------WLSELDES----ATEGVIKVWRKVVDRIFSLYKL-SCSAYFT 1753
            .|                     |.::|.:|    |.:|.::.:.|......:.||. ...||..
  Fly  1699 LPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWAYMN 1763

Human  1754 FLKLNAGQIPLDEDDP---RLHLSHRVEQSTDDMIVMA-----------------------TLRL 1792
            |..:.|.:..||:..|   .:.::......:|.||:..                       ||||
  Fly  1764 FKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNSLQDTLRL 1828

Human  1793 LRLLV---KHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPH 1854
            |.|..   .|| |:.:.|..|::......|..:||||.:|::.....|.|.|..||..:.::.|.
  Fly  1829 LTLWFDYGNHA-EVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKNHPQ 1892

Human  1855 LILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGL 1919
            .::||.   |::..|.|.|..|                                           
  Fly  1893 ALVYPL---TVASKSASLARRN------------------------------------------- 1911

Human  1920 NEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQL 1984
                     ...||:|.:...:||:|.|..|...||.||.:||.|.|       |       :.|
  Fly  1912 ---------AAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQW-------H-------EGL 1953

Human  1985 EDEVKRVQNNNTLRKE----EKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYG 2045
            |:..:....:..::..    |.:..|.|:....:|...|:..:.|.:|.|      .:|.|....
  Fly  1954 EEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEA------YEWSQRYKT 2012

Human  2046 DAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTNTEIALP 2110
            .|:...|::            :|..:..:...:.::..:..|  |.|..:||.|....:.|:|:|
  Fly  2013 SAVVMDLDR------------AWDIYYHVFQKISRQLPQLTS--LELPYVSPKLMTCKDLELAVP 2063

Human  2111 GEVS-ARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN 2174
            |..: .::.:.|..:...:.::.:|.:|:||...||:||.|.||.||.|||..|||:||..|:||
  Fly  2064 GSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVN 2128

Human  2175 TMFATINRQETPR--FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSY 2237
            |:.  ::..:|.|  ...:.|:|.||.|.||||.||.....|..|.:.::.::.....|:    :
  Fly  2129 TLL--LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQE----H 2187

Human  2238 QTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWS 2302
            :|..|              ..|....:.|...|.           |.|..:..|..:.|||.||.
  Fly  2188 RTMLN--------------FAPDYDHLTLMQKVE-----------VFEHALGQTQGDDLAKLLWL 2227

Human  2303 SCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGNIKVD 2367
            ...:.:.|:....:|.||.|||||||||:||||||..|:::|..:|:::|||:..|||....:..
  Fly  2228 KSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREK 2292

Human  2368 FTFMRAKCFLVKGQKYNDLSFQGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMR 2432
            |                           |||:|||:|:.:..|:.|||:||.:|.:||.|:.::|
  Fly  2293 F---------------------------PEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLR 2330

Human  2433 RGRETLLTLLEAFVYDPLVDW------TAGGEA-GFAGAVYGGGGQQAESKQS 2478
            |.:::|:.:|||||||||::|      ..|.:| ..|||..|.||...:...|
  Fly  2331 RNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLS 2383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMG1XP_005255239.1 SMG1 631..1242 CDD:292413 130/661 (20%)
PIKKc_SMG1 2121..2454 CDD:270714 114/340 (34%)
FATC 3659..3688 CDD:280430
TorNP_001260427.1 TEL1 308..2471 CDD:227365 538/2610 (21%)
HEAT repeat 632..658 CDD:293787 4/25 (16%)
HEAT repeat 668..698 CDD:293787 7/29 (24%)
HEAT repeat 706..736 CDD:293787 2/29 (7%)
HEAT repeat 749..780 CDD:293787 12/51 (24%)
HEAT repeat 798..823 CDD:293787 7/54 (13%)
DUF3385 831..999 CDD:288698 41/211 (19%)
HEAT repeat 841..870 CDD:293787 5/28 (18%)
HEAT repeat 880..917 CDD:293787 12/50 (24%)
HEAT repeat 925..954 CDD:293787 6/28 (21%)
Rapamycin_bind 1937..2034 CDD:285924 24/128 (19%)
PIKKc_TOR 2075..2353 CDD:270713 114/335 (34%)
FATC 2440..2471 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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