DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMG1 and nonC

DIOPT Version :9

Sequence 1:	XP_005255239.1	Gene:	SMG1 / 23049	HGNCID:	30045	Length:	3689	Species:	Homo sapiens
Sequence 2:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	3937	Identity:	997/3937 - (25%)
Similarity:	1569/3937 - (39%)	Gaps:	1028/3937 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    58 LQPSNSAVVSRQRHDDTRVHADI-----QNDEKGGYSVNGGSGENTYGR---------KSLGQEL 108
            :.|.|......:....:..||:|     .|:...|.|.|.|.|.|..||         ..||..
  Fly     5 IHPENCNGAGTEEEASSAFHAEIDRVLLNNNGNHGDSSNEGGGGNGSGRGGATGSGNIAGLGGS- 68

Human   109 RVNNVTSP----EFTSVQHGSRALATKDM--------------RKSQE------RSMSYSDESRL 149
              .::.||    .....|..:.||..::|              ||:.:      ..|:..::.||
  Fly    69 --ESMWSPGGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCKGDTINPMANGEDLRL 131

Human   150 SNLLRRITREDDRDRRLATVKQLKEFIQQPEN----KLVLVKQLDNILAAVHD----VLNESSKL 206
            |.::||:..|::....|....:|.:.::.|.|    ....|..|||:|.....    ||.|.||
  Fly   132 SKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSK- 195

Human   207 LQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSAKDEVKLLYLCATYKALETVGEKKAFSS 271
                      .|||: ..::.::..|::....|...|:|...|  |:....:|..:...|.....
  Fly   196 ----------TLGLI-GFINRKSYPIYEEFIVKNYKSSKRMQK--YMIMALRATLSCDTKCELHM 247

Human   272 VMQLVMTSLQSILENVDTPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLT 336
            ....:|..|:..|||.::.::.......::..|..|...|..:|.|.|||::||.::..|...|.
  Fly   248 YADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLK 312

Human   337 QQVSGWLQSLEPFWVADLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAAL 401
            ...:..|:.|.||:...:.||..||.||:||:....|       ||        |:.:..::.|.
  Fly   313 THCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEE-------GE--------PANTAERVGAF 362

Human   402 LRVFSTVVRSIGERFSPIRGPPITEAYV---TDVLYRVMRCVTAANQVFFSEAVLTAANECVGVL 463
            :..|:|:::.:. |.....|.|..|..|   .|.|.::|      ..:..:...|...||.:.:.
  Fly   363 VGAFNTLLKCLA-RMQIFVGMPTCECIVKMAVDHLIKIM------PTLHLNTEALVNINELICIC 420

Human   464 L----GSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLF 524
            |    ..|||   |..:.|:   |||::...:.......|||.||...|.::..:|..|.|..:|
  Fly   421 LLNNFTGLDP---ILLEQVL---LDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIF 479

Human   525 IPSSKLLFLRYHKEKEV-VAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEA 588
            ..:..:..:|.....|. ..:.....|..|.::|:|:|:.|||.::.::...|..||  :..|.:
  Fly   480 QSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLL--ITAPRS 542

Human   589 CSEIKHEAFKNHVFNVDNAKFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDL 653
                          ....|..:::|.||||..:....:|:|||:|..|::..||..|........
  Fly   543 --------------KARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKF 593

Human   654 AVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLL-GIL 717
            ...:||.|.|:...|..||..:.:|     .::|..|.|..:.:..|:.|...|:.||..| .:|
  Fly   594 WSKYPAAQQAIFGLLVVHCQANHNF-----RTNSSLLRDQELSAENTSPTANSFASILRFLDSVL 653

Human   718 LKKDNLNQDTRKLLMTWALEAAVLMKKSETYAPLFSLPSFHKFCKGL--LANTLVE-DVNICLQA 779
            .:...|.....::|:.|.  ..:|.:..|....|....:|...|:.:  .|:.||. :...|:|
  Fly   654 GQAHQLAPQNLRVLLQWI--QMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQ- 715

Human   780 CSSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQ----------AFGKLLKSIPLDVVLSNNN 834
                     ::.|..|:|.....::.:::..|.::|          .:.::...:||.:.|:..
  Fly   716 ---------TVLDYGLERLEKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGG- 770

Human   835 HTEIQEISLALR---------SHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFY-S 889
              |.....:|.|         |..|....|.|  :||.|.:.     ...:....:.|..||. |
  Fly   771 --ESSMPGMASRRVSVWQQRISQYSAVRDNVF--RDFFDRVQ-----KPEQDSLIHCLRELFVRS 826

Human   890 CQ--RLDKRDQSTIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAA 952
            ||  ..|:| |..:.:...:...:...|..:|||::.|..:|||.:|:.|:||...|.||...|.
  Fly   827 CQVAPQDER-QMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHAR 890

Human   953 HTLNPDQDVSQWTTAD-NDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFF 1016
            ......:::.:....| :.|...:.|..|.|||.:|:.||||:|||.||.|.||..|.|.:..||
  Fly   891 LLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFF 955

Human  1017 YTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKT--TSLSQGNELEVTIMMVVEA 1079
            ..|..|||.|..|||:.::.:.:...||.:.:|:...:|...||  .:.||.        :|..|
  Fly   956 RLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQA--------IVYMA 1012

Human  1080 LCELHCPEA--IQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSF 1142
            ...:.|.||  ::|:.:|:.....|:..|:...|.||.|:.|.|...|
  Fly  1013 WSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGY----------------- 1060

Human  1143 DKSVLTLANAGRNSASPKHSLNGESRKTVLSK---PTDSSPEVINYLGNKACECYISIADWAAV- 1203
                                      :|:|::   .::..|....::.::..:|...:..|:.:
  Fly  1061 --------------------------RTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLV 1099

Human  1204 ---QEWQNAIHD------LKKSTSSTS----LNLKADFNYIKSLSSFES--GKFVECTEQLELLP 1253
               |:......|      |::|....:    |..|::    :|.||.::  |.|    :||.|.|
  Fly  1100 ELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSE----ESCSSMDALGGVF----QQLSLWP 1156

Human  1254 G---ENINLLAGGSKEK--------------IDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLA 1301
            .   |:::  :.|..|:              |.:.|||.:...||  :.:..::.| .|.|:
  Fly  1157 SNWDESVS--SSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPD--QAKNLLDTQ-WRDSL--- 1213

Human  1302 TALNPIEQDQKWQSITENVVKYLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSN 1366
              |||....:..:.:|  :::::.|.   ..|...||.|.||                     |.
  Fly  1214 --LNPSFDQRSCKELT--LLRHIVQG---VSGGQELSLLPVS---------------------SG 1250

Human  1367 RLSTEDCLIPLFSEALRSCKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKF 1431
            |.......|.  |..|..|     ..|.|.||             :...|  .....|.|.||..
  Fly  1251 RCQNRSKFIS--SAILMRC-----LAWTQLLR-------------QHCAP--GSWETLCLDAAAA 1293

Human  1432 ARKRGNVSLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPEL-----DIEKTKLL 1491
            ||:.||:.||..||.|.....:|:......|.|..       |.|   .||:     ::.|...|
  Fly  1294 AREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGV-------QTD---NPEMLRGYSELVKCLHL 1348

Human  1492 YTAGQSTHAMEMLSS---CA---ISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQ 1550
            ......||:.::.||   ||   ::..||.....|.|..:|.||.||..
  Fly  1349 QQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAV---------------- 1397

Human  1551 HQQNFTGLSTLSKNIL--TLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAP 1613
              :...||:|....:|  .|.:||       |.| :..:|:..:.:.:.:.::.:|.|....|.|
  Fly  1398 --RTCNGLTTNQSPVLIQLLDQLP-------ECP-LTCDSSQPLAIPQAERMVARLVHSCLQQRP 1452

Human  1614 EVAKSWAALASWAYRWGRKVVDNA---SQGEGVRL-------LPREKSEVQNLLPDTITEEEKER 1668
            ..|::..|..:|.||||:||.|:.   :|.:...:       .|.|..::..||....||:....
  Fly  1453 NYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPAN 1517

Human  1669 IYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVW 1733
            ..     .||..|....:|      |:..|.            :....:|::....|.:.::::|
  Fly  1518 CV-----EVCPDAARARDD------EAAKNR------------LRRLTFLADKTPEALDAILQIW 1559

Human  1734 RKVVDRIFSLYKLSCSAYFTFLKLNAGQIPLDEDDP----------RLHLSHRVEQSTDDMIVMA 1788
            |:.:...:..||.:..:||.:|...:|..|   :.|          |||:.       |..:|..
  Fly  1560 RRAIANTYDYYKDAARSYFQYLSFKSGSGP---EKPEGEGVVSQRERLHVD-------DSNLVTT 1614

Human  1789 TLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSP 1853
            |||||||:||||..|::.||.||.|||.|||:.|||||||||||.|.|||:|:|:||||:|:..|
  Fly  1615 TLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRP 1679

Human  1854 HLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSG 1918
            .|:::||:||.   :.|.|.:....:||.||
  Fly  1680 QLVIFPAVVGA---NREQQDATAPPATARPT---------------------------------- 1707

Human  1919 LNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQ 1983
             .||..    ||..::.:||...|..|..|:::|.|||||.:||||.|:..|...:...:.|:..
  Fly  1708 -TEDAC----CYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSA 1767

Human  1984 LEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNYGDAI 2048
            |..:.:...:..   |..:..:.|.:       ::..||.:.::|:.|.||.:|:.|:..:...|
  Fly  1768 LATDFRPDDHEG---KNNRFNVWRPQ-------LLADLEALVAVTSRPPETTYERSFRKRFDAPI 1822

Human  2049 ENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTNTEIALPGEV 2113
            ...::.|:....|    .:|...|::...||....:.:...|:::.|||.|..:....|::|| :
  Fly  1823 RLTVDALRHRRYP----EAWDKLKQLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPG-L 1882

Human  2114 SAR----DTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN 2174
            .|.    |.|.|.||..::.:|||||||||:.|.||:|:.|.:||||:|||||||||||||||.|
  Fly  1883 DAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISN 1947

Human  2175 TMFATINRQETPR---FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDS 2236
            .:.|.  |.:.|.   :.|.||||.|||.:||||.||||.||:|.|||:||||.:
  Fly  1948 AIMAC--RSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRS---------- 2000

Human  2237 YQTPQNPGI-----VPRP-SELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNL 2295
             |...|.|.     |||. ::|:|:|:.|.|....:.:...||.||:.|:..||:||.:.||.:|
  Fly  2001 -QVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDL 2064

Human  2296 LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFE 2360
            ||:|||.......||.:..:.:.|..:||||:||:|||||||||||||::.:|::||||||||||
  Fly  2065 LARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFE 2129

Human  2361 KGNIKVDFTFMRAKCFLVKGQKYNDLSFQGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCE 2425
            |                            |::||:|||||||:|||:..|:|:||:||.|||.||
  Fly  2130 K----------------------------GRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCE 2166

Human  2426 QVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEA-----------------GFAGAVYGGGGQQA 2473
            .||.:||:.||||||||||||||||||||...:|                 |.||.:  |.|...
  Fly  2167 YVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGL--GVGDLK 2229

Human  2474 ESKQSK---REMEREITRSLFSSRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQ----EQLT 2531
            ..|:.|   :.::.::.|..|.|::..::..|..|:.|:   :|:|:....|..:||    :|:.
  Fly  2230 YHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTEL---MPQLEEMEQEVGNLQAAQAKQVV 2291

Human  2532 DVEKL-----QGKLLEEIEFLEGAEGVDHPSHTLQHR------YSEHTQLQTQQRAVQ-EAIQVK 2584
            ..|:|     :..|:.||:.| |.....|..:|...|      :||...|.:.:|... ..:|..
  Fly  2292 AEEELVKLNQRSALIAEIKSL-GTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCI 2355

Human  2585 LNEFEQWITHYQAAFNNLEATQLASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEG 2649
            |..:.|.:..|...  :|:. ||..|..|.:::   ....:...|..||.:|...:.||..:|.|
  Fly  2356 LRSYGQCLQLYHLL--DLQG-QLVKLQMESNSE---NAREFSALTEALQLSGLDSMRSQLNELLG 2414

Human  2650 EVGALLQQRRSVLRGCLEQLHHYATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRK 2714
            .:..:.|:..       :.|..||.|...||:   |.||                    |.|:.:
  Fly  2415 RMDMVAQKSS-------KHLQEYAGVMNFYPE---QSHR--------------------QNLFVR 2449

Human  2715 YEMQYAPQPPPTVCQFITATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKV 2779
            :...:|     |..|         ..|.||..:........:..:|..|.|.|......|| :..
  Fly  2450 FHDSFA-----TYIQ---------NGYTADSTTNTNSPSSSIICKADVVGVAEAMEYSWER-LGC 2499

Human  2780 FLHENGEEGSLSLASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVT 2844
            .|||             .|.|....:...:..||.::|   |:.:..:.|       ||
  Fly  2500 QLHE-------------ASKLYAANQAQALTLGAPTTA---LLSMIVQSG-------CS------ 2535

Human  2845 CLVQLLKQCHLVPQDLDIPNPMEASETVHLANGVYTSLQE--LNSN-----FRQIIFPEALRCLM 2902
               |||.:..||             .|:..|.|.:.:.::  |.|:     ..|::|...:|.::
  Fly  2536 ---QLLLKASLV-------------RTLDRAGGAFAAYEQVALASHDDGLLHHQLLFIHLVRTML 2584

Human  2903 KGEYTLESMLHELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGE 2967
            :|...   |..|.|..:.|          :|||.:.|.:.....|.:..|   ::.|||
  Fly  2585 QGVLV---MTKEEDQHLAQ----------LESLLSALSHLKKMFEYDLPA---NLYRLL------ 2627

Human  2968 LIQPRNGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQ 3032
            |:||..|.:.....:||..:         ||      |.:|                     :|.
  Fly  2628 LLQPNLGKLSALCHLSASSL---------AQ------LFLE---------------------ATM 2656

Human  3033 VNFFDDDNHR---QVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGS--SSLEDQNTVNGPVQIVNV 3092
            .|     .|:   |...|..||..||.:.:.|.|..|...:|..|  |.|||.:.|. ..||:.:
  Fly  2657 EN-----GHKPPDQFPVERRFLLTLQPVYDQFLLASTSLDSLVSSMQSMLEDVHDVQ-TQQIMEL 2715

Human  3093 ------KTLFRNSCF----SE----------DQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSF 3137
                  .|...:.||    ||          .:||:|:..|......:.|.||    |.:...:|
  Fly  2716 GLMRSCHTELNDECFFGLVSEALESSRTCDVREMARPMLGFIHRLQVEKLAGL----LPILTRNF 2776

Human  3138 ISALGVDIIAQVEAKDFGAESKVSVDDLCKK----------AVEHNIQIGKFSQLVMNRATVLAS 3192
            .:|:|...:......|     ....|.||:.          .::...:|...||.| :..|:.||
  Fly  2777 YTAVGPQCLPTASCGD-----PAQADHLCESLFISLQSDGALLQQQAEIALLSQQV-DLHTLAAS 2835

Human  3193 SYDTAWKK----------HDLVR-RLETSISSC-------KTSLQRV---------QLHIAMFQW 3230
            :...|:.:          |.:.| :|..:|..|       .|:||::         ||......|
  Fly  2836 AQYWAYSEALGSQLRCGPHIVSRPKLTAAIGECWLELDQKLTALQQLQAGLESQLSQLQTQRSNW 2900

Human  3231 --QHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIATVQEKLAALESSIEQRL---- 3289
              .|.|.|:...|..........|:|..|......::::|.:...|.|:..||...:||.|
  Fly  2901 NRNHIDNLLRMEQCNKQRTMSHVALLQKMTDGAGAVARLEQNAIVVGEEGQALVDHLEQWLAAHG 2965

Human  3290 KWAGGANPALAPVLQDF-----------------------EATIAERRNLVLKESQRASQVTFLC 3331
            :|...:: .::.|.|..                       |.|....|.:...|.::.|:..|:|
  Fly  2966 QWQASSS-RISAVEQSMVELLDPEGAIDHYWLENVQGLLEEQTCKVHREIAAIEGEQQSKHRFIC 3029

Human  3332 SNIIHFESLRTRTAEALNLDAALFELIKR--CQQMCSFASQFNSSVSELELRLLQRVDTGLEHPI 3394
            :  :..|:||            |.|.:.|  .|.:||.|..  ....::|...:|.:...|....
  Fly  3030 T--LLKETLR------------LLENMPRFHVQSLCSEAQA--QGQGKMEYANVQLLSDHLREGQ 3078

Human  3395 GSSEWLLSAHKQLTQDM-STQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGDVKHLLK 3458
            |..:.|....::|.:|: |.:|.:|.          ..:||....::.:||
  Fly  3079 GLMQSLYMRLQELRKDICSDRRVLQP----------SMLQNWRHQLEMILT-------------- 3119

Human  3459 AMAKDEEAALADG-EDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQEHVEMLQEITP 3522
             :||.|......| ||      ..|..||..|::      :||..:..|.|..
  Fly  3120 -LAKQEVNEFFKGLED------FMQHAGETDSYE------IFTHAKGSGNVHE------------ 3159

Human  3523 TLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRSNTGQKTQPDVMSQNA 3587

  Fly  3160 ----------------------------------------------------------------- 3159

Human  3588 RKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQERNSYAVSVWKRVKAKLEGRD 3652
                                                       |:||:|.|||||:::.||||||
  Fly  3160 -------------------------------------------QKRNAYGVSVWKKIRMKLEGRD 3181

Human  3653 VDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3689
            .|.|:|.:|||||||||:||.|.:|||.||||||.||
  Fly  3182 PDSNQRSTVAEQVDYVIREACNPENLAVLYEGWTPWV 3218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMG1	XP_005255239.1	SMG1	631..1242	CDD:292413	151/660 (23%)
		PIKKc_SMG1	2121..2454	CDD:270714	174/341 (51%)
		FATC	3659..3688	CDD:280430	21/28 (75%)
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	148/651 (23%)
		Rapamycin_bind	1738..1845	CDD:285924	28/120 (23%)
		PIKKc_SMG1	1894..2196	CDD:270714	175/342 (51%)
		FATC	3189..3217	CDD:280430	21/27 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159038
Domainoid	1	1.000	321	1.000	Domainoid score	I1235
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	899	1.000	Inparanoid score	I384
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45627
OrthoDB	1	1.010	-	-		D12810at33208
OrthoFinder	1	1.000	-	-		FOG0007362
OrthoInspector	1	1.000	-	-		oto89107
orthoMCL	1	0.900	-	-		OOG6_104562
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2799
SonicParanoid	1	1.000	-	-		X6240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.700